1982: Personalized Medicine: The Intersection of Genotype and Drug Responsiveness in the Treatment of Canine Pulmonary Hypertension

Grant Status: Open

Grant Amount: $27,971
Dr. Joshua A Stern, DVM, University of California, Davis
January 1, 2014 - December 31, 2016
Sponsor(s): American Bullmastiff Association
Breed(s): -All Dogs
Research Program Area: Cardiology

Abstract

Genetic background is thought to alter the way animals and humans respond to disease and drug therapy. The unique DNA signature of an individual is now recognized as a pivotal influence on disease outcome during treatment and has become the central concept propelling the study of pharmacogenomics and individualized medicine. Dr. Stern will apply this cutting-edge knowledge to pulmonary hypertension in dogs, a common disease with serious consequences including exercise intolerance, respiratory distress, and sudden death. Dr. Stern has identified a mutation in the gene phosphodiesterase 5A (PDE5A), the target of a drug called sildenafil, and believes this mutation may influence responsiveness of dogs to the drug. Dr. Stern will evaluate the responsiveness of dogs to sildenafil through pre- and post- echocardiogram, identification of biological markers of disease, and quality of life questionnaires. Differences between treatment responses will be compared to genotype. He aims to establish a diagnostic test that allows clinicians to make treatment recommendations on a personalized basis and tailor the therapeutic approach to treatment of pulmonary hypertension.

Publication(s)

Visser, L. C., Im, M. K., Johnson, L. R., & Stern, J. A. (2016). Diagnostic Value of Right Pulmonary Artery Distensibility Index in Dogs with Pulmonary Hypertension: Comparison with Doppler Echocardiographic Estimates of Pulmonary Arterial Pressure. Journal of Veterinary Internal Medicine, n/a–n/a.

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