Peer-Reviewed Publications Resulting from CHF-funded Grants

We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research.  By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.

You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.

To browse publications by year you may also wish to view our Impact Report.

Research Program Area
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Grant Number: 02204-T

Research Program Area: Oncology

Using Enhanced Imaging to Evaluate Tumor Margins for Canine Mammary Cancer and Soft Tissue Sarcoma

Ye, Y., Sun, W. W., Xu, R. X., Selmic, L. E., & Sun, M. (2021). Intraoperative assessment of canine soft tissue sarcoma by deep learning enhanced optical coherence tomography. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12747

Lages, M., & Selmic, L. E. (2021). Exploring optical coherence tomography imaging depth to differentiate tissues at surgical margins. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12745

Dornbusch, J. A., Selmic, L. E., Huang, P.-C., Samuelson, J. P., McLaughlin, E. M., Wavreille, V. A., Ogden, J. A., Abrams, B., Kalamaras, A., Green, E., Hostnik, E. T., Every, L., Fuerst, J. A., Jennings, R., Premanandan, C., Lorbach, J. N., Linn, S. C., Alex, A., Sorrells, J. E., … Boppart, S. A. (2020). Diagnostic accuracy of optical coherence tomography for assessing surgical margins of canine soft tissue sarcomas in observers of different specialties. Veterinary Surgery. https://doi.org/10.1111/vsu.13510

Fabelo, C., Selmic, L. E., Huang, P.-C., Samuelson, J. P., Reagan, J. K., Kalamaras, A., Wavreille, V., Monroy, G. L., Marjanovic, M., & Boppart, S. A. (2020). Evaluating optical coherence tomography for surgical margin assessment of canine mammary tumors. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12632

Mesa, K. J., Selmic, L. E., Pande, P., Monroy, G. L., Reagan, J., Samuelson, J., … Boppart, S. A. (2017). Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification. Lasers in Surgery and Medicine, 49(3), 240–248. https://doi.org/10.1002/lsm.22633

Selmic, L. E., Samuelson, J., Reagan, J. K., Mesa, K. J., Driskell, E., Li, J., … Boppart, S. A. (2018). Intraoperative imaging of surgical margins of canine soft tissue sarcoma using optical coherence tomography. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12448

Holt, D., Singhal, S., & Selmic, L. E. (2019). Near‐infrared imaging and optical coherence tomography for intraoperative visualization of tumors. Veterinary Surgery, 1–11. https://doi.org/10.1111/vsu.13332

Grant Number: 01986

Research Program Area: Hepatic Disease

Profiling the Metabolic and Lipid Imbalances that are Causative of Gallbladder Disease in Dogs

Lindaberry, C., Vaden, S., Aicher, K. M., Seiler, G., Robertson, J., Cianciolo, R., Yang, C., & Gookin, J. L. (2021). Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16051

Aicher, K., Cullen, J., Gookin, J., Seiler, G., Lunn, K., Mathews, K., & Correa, M. (2016). HP02 Association of gallbladder mucocele formation with occult hypothyroidism in dogs: A matched case-controlled study. Journal of Veterinary Internal Medicine. 40(4), 1407-1519. https://doi.org/10.1111/jvim.13952

Aicher, K. M., Cullen, J. M., Seiler, G. S., Lunn, K. F., Mathews, K. G., & Gookin, J. L. (2019). Investigation of adrenal and thyroid gland dysfunction in dogs with ultrasonographic diagnosis of gallbladder mucocele formation. PLOS ONE, 14(2), e0212638. https://doi.org/10.1371/journal.pone.0212638

Gookin, J. L., Correa, M. T., Peters, A., Malueg, A., Mathews, K. G., Cullen, J., & Seiler, G. (2015). Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study. Journal of Veterinary Internal Medicine, 29(6), 1464-1472. https://doi.org/10.1111/jvim.13649

Gookin, J. L., Mathews, K. G., Cullen, J., & Seiler, G. (2018). Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation. PLOS ONE, 13(1), e0191076. https://doi.org/10.1371/journal.pone.0191076

Grant Number: 02162-MOU

Research Program Area: Neurology

Defining The Genetic Foundations of Chiari-Like Malformation and Syringomyelia as a Tool to Better Treat Neuropathic Pain in the Dog

Sparks, C. R., Woelfel, C., Robertson, I., & Olby, N. J. (2021). Association between filum terminale internum length and pain in Cavalier King Charles spaniels with and without syringomyelia. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16023

Sparks, C. R., Cerda‐Gonzalez, S., Griffith, E. H., Lascelles, B. D. X., & Olby, N. J. (2018). Questionnaire-based Analysis of Owner-reported Scratching and Pain Signs in Cavalier King Charles Spaniels Screened for Chiari-like Malformation and Syringomyelia. Journal of Veterinary Internal Medicine, 32(1), 331–339. https://doi.org/10.1111/jvim.14856

Sparks, C. R., Robertson, I., & Olby, N. J. (2019). Morphometric analysis of spinal cord termination in Cavalier King Charles Spaniels. Journal of Veterinary Internal Medicine, 1–9. https://doi.org/10.1111/jvim.15437

Sparks, Courtney R., Gorney, A., Williams, K., Griffith, E. H., Cerda‐Gonzalez, S., Lascelles, B. D. X., & Olby, N. J. (2018). Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari-like malformations and syringomyelia. Journal of Veterinary Internal Medicine, 32(6), 2021–2028. https://doi.org/10.1111/jvim.15297

Grant Number: 02518

Research Program Area: Behavior

The Effects of Early Life Experience on Working Dog Temperament and Cognition

Bray, E. E., Gnanadesikan, G. E., Horschler, D. J., Levy, K. M., Kennedy, B. S., Famula, T. R., & MacLean, E. L. (2021). Early-emerging and highly heritable sensitivity to human communication in dogs. Current Biology, 31. https://doi.org/10.1016/j.cub.2021.04.055

Bray, E. E., Gruen, M. E., Gnanadesikan, G. E., Horschler, D. J., Levy, K. M., Kennedy, B. S., Hare, B. A., & MacLean, E. L. (2020). Dog cognitive development: A longitudinal study across the first 2 years of life. Animal Cognition. https://doi.org/10.1007/s10071-020-01443-7

Bray, E. E., Gruen, M. E., Gnanadesikan, G. E., Horschler, D. J., Levy, K. M., Kennedy, B. S., Hare, B. A., & MacLean, E. L. (2020). Cognitive characteristics of 8- to 10-week-old assistance dog puppies. Animal Behaviour, 166, 193–206. https://doi.org/10.1016/j.anbehav.2020.05.019

Bray, E. E., Levy, K. M., Kennedy, B. S., Duffy, D. L., Serpell, J. A., & MacLean, E. L. (2019). Predictive Models of Assistance Dog Training Outcomes Using the Canine Behavioral Assessment and Research Questionnaire and a Standardized Temperament Evaluation. Frontiers in Veterinary Science, 6 (49). https://doi.org/10.3389/fvets.2019.00049

Grant Number: 02388-MOU

Research Program Area: Cardiology

Genetic Markers for Familial Subvalvular Aortic Stenosis in Newfoundlands

Ontiveros, E. S., & Stern, J. A. (2021). Genetics of canine subvalvular aortic stenosis (SAS). Canine Medicine and Genetics, 8(1), 4. https://doi.org/10.1186/s40575-021-00103-4

Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052

Grant Number: 02368

Research Program Area: Cardiology

Identification of Mitral Valve Disease DNA variants in Miniature Schnauzers

Williams, B., Friedenberg, S. G., Keene, B. W., Tou, S. P., DeFrancesco, T. C., & Meurs, K. M. (2021). Use of whole genome analysis to identify shared genomic variants across breeds in canine mitral valve disease. Human Genetics. https://doi.org/10.1007/s00439-021-02297-w

Grant Number: 02520-MOU

Research Program Area: Cardiology

Identification of Genetic Markers for Familial Subvalvular Aortic Stenosis in Rottweilers

Ontiveros, E. S., & Stern, J. A. (2021). Genetics of canine subvalvular aortic stenosis (SAS). Canine Medicine and Genetics, 8(1), 4. https://doi.org/10.1186/s40575-021-00103-4

Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052

Grant Number: 02456-A

Research Program Area: Oncology

The Impact of Intravenous Anesthetic Agents on Canine Natural Killer Cell

Barr, C. A., Alvarado, F., Chang, Y.-M., Luo, J., & Garden, O. A. (2021). The impact of alfaxalone, propofol and ketamine on canine peripheral blood lymphocyte cytotoxicity in vitro. Research in Veterinary Science, 136, 182–184. https://doi.org/10.1016/j.rvsc.2021.02.019

Grant Number: 02528

Research Program Area: Tick-Borne Disease Initiative

Developing a Next Generation Sequencing Diagnostic Platform for Tickborne Diseases

Oney, K., Koo, M., Roy, C., Ren, S., Qurollo, B., Juhasz, N. B., Vasconcelos, E. J. R., Oakley, B., & Diniz, P. P. V. P. (2021). Evaluation of a commercial microbial enrichment kit used prior DNA extraction to improve the molecular detection of vector-borne pathogens from naturally infected dogs. Journal of Microbiological Methods, 106163. https://doi.org/10.1016/j.mimet.2021.106163

Grant Number: 02172-MOU

Research Program Area: Neurology

Understanding Hereditary Deafness in Dogs

Seddon, J. M., Fortes, M., Kelly-Smith, M., Sommerlad, S. F., Hayward, J. J., Burmeister, L., Risio, L. D., Mellersh, C., Freeman, J., & Strain, G. M. (2021). Deafness in Australian Cattle Dogs associated to QTL on chromosome 20 in genome-wide association study analyses. Animal Genetics. https://doi.org/10.1111/age.13115

Kelly-Smith, M., & Strain, G. M. (2020). STRING Data Mining of GWAS Data in Canine Hereditary Pigment-Associated Deafness. Veterinary and Animal Science, 100118. https://doi.org/10.1016/j.vas.2020.100118

Hayward, J. J., Kelly-Smith, M., Boyko, A. R., Burmeister, L., De Risio, L., Mellersh, C., Freeman, J., & Strain, G. M. (2020). A genome-wide association study of deafness in three canine breeds. PLOS ONE, 15(5), e0232900. https://doi.org/10.1371/journal.pone.0232900

Grant Number: 02700

Research Program Area: Behavior

Longitudinal Comparison of Cognitive and Emotional Development in Assistance Dog Puppies

Salomons, H., Smith, K. C. M., Callahan-Beckel, M., Callahan, M., Levy, K., Kennedy, B. S., Bray, E. E., Gnanadesikan, G. E., Horschler, D. J., Gruen, M., Tan, J., White, P., vonHoldt, B. M., MacLean, E. L., & Hare, B. (2021). Cooperative Communication with Humans Evolved to Emerge Early in Domestic Dogs. Current Biology. https://doi.org/10.1016/j.cub.2021.06.051

Grant Number: 02327-MOU

Research Program Area: Cardiology

Identification of Genetic Markers for Familial Subvalvular Aortic Stenosis in Bullmastiffs

Ontiveros, E. S., & Stern, J. A. (2021). Genetics of canine subvalvular aortic stenosis (SAS). Canine Medicine and Genetics, 8(1), 4. https://doi.org/10.1186/s40575-021-00103-4

Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052

Grant Number: 02380-A

Research Program Area: Immunology and Infectious Disease

Estimating Prevalence and Identifying Risk Factors for Canine Leptospirosis in North America

Smith, A. M., Stull, J. W., Evason, M. D., Weese, J. S., Wittum, T. E., Szlosek, D., & Arruda, A. G. (2021). Investigation of spatio-temporal clusters of positive leptospirosis polymerase chain reaction test results in dogs in the United States, 2009 to 2016. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16060

-Leptospirosis Information for Dog Owners

Smith, A. M., Arruda, A. G., Evason, M. D., Weese, J. S., Wittum, T. E., Szlosek, D., & Stull, J. W. (2019). A cross-sectional study of environmental, dog, and human-related risk factors for positive canine leptospirosis PCR test results in the United States, 2009 to 2016. BMC Veterinary Research, 15(1), 412. doi.org/10.1186/s12917-019-2148-6

Grant Number: 02521-MOU

Research Program Area: Cardiology

Identification of Genetic Markers for Familial Subvalvular Aortic Stenosis in Golden Retrievers

Ontiveros, E. S., & Stern, J. A. (2021). Genetics of canine subvalvular aortic stenosis (SAS). Canine Medicine and Genetics, 8(1), 4. https://doi.org/10.1186/s40575-021-00103-4

Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052

Grant Number: 2292

Research Program Area: Tick-Borne Disease Initiative

Broad-Range Detection of Canine Tick-Borne Disease and Improved Diagnostics Using Next-Generation Sequencing

Oney, K., Koo, M., Roy, C., Ren, S., Qurollo, B., Juhasz, N. B., Vasconcelos, E. J. R., Oakley, B., & Diniz, P. P. V. P. (2021). Evaluation of a commercial microbial enrichment kit used prior DNA extraction to improve the molecular detection of vector-borne pathogens from naturally infected dogs. Journal of Microbiological Methods, 106163. https://doi.org/10.1016/j.mimet.2021.106163

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