02631: Genetic and Metabolic Determinants of Dilated Cardiomyopathy and their Relationship to Cardiac Arrhythmia in Doberman Pinschers

Grant Status: Open

Grant Amount: $77,760
Hannes T. Lohi, PhD; The Folkhälsan Institute of Genetics
May 1, 2019 - April 30, 2020
Sponsor(s): Orthopedic Foundation for Animals
Breed(s): Doberman Pinscher
Research Program Area: Cardiology

Abstract

Dilated cardiomyopathy (DCM) is a common inherited disease in Doberman Pinschers that can lead to heart failure. The genetic background is not known and an international research project has been established to discover genetic risk variants that predispose dogs to DCM, and to study how cardiac arrhythmias are connected to DCM. Nearly 600 dogs will be studied with cardiological examinations to determine the health and function of the dog’s heart using electrocardiogram, echocardiography and Holter monitoring. Genetic studies have identified a novel disease locus in chromosome 5 and the investigators will perform the additional analyses to identify the causative gene and variant(s).  If successful, the genetic findings in this study will have a broad impact on the health of Doberman Pinschers and potentially other dog breeds.

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