02631: Genetic and Metabolic Determinants of Dilated Cardiomyopathy and their Relationship to Cardiac Arrhythmia in Doberman Pinschers
Grant Status: Open
Dilated cardiomyopathy (DCM) is a common inherited disease in Doberman Pinschers that can lead to heart failure. The genetic background is not known and an international research project has been established to discover genetic risk variants that predispose dogs to DCM, and to study how cardiac arrhythmias are connected to DCM. Nearly 600 dogs will be studied with cardiological examinations to determine the health and function of the dog’s heart using electrocardiogram, echocardiography and Holter monitoring. Genetic studies have identified a novel disease locus in chromosome 5 and the investigators will perform the additional analyses to identify the causative gene and variant(s). If successful, the genetic findings in this study will have a broad impact on the health of Doberman Pinschers and potentially other dog breeds.
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Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.