1577: Identifying the Genes Conferring Risk for Transitional Cell Carcinoma

Grant Status: Open

Grant Amount: $45,000
Dr. Elaine A Ostrander, PhD, National Human Genome Research Institute
January 1, 2012 - June 30, 2014
Sponsor(s): German Shepherd Dog Club of America, Norwegian Elkhound Association of America, Inc., Siberian Husky Club of America
Breed(s): Shetland Sheepdog, West Highland White Terrier, Scottish Terrier
Research Program Area: Oncology

Abstract

Cancer is a major cause of death in older dogs and treatment is often ineffective. Genetic (heritable) factors are important in development of Transitional cell carcinoma (TCC) of the bladder. The Scottish and West Highland White terriers and the Shetland sheepdog are at high risk for TCC, and a subset of dogs of each breed are born with errors in critical genes that predispose them to the disease. Using these breeds as models for genetic risk, Dr. Ostrander will narrow in on two regions of the genome where error-prone genes were discovered and identify the mutation as well as fine map the remaining critical gene. Methods developed in this effort will translate to other cancers and thus have the potential to help dogs of many breeds.

Publication(s)

- Both ends of the leash: the human link to good dogs with bad genes (2012) Ostrander EA. New England Journal of Medicine, 367(7):636-46. - Subcutaneous 5-azacitidine treatment of naturally occurring canine urothelial carcinoma: A novel epigenetic appr

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