Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 02336 Research Program Area: Ophthalmology |
Genetics of Primary Angle Closure Glaucoma in American Cocker Spaniels Fawver, B. Researchers study genetic causes of glaucoma in Cocker Spaniels. Purina Pro Club. Published online Oct 2017. https://purinaproclub.com/resource-library/pro-club-updates/researchers-study-genetic-causes-of-glaucoma-in-cocker-spaniels/ Park, S, MI Casanova, DL Bannasch, NL Daley, S Kim...S Thomasy. Ocular Morphologic Traits in the American Cocker Spaniel May Confer Primary Angle Closure Glaucoma Susceptibility. (2022, May 18). https://doi.org/10.21203/rs.3.rs-1634088/v1 |
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Grant Number: 02773 Research Program Area: Oncology - Osteosarcoma |
Histotripsy for Treatment of Canine Appendicular Osteosarcoma Hendricks-Wenger, A., Arnold, L., Gannon, J., Simon, A., Singh, N., Sheppard, H., Nagai-Singer, M. A., Imran, K. M., Lee, K., Clark-Deener, S., Byron, C., Edwards, M. R., Larson, M. M., Rossmeisl, J. H., Coutermarsh-Ott, S. L., Eden, K., Dervisis, N., Klahn, S., Tuohy, J., … Vlaisavljevich, E. (2022). Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 69(1), 5–26. https://doi.org/10.1109/TUFFC.2021.3110083 Arnold, L., Hendricks-Wenger, A., Coutermarsh-Ott, S., Gannon, J., Hay, A. N., Dervisis, N., Klahn, S., Allen, I. C., Tuohy, J., & Vlaisavljevich, E. (2021). Histotripsy Ablation of Bone Tumors: Feasibility Study in Excised Canine Osteosarcoma Tumors. Ultrasound in Medicine & Biology. https://doi.org/10.1016/j.ultrasmedbio.2021.08.004 Latifi, M., Hay, A., Carroll, J., Dervisis, N., Arnold, L., Coutermarsh-Ott, S. L., Kierski, K. R., Klahn, S., Allen, I. C., Vlaisavljevich, E., & Tuohy, J. (2021). Focused ultrasound tumour ablation in small animal oncology. Veterinary and Comparative Oncology, 19(3), 411–419. https://doi.org/10.1111/vco.12742 |
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Grant Number: 02604 Research Program Area: Neurology |
Clinical, Pathologic, and Molecular Genetics Investigations of Canine Lysosomal Storage Diseases and Related Diseases Guo, J., Johnson, G. S., Cook, J., Harris, O. K., Mhlanga-Mutangadura, T., Schnabel, R. D., … Katz, M. L. (2019). Neuronal ceroid lipofuscinosis in a German Shorthaired Pointer associated with a previously reported CLN8 nonsense variant. Molecular Genetics and Metabolism Reports, 21, 100521. https://doi.org/10.1016/j.ymgmr.2019.100521
Bullock, G., Johnson, G. S., Mhlanga-Mutangadura, T., Petesch, S. C., Thompson, S., Goebbels, S., & Katz, M. L. (2022). Lysosomal Storage Disease Associated with a CNP Sequence Variant in Dalmatian Dogs. Gene, 146513. https://doi.org/10.1016/j.gene.2022.146513 |
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Grant Number: 02661 Research Program Area: Cardiology |
Investigation into Diet-Associated Dilated Cardiomyopathy in Dogs Adin, D., Freeman, L., Stepien, R., Rush, J. E., Tjostheim, S., Kellihan, H., Aherne, M., Vereb, M., & Goldberg, R. (2021). Effect of type of diet on blood and plasma taurine concentrations, cardiac biomarkers, and echocardiograms in 4 dog breeds. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16075 Haimovitz, D., Vereb, M., Freeman, L., Goldberg, R., Lessard, D., Rush, J., & Adin, D. (2022). Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16416 |
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Grant Number: 02383 Research Program Area: Tick-Borne Disease Initiative |
Identifying Cellular Mechanisms of Inflammation During Canine Tick‐Borne Diseases Scorza, B. M., Mahachi, K. G., Cox, A. D., Toepp, A. J., Pessoa-Pereira, D., Tyrrell, P., Buch, J., Foltz, J. A., Lee, D., & Petersen, C. A. (2022). Role of NK-Like CD8+ T Cells during Asymptomatic Borrelia burgdorferi Infection. Infection and Immunity, 0(0), e00555-21. https://doi.org/10.1128/iai.00555-21 |
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Grant Number: 02234-MOU Research Program Area: Oncology - Hemangiosarcoma |
A Novel Approach for Prevention of Canine Hemangiosarcoma Sarver, A. L., Makielski, K. M., DePauw, T. A., Schulte, A. J., & Modiano, J. F. (2022). Increased risk of cancer in dogs and humans: A consequence of recent extension of lifespan beyond evolutionarily determined limitations? Aging and Cancer. https://doi.org/10.1002/aac2.12046 Borgatti, A., Fieberg, A., Winter, A. L., Stuebner, K., Taras, E., Todhunter, D., Masyr, A., Rendhal, A., Vallera, D. A., Koopmeiners, J. S., & Modiano, J. F. (2020). Impact of Repeated Cycles of EGF Bispecific Angiotoxin (eBAT) Administered at a Reduced Interval from Doxorubicin Chemotherapy in Dogs with Splenic Hemangiosarcoma. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12590 |
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Grant Number: 02709 Research Program Area: Gastrointestinal Disease |
Identification of Genetic Risk Factors Contributing to Gastrointestinal Motility Disorders Bell, S. M., Evans, J. M., Evans, K. M., Tsai, K. L., Noorai, R. E., Famula, T. R., Holle, D. M., & Clark, L. A. (2022). Congenital idiopathic megaesophagus in the German shepherd dog is a sex-differentiated trait and is associated with an intronic variable number tandem repeat in Melanin-Concentrating Hormone Receptor 2. PLOS Genetics, 18(3), e1010044. https://doi.org/10.1371/journal.pgen.1010044 |
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Grant Number: 02052 Research Program Area: Immunology and Infectious Disease |
Defining the Mechanism of Severe, Life-Threatening Bleeding Disorders in Dogs Brooks, M. B., Maruyama, H., Cremer, S. E., Goggs, R., Forman, M. A., Koch, M., Merriam, J., Makielski, K., Viall, A., & LeVine, D. N. (2022). Preliminary evaluation of a flow cytometric assay with microsphere controls for the detection of platelet-bound antibodies in canine immune thrombocytopenia. Veterinary Clinical Pathology. https://doi.org/10.1111/vcp.13093 Makielski, K. M., Brooks, M. B., Wang, C., Cullen, J. N., O’Connor, A. M., & LeVine, D. N. (2018). Development and implementation of a novel immune thrombocytopenia bleeding score for dogs. Journal of Veterinary Internal Medicine, 32(3), 1041–1050. https://doi.org/10.1111/jvim.15089 |
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Grant Number: 02806-MOU Research Program Area: Oncology - Hemangiosarcoma |
Strategic Prevention of Canine Hemangiosarcoma: Lifetime Follow-Up Sarver, A. L., Makielski, K. M., DePauw, T. A., Schulte, A. J., & Modiano, J. F. (2022). Increased risk of cancer in dogs and humans: A consequence of recent extension of lifespan beyond evolutionarily determined limitations? Aging and Cancer. https://doi.org/10.1002/aac2.12046 |
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Grant Number: 02536-MOU Research Program Area: Blood Disorders |
Immunoprofiling to Combat Canine Immune Thrombocytopenia Brooks, M. B., Maruyama, H., Cremer, S. E., Goggs, R., Forman, M. A., Koch, M., Merriam, J., Makielski, K., Viall, A., & LeVine, D. N. (2022). Preliminary evaluation of a flow cytometric assay with microsphere controls for the detection of platelet-bound antibodies in canine immune thrombocytopenia. Veterinary Clinical Pathology. https://doi.org/10.1111/vcp.13093 |
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Grant Number: 02653-A Research Program Area: Dermatology and Allergic Disease |
Evaluation of the Serum and Cutaneous Levels of Chemokines in Atopic Dogs Santoro, D., Archer, L., & Chong, E. (2022). Evaluation of cutaneous and circulating (serum and exosomes) levels of chemokines (CCL17, CCL22, CCL27 and CCL28) in atopic dogs and their correlation with severity of the disease. Veterinary Dermatology. https://doi.org/10.1111/vde.13061 |
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Grant Number: 02838 Research Program Area: Immunology and Infectious Disease |
Standardization of rLiNTPDase2 and Derived Chimeras as Antigens on Immunochromatographic Assay for Diagnosis of Canine Visceral Leishmaniasis de Castro, R. B., de Souza, A. C. A., Pavione, N. da R. T., de Moraes, J. V. B., Ribeiro, I. C., de Melo Agripino, J., Bressan, G. C., de Souza Vasconcellos, R., Silva-Júnior, A., & Fietto, J. L. R. (2022). Urea, salts, and Tween 20 influence on adsorption of IgG and Leishmania rNTPDase2 to nitrocellulose. Analytical Biochemistry, 114648. https://doi.org/10.1016/j.ab.2022.114648 |
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Grant Number: 02407-A Research Program Area: Immunology and Infectious Disease |
In vitro Efficacy of Nano-sulfur Against Planktonic and Biofilm State of Resistant Bacteria Kher, L., Santoro, D., Kelley, K., Gibson, D., & Schultz, G. (2022). Effect of Nanosulfur Against Multidrug-Resistant Staphylococcus pseudintermedius and Pseudomonas aeruginosa. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-022-11872-8 |
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Grant Number: 02519 Research Program Area: Tick-Borne Disease Initiative , Oncology - Hemangiosarcoma |
Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas within and between Geographic Locations Lashnits, E., Neupane, P., Bradley, J. M., Richardson, T., Maggi, R. G., & Breitschwerdt, E. B. (2021). Comparison of Serological and Molecular Assays for Bartonella Species in Dogs with Hemangiosarcoma. Pathogens, 10(7), 794. https://doi.org/10.3390/pathogens10070794 Lashnits, E., Neupane, P., Bradley, J. M., Richardson, T., Thomas, R., Linder, K. E., Breen, M., Maggi, R. G., & Breitschwerdt, E. B. (2020). Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States. PLOS ONE, 15(1), e0227234. https://doi.org/10.1371/journal.pone.0227234 Maggi, R. G., Richardson, T., Breitschwerdt, E. B., & Miller, J. C. (2020). Development and validation of a droplet digital PCR assay for the detection and quantification of Bartonella species within human clinical samples. Journal of Microbiological Methods, 176, 106022. https://doi.org/10.1016/j.mimet.2020.106022 Neupane, P., Sevala, S., Balakrishnan, N., Marr, H., Wilson, J., Maggi, R., Birkenheuer, A., Lappin, M., Chomel, B., & Breitschwerdt, E. B. (2020). Validation of Bartonella henselae Western Immunoblotting for Serodiagnosis of Bartonelloses in Dogs. Journal of Clinical Microbiology. https://doi.org/10.1128/JCM.01335-19 |
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Grant Number: 02502 Research Program Area: Oncology - Lymphoma |
Precision Medicine for Canine Lymphoma Wang, G., Wu, M., Durham, A. C., Mason, N. J., & Roth, D. B. (2021). Canine Oncopanel: A capture-based, NGS platform for evaluating the mutational landscape and detecting putative driver mutations in canine cancers. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12746 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
