Peer-Reviewed Publications Resulting from CHF-funded Grants

We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research.  By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.

You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.

To browse publications by year you may also wish to view our Impact Report.

Research Program Area
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Grant Number: 02162-MOU

Research Program Area: Neurology

Defining The Genetic Foundations of Chiari-Like Malformation and Syringomyelia as a Tool to Better Treat Neuropathic Pain in the Dog

Sparks, C. R., Woelfel, C., Robertson, I., & Olby, N. J. (2021). Association between filum terminale internum length and pain in Cavalier King Charles spaniels with and without syringomyelia. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16023

Sparks, C. R., Cerda‐Gonzalez, S., Griffith, E. H., Lascelles, B. D. X., & Olby, N. J. (2018). Questionnaire-based Analysis of Owner-reported Scratching and Pain Signs in Cavalier King Charles Spaniels Screened for Chiari-like Malformation and Syringomyelia. Journal of Veterinary Internal Medicine, 32(1), 331–339. https://doi.org/10.1111/jvim.14856

Sparks, C. R., Robertson, I., & Olby, N. J. (2019). Morphometric analysis of spinal cord termination in Cavalier King Charles Spaniels. Journal of Veterinary Internal Medicine, 1–9. https://doi.org/10.1111/jvim.15437

Sparks, Courtney R., Gorney, A., Williams, K., Griffith, E. H., Cerda‐Gonzalez, S., Lascelles, B. D. X., & Olby, N. J. (2018). Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari-like malformations and syringomyelia. Journal of Veterinary Internal Medicine, 32(6), 2021–2028. https://doi.org/10.1111/jvim.15297

Grant Number: 02456-A

Research Program Area: Oncology

The Impact of Intravenous Anesthetic Agents on Canine Natural Killer Cell

Barr, C. A., Alvarado, F., Chang, Y.-M., Luo, J., & Garden, O. A. (2021). The impact of alfaxalone, propofol and ketamine on canine peripheral blood lymphocyte cytotoxicity in vitro. Research in Veterinary Science, 136, 182–184. https://doi.org/10.1016/j.rvsc.2021.02.019

Grant Number: 02528

Research Program Area: Tick-Borne Disease Initiative

Developing a Next Generation Sequencing Diagnostic Platform for Tickborne Diseases

Oney, K., Koo, M., Roy, C., Ren, S., Qurollo, B., Juhasz, N. B., Vasconcelos, E. J. R., Oakley, B., & Diniz, P. P. V. P. (2021). Evaluation of a commercial microbial enrichment kit used prior DNA extraction to improve the molecular detection of vector-borne pathogens from naturally infected dogs. Journal of Microbiological Methods, 106163. https://doi.org/10.1016/j.mimet.2021.106163

Grant Number: 02380-A

Research Program Area: Immunology and Infectious Disease

Estimating Prevalence and Identifying Risk Factors for Canine Leptospirosis in North America

Smith, A. M., Stull, J. W., Evason, M. D., Weese, J. S., Wittum, T. E., Szlosek, D., & Arruda, A. G. (2021). Investigation of spatio-temporal clusters of positive leptospirosis polymerase chain reaction test results in dogs in the United States, 2009 to 2016. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16060

-Leptospirosis Information for Dog Owners

Smith, A. M., Arruda, A. G., Evason, M. D., Weese, J. S., Wittum, T. E., Szlosek, D., & Stull, J. W. (2019). A cross-sectional study of environmental, dog, and human-related risk factors for positive canine leptospirosis PCR test results in the United States, 2009 to 2016. BMC Veterinary Research, 15(1), 412. doi.org/10.1186/s12917-019-2148-6

Grant Number: 2646

Research Program Area: Musculoskeletal Conditions and Disease

Effect of Hyperthermia on Skeletal Muscle Energy Efficiency

Davis, M. S., & Barrett, M. R. (2021). Effect of conditioning and physiology hyperthermia on canine skeletal muscle mitochondrial oxygen consumption. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00969.2020

Grant Number: 01986

Research Program Area: Hepatic Disease

Profiling the Metabolic and Lipid Imbalances that are Causative of Gallbladder Disease in Dogs

Lindaberry, C., Vaden, S., Aicher, K. M., Seiler, G., Robertson, J., Cianciolo, R., Yang, C., & Gookin, J. L. (2021). Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16051

Aicher, K., Cullen, J., Gookin, J., Seiler, G., Lunn, K., Mathews, K., & Correa, M. (2016). HP02 Association of gallbladder mucocele formation with occult hypothyroidism in dogs: A matched case-controlled study. Journal of Veterinary Internal Medicine. 40(4), 1407-1519. https://doi.org/10.1111/jvim.13952

Aicher, K. M., Cullen, J. M., Seiler, G. S., Lunn, K. F., Mathews, K. G., & Gookin, J. L. (2019). Investigation of adrenal and thyroid gland dysfunction in dogs with ultrasonographic diagnosis of gallbladder mucocele formation. PLOS ONE, 14(2), e0212638. https://doi.org/10.1371/journal.pone.0212638

Gookin, J. L., Correa, M. T., Peters, A., Malueg, A., Mathews, K. G., Cullen, J., & Seiler, G. (2015). Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study. Journal of Veterinary Internal Medicine, 29(6), 1464-1472. https://doi.org/10.1111/jvim.13649

Gookin, J. L., Mathews, K. G., Cullen, J., & Seiler, G. (2018). Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation. PLOS ONE, 13(1), e0191076. https://doi.org/10.1371/journal.pone.0191076

Grant Number: 01889-G

Research Program Area: Oncology

Innovations in Prevention, Diagnosis, and Treatment of Cancer - Goldens Lead the Way

Kim, J. H., Megquier, K., Thomas, R., Sarver, A. L., Song, J. M., Kim, Y. T., Cheng, N., Schulte, A. J., Linden, M. A., Murugan, P., Oseth, L., Forster, C. L., Elvers, I., Swofford, R., Turner-Maier, J., Karlsson, E. K., Breen, M., Lindblad-Toh, K., & Modiano, J. F. (2021). Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0937

Borgatti, A., Fieberg, A., Winter, A. L., Stuebner, K., Taras, E., Todhunter, D., Masyr, A., Rendhal, A., Vallera, D. A., Koopmeiners, J. S., & Modiano, J. F. (2020). Impact of Repeated Cycles of EGF Bispecific Angiotoxin (eBAT) Administered at a Reduced Interval from Doxorubicin Chemotherapy in Dogs with Splenic Hemangiosarcoma. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12590

Borgatti, A., Koopmeiners, J. S., Sarver, A. L., Winter, A. L., Stuebner, K., Todhunter, D., … Vallera, D. A. (2017). Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR. Molecular Cancer Therapeutics, 16(5), 956–965. https://doi.org/10.1158/1535-7163.MCT-16-0637

Elvers, I., Turner-Maier, J., Swofford, R., Koltookian, M., Johnson, J., Stewart, C., … Alföldi, J. (2015). Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background. Genome Research, 25(11), 1634–1645. https://doi.org/10.1101/gr.194449.115

Gorden, B. H., Kim, J.-H., Sarver, A. L., Frantz, A. M., Breen, M., Lindblad-Toh, K., … Dickerson, E. B. (2014). Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization. The American Journal of Pathology, 184(4), 985–995. https://doi.org/10.1016/j.ajpath.2013.12.025

Im, K. S., Graef, A. J., Breen, M., Lindblad-Toh, K., Modiano, J. F., & Kim, J.-H. (2015). Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma: CXCR4/CXCL12 in HSA migration and invasion. Veterinary and Comparative Oncology, 15(2), 315–327. https://doi.org/10.1111/vco.12165

Seelig, D. M., Ito, D., Forster, C. L., Yoon, U. A., Breen, M., Burns, L. J., … Linden, M. A. (2017). Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies. Leukemia & Lymphoma, 58(7), 1702–1710. https://doi.org/10.1080/10428194.2016.1260122

Thomas, R., Borst, L., Rotroff, D., Motsinger-Reif, A., Lindblad-Toh, K., Modiano, J. F., & Breen, M. (2014). Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma. Chromosome Research, 22(3), 305–319. https://doi.org/10.1007/s10577-014-9406-z

Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922

Megquier, K., Turner-Maier, J., Swofford, R., Kim, J.-H., Sarver, A. L., Wang, C., … Lindblad-Toh, K. (2019). Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma. Molecular Cancer Research, 17(12), 2410–2421 https://doi.org/10.1158/1541-7786.MCR-19-0221

Grant Number: 2292

Research Program Area: Tick-Borne Disease Initiative

Broad-Range Detection of Canine Tick-Borne Disease and Improved Diagnostics Using Next-Generation Sequencing

Oney, K., Koo, M., Roy, C., Ren, S., Qurollo, B., Juhasz, N. B., Vasconcelos, E. J. R., Oakley, B., & Diniz, P. P. V. P. (2021). Evaluation of a commercial microbial enrichment kit used prior DNA extraction to improve the molecular detection of vector-borne pathogens from naturally infected dogs. Journal of Microbiological Methods, 106163. https://doi.org/10.1016/j.mimet.2021.106163

Grant Number: 02446

Research Program Area: Oncology

Development of Genetic Biomarkers to Improve Diagnosis and Treatment of Canine Histiocytic Sarcoma

Hédan, B., Cadieu, É., Rimbault, M., Vaysse, A., Citres, C. D. de, Devauchelle, P., Botherel, N., Abadie, J., Quignon, P., Derrien, T., & André, C. (2021). Identification of common predisposing loci to hematopoietic cancers in four dog breeds. PLOS Genetics, 17(4), e1009395. https://doi.org/10.1371/journal.pgen.1009395

Prouteau, A., Denis, J. A., De Fornel, P., Cadieu, E., Derrien, T., Kergal, C., Botherel, N., Ulvé, R., Rault, M., Bouzidi, A., François, R., Dorso, L., Lespagnol, A., Devauchelle, P., Abadie, J., André, C., & Hédan, B. (2021). Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma. Scientific Reports, 11(1), 877. https://doi.org/10.1038/s41598-020-80332-y

Hédan, B., Rault, M., Abadie, J., Ulvé, R., Botherel, N., Devauchelle, P., Copie‐Bergman, C., Cadieu, E., Parrens, M., Alten, J., Zalcman, E. L., Cario, G., Damaj, G., Mokhtari, K., Loarer, F. L., Coulomb‐Lhermine, A., Derrien, T., Hitte, C., Bachelot, L., … André, C. (2020). PTPN11 mutations in canine and human disseminated histiocytic sarcoma. International Journal of Cancer. https://doi.org/10.1002/ijc.32991

Grant Number: 02847-A

Research Program Area: General Canine Health

Assessment of Field Wipe-Down Procedure for Removal of Aerosolized Contaminants on Dogs

Perry, E. B., Discepolo, D. R., Liang, S. Y., & Jenkins, E. K. (2021). Removal of Aerosolized Contaminants from Working Canines via a Field Wipe-Down Procedure. Animals, 11(1), 120. https://doi.org/10.3390/ani11010120

Grant Number: 02157-MOU

Research Program Area: Neurology

Genomics of Deafness in the Dalmatian

Brancalion, L., Haase, B., Mazrier, H., Willet, C. E., Lindblad‐Toh, K., Lingaas, F., & Wade, C. M. (2021). Roan, ticked and clear coat patterns in the canine are associated with three haplotypes near usherin on CFA38. Animal Genetics. https://doi.org/10.1111/age.13040

Grant Number: 00754A

Research Program Area: Oncology

Mapping of the Gene for Transitional Cell Carcinoma in the Scottish Terrier & West Highland White Terrier
Parker, H. G., Dhawan, D., Harris, A. C., Ramos-Vara, J. A., Davis, B. W., Knapp, D. W., & Ostrander, E. A. (2020). RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors BMC Cancer, 20(251). doi.org/10.1186/s12885-020-06737-0

Decker, B., Parker, H. G., Dhawan, D., Kwon, E. M., Karlins, E., Davis, B. W., … Ostrander, E. A. (2015). Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer--Evidence for a Relevant Model System and Urine-Based Diagnostic Test. Molecular Cancer Research, 13(6), 993–1002. https://doi.org/10.1158/1541-7786.MCR-14-0689

Dhawan, D., Ramos-Vara, J. A., Stewart, J. C., Zheng, R., & Knapp, D. W. (2009). Canine invasive transitional cell carcinoma cell lines: In vitro tools to complement a relevant animal model of invasive urinary bladder cancer. Urologic Oncology: Seminars and Original Investigations, 27(3), 284–292. https://doi.org/10.1016/j.urolonc.2008.02.015

Grant Number: 02633

Research Program Area: Immunology and Infectious Disease

Validation and Diagnostic Performance of a Novel Monoclonal Antibody based Histoplasma Urine Immunoassay in Dogs with Histoplasmosis

Clark, K., & Hanzlicek, A. S. (2020). Evaluation of a novel monoclonal antibody-based enzyme immunoassay for detection of Histoplasma antigen in urine of dogs. Journal of Veterinary Internal Medicine, 1–20. https://doi.org/10.1111/jvim.16006

Grant Number: 961

Research Program Area: General Canine Health

Medical Surveillance of Dogs Deployed to the World Trade Center and the Pentagon

Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173

Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734

Hunt, M., Otto, C. M., Serpell, J. A., & Alvarez, J. (2012). Interactions between Handler Well-Being and Canine Health and Behavior in Search and Rescue Teams. Anthrozoös, 25(3), 323–335. https://doi.org/10.2752/175303712X13403555186253

Otto, C. M., Downend, A. B., Moore, G. E., Daggy, J. K., Ranivand, D. L., Reetz, J. A., & Fitzgerald, S. D. (2009). Medical surveillance of search dogs deployed to the World Trade Center and Pentagon: 2001-2006. Journal of Veterinary Behavior, 4(6), 241. https://doi.org/10.1016/j.jveb.2009.04.002

Otto, C. M., Franz, M. A., Kellogg, B., Lewis, R., Murphy, L., & Lauber, G. (2002). Field treatment of search dogs: Lessons learned from the World Trade Center disaster: Field treatment of search dogs. Journal of Veterinary Emergency and Critical Care, 12(1), 33–41. https://doi.org/10.1046/j.1435-6935.2002.00004.x

New article:

Surveillance of Search Dogs | Breeding Better Dogs. (2019). Retrieved November 4, 2019, from https://breedingbetterdogs.com/article/surveillance-search-dogs

Grant Number: 02518

Research Program Area: Behavior

The Effects of Early Life Experience on Working Dog Temperament and Cognition

Bray, E. E., Gruen, M. E., Gnanadesikan, G. E., Horschler, D. J., Levy, K. M., Kennedy, B. S., Hare, B. A., & MacLean, E. L. (2020). Dog cognitive development: A longitudinal study across the first 2 years of life. Animal Cognition. https://doi.org/10.1007/s10071-020-01443-7

Bray, E. E., Gruen, M. E., Gnanadesikan, G. E., Horschler, D. J., Levy, K. M., Kennedy, B. S., Hare, B. A., & MacLean, E. L. (2020). Cognitive characteristics of 8- to 10-week-old assistance dog puppies. Animal Behaviour, 166, 193–206. https://doi.org/10.1016/j.anbehav.2020.05.019

Bray, E. E., Levy, K. M., Kennedy, B. S., Duffy, D. L., Serpell, J. A., & MacLean, E. L. (2019). Predictive Models of Assistance Dog Training Outcomes Using the Canine Behavioral Assessment and Research Questionnaire and a Standardized Temperament Evaluation. Frontiers in Veterinary Science, 6 (49). https://doi.org/10.3389/fvets.2019.00049

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