1609: Use of Probiotic to Reduce the Symptoms of Inflammatory Bowel Disease

Grant Status: Open

Grant Amount: $97,416
Dr. Albert E. Jergens, DVM, PhD, Iowa State University
January 1, 2012 - December 31, 2014
Sponsor(s): American Belgian Malinois Club, American German Shepherd Dog Charitable Foundation, Inc., American Whippet Club, Belgian Sheepdog Club of America, Inc., Briard Club of America Health & Education Trust, English Cocker Spaniel Club of America, English Setter Association of America, Inc., Health & Rescue Foundation of the Petit Basset Griffon Vendeen Club of America, Irish Setter Club of America Foundation, Keeshond Anonymous Fund, Labrador Retriever Club, Inc., National Beagle Club, Old English Sheepdog Club of America, Papillon Club of America, Samoyed Club of America Education & Research Foundation, Siberian Husky Club of America, Westie Foundation of America, Inc., Yorkshire Terrier Club of America
Breed(s): Soft Coated Wheaten Terrier, Basenji, German Shepherd Dog, French Bulldog, Chinook, Boxer
Research Program Area: Gastrointestinal Disease

Abstract

Idiopathic inflammatory bowel disease (IBD) is a common cause of chronic gastrointestinal disease in dogs. Accumulating evidence in human IBD and animal models suggests that imbalances in composition of the intestinal microbiota contribute to the pathogenesis of chronic intestinal inflammation. Recent studies have also shown that dogs with IBD have distinctly different duodenal microbial communities compared to healthy dogs. Current treatments for IBD include the administration of nonspecific anti-inflammatory drugs which may confer serious side effects and do not address the underlying basis for disease, namely, altered microbial composition. Use of probiotics (viable, non-pathogenic bacteria that exert health benefits beyond basic nutrition) offers an attractive, physiologic, and non-toxic alternative to shift the balance to protective species and treat IBD. The aim of the proposed study is to investigate the clinical, microbiologic, and anti-inflammatory effects of probiotic VSL#3 in the treatment of canine IBD. These studies will provide highly relevant insight into the anti-inflammatory effects of probiotics for treatment of human and canine IBD.

Publication(s)

- Otoni, R. Atilmann, M. Garcia-Sancho, et al. Serologic and fecal markers in prediction of acute disease course in canine chronic enteropathies. J Vet Intern Med 2012; 26:768-769. - Slovak et al. Inter- and intra-observer assessment in the endoscopic

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