02782: Genetic Contribution to Early-onset Osteosarcoma
Grant Status: Open
Abstract
Osteosarcoma is a devastating disease that affects many dog breeds. Although osteosarcoma is typically a disease of older dogs, in some breeds, such as the Irish Wolfhound, dogs can be affected at a young age. This study will investigate the genetic basis of early-onset osteosarcoma in the Irish Wolfhound breed. Osteosarcoma is responsible for ~20% of deaths in the Irish Wolfhound breed, with many dogs being diagnosed before 5 years of age. Consequently, there is a critical need to advance understanding of the genetic basis of early-onset osteosarcoma in the Irish Wolfhound. State-of-the-art DNA sequencing will provide insight into an osteosarcoma-associated genetic variant that strongly influences disease risk in young Irish Wolfhounds. This discovery, with subsequent development of a genetic screening test, will contribute to selective breeding decisions to decrease osteosarcoma prevalence in the Irish Wolfhound breed. Findings can then be applied to other osteosarcoma-predisposed breeds. The genomic research approach will also have substantial impact in method development for other genetic studies of rare diseases in dogs or diseases in rare breeds.
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Publication(s)
Momen, M., Kohler, N. L., Binversie, E. E., Dentino, M., & Sample, S. J. (2021). Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information. Canine Medicine and Genetics, 8(1), 9. https://doi.org/10.1186/s40575-021-00109-y
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Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
