2531: Identification of Genetic Risk Allele(s) Associated with the Development of Tricuspid Valve Dysplasia in the Labrador Retriever
Grant Status: Open
Tricuspid valve dysplasia is an inherited heart defect that is characterized by an abnormally formed tricuspid valve on the right side of the heart. It is reported to be most commonly observed in the Labrador Retriever although it has been observed in a few other breeds as well including the Boxer and Golden Retriever, among others. Although some affected dogs only have a very mild valve malformation and can live quite comfortably with the defect, others are born with a very abnormal valve that results in heart valve leakage and the eventual development of congestive heart failure. Tricuspid valve dysplasia has been shown to be an inheritable trait in the Labrador Retriever. The investigators will study and compare the genome sequences for affected and unaffected dogs. If successful, this study will identify a genetic marker for tricuspid valve dysplasia in the Labrador Retriever and which can be used to develop a strategy to gradually reduce the prevalence of the genetic variant and tricuspid valve dysplasia in the Labrador Retriever.
This research is generously supported by the Labrador Retriever Club of the Potomac Top Twenty Gala Foundation and the Labrador Retriever Club, Inc.
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