00572-A: Heritability of Atopic Dermatitis in West Highland White Terriers

Grant Status: Closed

Grant Amount: $12,916
Dr. Thierry Olivry, DVM PhD, North Carolina State University
April 1, 2005 - March 31, 2006
Breed(s): West Highland White Terrier
Research Program Area: Prevention

Abstract

In dogs, atopic dermatitis (AD) is a very common chronic allergic skin disease that results in severe itching and skin lesions following self-trauma, impairing the quality of life of affected dogs. Atopic dermatitis has a high frequency of occurrence in several dog breeds, and it is especially common in West Highland White Terriers. We intend to collect clinical data, pedigree information and blood samples from Westies affected with AD and from their normal family members to determine the mode of transmission of this disease. Genomic DNA will be extracted from blood samples and stored. In the future, we intend to link the AD trait to a specific chromosomal region of the canine genome. Examination of corresponding regions in human and mouse genomes will result in identification of likely candidate genes. Later studies will evaluate the linkage of AD with candidate genes, with the purpose of identifying the mutation underlying AD in this breed. Results of these studies should permit the identification of puppies carrying the disease before lesions occur, thus allowing elimination of this trait in Westies.

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