Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 02404-A Research Program Area: Immunology and Infectious Disease |
The Impact of Lidocaine Administration on Natural Killer Cell Populations in Canine Sepsis None at this time. |
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Grant Number: 2336 Research Program Area: Ophthalmology |
Genetics of Primary Angle Closure Glaucoma in American Cocker Spaniels None at this time. |
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Grant Number: 02336 Research Program Area: Ophthalmology |
Genetics of Primary Angle Closure Glaucoma in American Cocker Spaniels Fawver, B. Researchers study genetic causes of glaucoma in Cocker Spaniels. Purina Pro Club. Published online Oct 2017. https://purinaproclub.com/resource-library/pro-club-updates/researchers-study-genetic-causes-of-glaucoma-in-cocker-spaniels/ Fawver, B. Dog Update: Primary angle-closure glaucoma is focus of genetic studies in dogs.https://www.purinaproclub.com/resources/dog-articles/breed-updates/dog-update-spring-2019 Park, S, MI Casanova, DL Bannasch, NL Daley, S Kim...S Thomasy. Ocular Morphologic Traits in the American Cocker Spaniel May Confer Primary Angle Closure Glaucoma Susceptibility. (2022, May 18). https://doi.org/10.21203/rs.3.rs-1634088/v1 Gomes, F. E., Casanova, M. I., Mouttham, L., Bannasch, D. L., Park, S., Kim, S., Young, L. J., Daley, N. L., Thomasy, S. M., Castelhano, M. G., Ledbetter, E. C., Holmberg, B., Boyd, R., Woerdt, A. V. D., McDonald, J., & Hayward, J. J. (2022). A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels. American Journal of Veterinary Research, 1(aop), 1–8. https://doi.org/10.2460/ajvr.22.07.0106 |
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Grant Number: 02383 Research Program Area: Tick-Borne Disease Initiative |
Identifying Cellular Mechanisms of Inflammation During Canine Tick‐Borne Diseases Scorza, B. M., Mahachi, K. G., Cox, A. D., Toepp, A. J., Pessoa-Pereira, D., Tyrrell, P., Buch, J., Foltz, J. A., Lee, D., & Petersen, C. A. (2022). Role of NK-Like CD8+ T Cells during Asymptomatic Borrelia burgdorferi Infection. Infection and Immunity, 0(0), e00555-21. https://doi.org/10.1128/iai.00555-21 |
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Grant Number: 02669-A Research Program Area: Reproductive Conditions |
Lipid Composition and Lipid Droplet Dynamics in Canine Pyometra Affected Endometria Leitner, N., Hlavaty, J., Heider, S., Ertl, R., Gabriel, C., & Walter, I. (2022). Lipid droplet dynamics in healthy and pyometra-affected canine endometrium. BMC Veterinary Research, 18(1), 221. https://doi.org/10.1186/s12917-022-03321-5 |
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Grant Number: 02758 Research Program Area: Oncology |
Optical Coherence Tomography for Margin Evaluation of Canine Skin and Subcutaneous Neoplasms
Cheng, E., Jennings, R. N., Chen, C. L., Biggo, M. R., Erickson, A. K., Dornbusch, J. A., Linn, S. C., Lapsley, J., Alva, B. M., Lorbach, J. N., Premanandan, C., & Selmic, L. E. (2022). Optical coherence tomography for surgical margin evaluation of excised canine cutaneous and subcutaneous tumors. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12844 |
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Grant Number: 2614 Research Program Area: Epilepsy Initiative |
Refining the Genetic Linkage For Idiopathic Epilepsy in the Belgian Tervuren and Sheepdog Belanger, J. M., Heinonen, T., Famula, T. R., Mandigers, P. J. J., Leegwater, P. A., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2022). Validation of a Chromosome 14 Risk Haplotype for Idiopathic Epilepsy in the Belgian Shepherd Dog Found to Be Associated with an Insertion in the RAPGEF5 Gene. Genes, 13(7), 1124. https://doi.org/10.3390/genes13071124 Belanger, J. M., Famula, T. R., Gershony, L. C., Palij, M. K., & Oberbauer, A. M. (2020). Genome-wide association analysis of idiopathic epilepsy in the Belgian Shepherd. Canine Medicine and Genetics, 7(1), 12. https://doi.org/10.1186/s40575-020-00091-x Oberbauer, A. M., Belanger, J. M., Grossman, D. I., Regan, K. R., & Famula, T. R. (2010). Genome-wide linkage scan for loci associated with epilepsy in Belgian Shepherd Dogs. BMC Genetics, 11, 35. https://doi.org/10.1186/1471-2156-11-35 >Seppälä, E. H., Koskinen, L. L. E., Gulløv, C. H., Jokinen, P., Karlskov-Mortensen, P., Bergamasco, L., … Lohi, H. (2012). Identification of a Novel Idiopathic Epilepsy Locus in Belgian Shepherd Dogs. PLoS ONE, 7(3), e33549. https://doi.org/10.1371/journal.pone.0033549 |
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Grant Number: 01844 Research Program Area: Kidney & Urological Disease |
Treatment of Urinary Incontinence with Multipotent Muscle Cells: A Regenerative Medicine Approach to a Common Canine Health Problem Vaden, S. L., Mathews, K. G., Yoo, J., Williams, J. K., Harris, T., Secoura, P., Robertson, J., Gleason, K. L., Reynolds, H., & Piedrahita, J. (2022). The use of autologous skeletal muscle progenitor cells for adjunctive treatment of presumptive urethral sphincter mechanism incompetence in female dogs. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16505 Vaden, S. L., & Elliott, J. (2016). Management of Proteinuria in Dogs and Cats with Chronic Kidney Disease. Vet Clin North Am Small Anim Pract, 46(6), 1115-1130. doi:10.1016/j.cvsm.2016.06.009 |
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Grant Number: 02855-A Research Program Area: Oncology |
Repurposing Drugs to Modulate Myeloid-derived Suppressor Cells (MDSCs) in Canine Soft Tissue Sarcomas Soileau, A. M., Quick, C. N., Moeller, C. E., Schaumburg, J. C., & Withers, S. S. (2022). The Effect of Arginase on Canine T-Lymphocyte Functions and its Modulation by All-Trans Retinoid Acid (ATRA) in Canine Monocyte-Derived Macrophages. Veterinary Sciences, 9(7), 374. https://doi.org/10.3390/vetsci9070374 |
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Grant Number: 02553 Research Program Area: Tick-Borne Disease Initiative |
Targeted Next Generation Sequencing Panel for Comprehensive Testing of Vector-borne Pathogens
Kattoor, J. J., Nikolai, E., Qurollo, B., & Wilkes, R. P. (2022). Targeted Next-Generation Sequencing for Comprehensive Testing for Selected Vector-Borne Pathogens in Canines. Pathogens, 11(9), 964. https://doi.org/10.3390/pathogens11090964 |
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Grant Number: 02821-A Research Program Area: Immunology and Infectious Disease |
Investigating the Role of Aedes aegypti in Dog Heartworm Transmission in Communities along the U.S.-Mexico Border Scavo, N. A., Zecca, I. B., Sobotyk, C., Saleh, M. N., Lane, S. K., Olson, M. F., Hamer, S. A., Verocai, G. G., & Hamer, G. L. (2022). High prevalence of canine heartworm, Dirofilaria immitis, in pet dogs in south Texas, USA, with evidence of Aedes aegypti mosquitoes contributing to transmission. Parasites & Vectors, 15(1), 407. https://doi.org/10.1186/s13071-022-05514-1 |
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Grant Number: 02768 Research Program Area: Oncology - Osteosarcoma |
Defining the Functional Consequences and Therapeutic Vulnerability of Dystrophin Alterations in Canine Osteosarcoma Megquier, K., Turner-Maier, J., Morrill, K., Li, X., Johnson, J., Karlsson, E. K., London, C. A., & Gardner, H. L. (2022). The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations. PLOS ONE, 17(9), e0274383. https://doi.org/10.1371/journal.pone.0274383 |
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Grant Number: 1613 Research Program Area: Epilepsy Initiative |
Development of a Genetic Marker for Idiopathic Epilepsy in the Belgian Tervuren and Belgian Sheepdog Belanger, J. M., Heinonen, T., Famula, T. R., Mandigers, P. J. J., Leegwater, P. A., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2022). Validation of a Chromosome 14 Risk Haplotype for Idiopathic Epilepsy in the Belgian Shepherd Dog Found to Be Associated with an Insertion in the RAPGEF5 Gene. Genes, 13(7), 1124. https://doi.org/10.3390/genes13071124 Belanger, J. M., Famula, T. R., Gershony, L. C., Palij, M. K., & Oberbauer, A. M. (2020). Genome-wide association analysis of idiopathic epilepsy in the Belgian Shepherd. Canine Medicine and Genetics, 7(1), 12. https://doi.org/10.1186/s40575-020-00091-x Oberbauer, A. M. (2003). The Genetics of Epilepsy in the Belgian Tervuren and Sheepdog. Journal of Heredity, 94(1), 57–63. https://doi.org/10.1093/jhered/esg010 Oberbauer, Anita M., Belanger, J. M., Grossman, D. I., Regan, K. R., & Famula, T. R. (2010). Genome-wide linkage scan for loci associated with epilepsy in Belgian Shepherd Dogs. BMC Genetics, 11, 35. https://doi.org/10.1186/1471-2156-11-35 |
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Grant Number: 02157-MOU Research Program Area: Neurology |
Genomics of Deafness in the Dalmatian Haase, B., Willet, C. E., Chew, T., Samaha, G., Child, G., & Wade, C. M. (2022). De-novo and genome-wide meta-analyses identify a risk haplotype for congenital sensorineural deafness in Dalmatian dogs. Scientific Reports, 12(1), 15439. https://doi.org/10.1038/s41598-022-19535-4 Brancalion, L., Haase, B., Mazrier, H., Willet, C. E., Lindblad‐Toh, K., Lingaas, F., & Wade, C. M. (2021). Roan, ticked and clear coat patterns in the canine are associated with three haplotypes near usherin on CFA38. Animal Genetics. https://doi.org/10.1111/age.13040 Brancalion, L., Haase, B., Willet, C. E., & Wade, C. M. (2021). Sequence variants of the canine melanocyte inducing transcription factor (MITF) locus reveal a common MITF-A processed pseudogene. Animal Genetics, 52(5), 777–778. https://doi.org/10.1111/age.13106 |
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Grant Number: 02653-A Research Program Area: Dermatology and Allergic Disease |
Evaluation of the Serum and Cutaneous Levels of Chemokines in Atopic Dogs Santoro, D., Archer, L., & Chong, E. (2022). Evaluation of cutaneous and circulating (serum and exosomes) levels of chemokines (CCL17, CCL22, CCL27 and CCL28) in atopic dogs and their correlation with severity of the disease. Veterinary Dermatology. https://doi.org/10.1111/vde.13061 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
