02681-A: Analysis of Canine Herpesvirus Isolates Using Next-Generation Sequencing
Grant Status: Closed
Abstract
Canine herpesvirus (CHV-1) is a common and serious disease of puppies and adult dogs. It is often fatal in puppies and can cause serious illness such as ocular disease, upper respiratory disease and vaginitis in adult dogs. This study will use cutting edge technology to determine the DNA sequence of canine herpesvirus isolates collected from dogs in the U.S. Sequenced DNA will be analyzed to study the virus at a genomic level and to highlight differences in viral genomes based on geographic location. This level of characterization will represent the largest work for CHV-1 worldwide to help prevent disease and inform novel therapeutic targets for treatment.
Publication(s)
Lewin, A. C., Coghill, L. M., Mironovich, M., Liu, C.-C., Carter, R. T., & Ledbetter, E. C. (2020). Phylogenomic Analysis of Global Isolates of Canid Alphaherpesvirus 1. Viruses, 12(12), 1421. https://doi.org/10.3390/v12121421
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.