2046: Using a Novel Combination of Drugs to Treat Arrhythmia and Heart Failure in Dogs

Grant Status: Open

Grant Amount: $33,060
Janice McIntosh Bright, DVM, BSN; Colorado State University
January 1, 2014 - June 30, 2018
Sponsor(s): American Cavalier King Charles Spaniel Club Charitable Trust, Chihuahua Club of America, Saluki Health Research, Inc., Staffordshire Terrier Club of America
Breed(s): -All Dogs
Research Program Area: Cardiology


Atrial fibrillation is a common heart rhythm abnormality (arrhythmia) in dogs. This arrhythmia affects all dog breeds and frequently coexists with heart failure causing worsening of disease and high mortality. Atrial fibrillation may be managed by administering drugs to slow heart rate or by restoring normal rhythm (cardioversion). Dr. Bright will evaluate dogs with naturally occurring atrial fibrillation and heart failure for their responsiveness to two drugs -- amidodarone, an antiarrhythmic agent, and ranolazine, a drug used in humans with coronary heart disease. She will determine whether ranolazine given with amiodarone prolongs normal rhythm compared to amiodarone alone and whether ranolazine also improves heart function. Results will validate combined ranolazine/amiodarone administration as an improved new treatment for atrial fibrillation in dogs with heart failure, extending their quality of life.


None at this time.

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