Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 02487 Research Program Area: Oncology |
OX40 Checkpoint Molecule Targeted Antibodies for Cancer Immunotherapy in Dogs Dow, S. (2020). A Role for Dogs in Advancing Cancer Immunotherapy Research. Frontiers in Immunology, 10. https://doi.org/10.3389/fimmu.2019.02935 |
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Grant Number: 02249-A Research Program Area: Neurology, Epilepsy Initiative |
Studying the Role of the Gastrointestinal Tract in Canine Epilepsy Muñana, K. R., Jacob, M. E., & Callahan, B. J. (2020). Evaluation of fecal Lactobacillus populations in dogs with idiopathic epilepsy: A pilot study. Animal Microbiome, 2(1), 19. https://doi.org/10.1186/s42523-020-00036-6 |
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Grant Number: 00754A Research Program Area: Oncology |
Mapping of the Gene for Transitional Cell Carcinoma in the Scottish Terrier & West Highland White Terrier Parker, H. G., Dhawan, D., Harris, A. C., Ramos-Vara, J. A., Davis, B. W., Knapp, D. W., & Ostrander, E. A. (2020). RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors BMC Cancer, 20(251). doi.org/10.1186/s12885-020-06737-0
Decker, B., Parker, H. G., Dhawan, D., Kwon, E. M., Karlins, E., Davis, B. W., … Ostrander, E. A. (2015). Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer--Evidence for a Relevant Model System and Urine-Based Diagnostic Test. Molecular Cancer Research, 13(6), 993–1002. https://doi.org/10.1158/1541-7786.MCR-14-0689
Dhawan, D., Ramos-Vara, J. A., Stewart, J. C., Zheng, R., & Knapp, D. W. (2009). Canine invasive transitional cell carcinoma cell lines: In vitro tools to complement a relevant animal model of invasive urinary bladder cancer. Urologic Oncology: Seminars and Original Investigations, 27(3), 284–292. https://doi.org/10.1016/j.urolonc.2008.02.015
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Grant Number: 02529 Research Program Area: General Canine Health |
Understanding the Genetics of Adverse Drug Reactions in Sighthounds: Phase II Mealey, K. L., Martinez, S. E., Villarino, N. F., & Court, M. H. (2019). Personalized medicine: going to the dogs? Human Genetics. https://doi.org/10.1007/s00439-019-02020-w
Martinez, S. E., Shi, J., Zhu, H.-J., Jimenez, T. E. P., Zhu, Z., & Court, M. H. (2019). Absolute quantitation of drug metabolizing cytochrome P450 enzymes and accessory proteins in dog liver microsomes using label-free standard-free analysis reveals inter-breed variability. Drug Metabolism and Disposition, dmd.119.088070. https://doi.org/10.1124/dmd.119.088070 Martinez, S. E., Andresen, M. C., Zhu, Z., Papageorgiou, I., & Court, M. H. (2020). Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization. Scientific Reports, 10(69). doi:10.1038/s41598-019-56660-z |
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Grant Number: 2242 Research Program Area: General Canine Health |
Understanding the Genetics of Adverse Drug Reactions in Sighthounds Martinez, S. E., Pandey, A. V., & Court, M. H. (2019). Isoform-Dependent Effects of Cytochrome P450 Oxidoreductase Polymorphisms on Drug Metabolism by Cytochrome P450 Enzymes in Dogs. The FASEB Journal, 33(1_supplement), 506.9-506.9. https://doi.org/10.1096/fasebj.2019.33.1_supplement.506.9
Martinez, S. E., Shi, J., Zhu, H.-J., Jimenez, T. E. P., Zhu, Z., & Court, M. H. (2019). Absolute quantitation of drug metabolizing cytochrome P450 enzymes and accessory proteins in dog liver microsomes using label-free standard-free analysis reveals inter-breed variability. Drug Metabolism and Disposition, dmd.119.088070. https://doi.org/10.1124/dmd.119.088070 Martinez, S. E., Andresen, M. C., Zhu, Z., Papageorgiou, I., & Court, M. H. (2020). Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization. Scientific Reports, 10(69). doi:10.1038/s41598-019-56660-z |
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Grant Number: 01336A Research Program Area: Oncology |
Finding the Mutations that Increase Susceptibility to Transitional Cell Carcinoma in the Scottish Terrier, West Highland Terrier, and Shetland Sheepdog Parker, H. G., Dhawan, D., Harris, A. C., Ramos-Vara, J. A., Davis, B. W., Knapp, D. W., & Ostrander, E. A. (2020). RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors BMC Cancer, 20(251). doi.org/10.1186/s12885-020-06737-0
Parker, H. G., Shearin, A. L., & Ostrander, E. A. (2010). Man’s Best Friend Becomes Biology’s Best in Show: Genome Analyses in the Domestic Dog. Annual Review of Genetics, 44(1), 309–336. https://doi.org/10.1146/annurev-genet-102808-115200 Shearin, A. L., & Ostrander, E. A. (2010). Leading the way: canine models of genomics and disease. Disease Models & Mechanisms, 3(1–2), 27–34. https://doi.org/10.1242/dmm.004358 |
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Grant Number: 01937-B Research Program Area: Gastrointestinal Disease |
Evaluating the Complex Genetic Basis of Bloat
Bell, J. S. (2014). Inherited and Predisposing Factors in the Development of Gastric Dilatation Volvulus in Dogs. Topics in Companion Animal Medicine, 29(3), 60–63. https://doi.org/10.1053/j.tcam.2014.09.002 Sharp, C. R., & Rozanski, E. A. (2014). Cardiovascular and Systemic Effects of Gastric Dilatation and Volvulus in Dogs. Topics in Companion Animal Medicine, 29(3), 67–70. https://doi.org/10.1053/j.tcam.2014.09.007 Sharp, C. R., Rozanski, E. A., Finn, E., & Borrego, E. J. (n.d.). The pattern of mortality in dogs with gastric dilatation and volvulus. Journal of Veterinary Emergency and Critical Care, . https://doi.org/10.1111/vec.12932 |
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Grant Number: 02340 Research Program Area: Ophthalmology |
Clinical and Genetic Background of Progressive Retinal Atrophy in Miniature Schnauzers Kaukonen, M., Quintero, I., Mukarram, A., Hytönen, M. K., Holopainen, S., Wickstrom, K., Kyostila, K., Arumilli, M., Jalomaki, S., Daub, C., Kere, J., Lohi, H., & The DoGA Consortium. (2020). A putative silencer variant in a spontaneous canine model of retinitis pigmentosa. PLOS Genetics, 16(3), e1008659. doi.org/10.1371/journal.pgen.1008659 |
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Grant Number: 02204-T Research Program Area: Oncology |
Using Enhanced Imaging to Evaluate Tumor Margins for Canine Mammary Cancer and Soft Tissue Sarcoma Fabelo, C., Selmic, L. E., Huang, P.-C., Samuelson, J. P., Reagan, J. K., Kalamaras, A., Wavreille, V., Monroy, G. L., Marjanovic, M., & Boppart, S. A. (2020). Evaluating optical coherence tomography for surgical margin assessment of canine mammary tumors. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12632 Mesa, K. J., Selmic, L. E., Pande, P., Monroy, G. L., Reagan, J., Samuelson, J., … Boppart, S. A. (2017). Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification. Lasers in Surgery and Medicine, 49(3), 240–248. https://doi.org/10.1002/lsm.22633 Selmic, L. E., Samuelson, J., Reagan, J. K., Mesa, K. J., Driskell, E., Li, J., … Boppart, S. A. (2018). Intraoperative imaging of surgical margins of canine soft tissue sarcoma using optical coherence tomography. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12448 Holt, D., Singhal, S., & Selmic, L. E. (2019). Near‐infrared imaging and optical coherence tomography for intraoperative visualization of tumors. Veterinary Surgery, 1–11. https://doi.org/10.1111/vsu.13332 |
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Grant Number: 02387-MOU Research Program Area: Neurology |
Hereditary Deafness in Dogs – Genomic Studies in English Setters Using Full Sibling Pairs Kelly-Smith, M., & Strain, G. M. (2020). STRING Data Mining of GWAS Data in Canine Hereditary Pigment-Associated Deafness. Veterinary and Animal Science, 100118. https://doi.org/10.1016/j.vas.2020.100118 Hayward, J. J., Kelly-Smith, M., Boyko, A. R., Burmeister, L., De Risio, L., Mellersh, C., Freeman, J., & Strain, G. M. (2020). A genome-wide association study of deafness in three canine breeds. PLOS ONE, 15(5), e0232900. https://doi.org/10.1371/journal.pone.0232900 |
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Grant Number: 01557 Research Program Area: Oncology |
Narrowing the Search for the Genetic Basis of Histiocytic Malignancies Hédan, B., Rault, M., Abadie, J., Ulvé, R., Botherel, N., Devauchelle, P., Copie‐Bergman, C., Cadieu, E., Parrens, M., Alten, J., Zalcman, E. L., Cario, G., Damaj, G., Mokhtari, K., Loarer, F. L., Coulomb‐Lhermine, A., Derrien, T., Hitte, C., Bachelot, L., … André, C. (2020). PTPN11 mutations in canine and human disseminated histiocytic sarcoma. International Journal of Cancer. https://doi.org/10.1002/ijc.32991 Kennedy, K., Thomas, R., Durrant, J., Jiang, T., Motsinger-Reif, A., & Breen, M. (2019). Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex. Chromosome Research. https://doi.org/10.1007/s10577-019-09606-0 Kennedy, K., Thomas, R., & Breen, M. (2016). Canine Histiocytic Malignancies—Challenges and Opportunities. Veterinary Sciences, 3(1), 2. https://doi.org/10.3390/vetsci3010002 |
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Grant Number: 02446 Research Program Area: Oncology |
Development of Genetic Biomarkers to Improve Diagnosis and Treatment of Canine Histiocytic Sarcoma Hédan, B., Rault, M., Abadie, J., Ulvé, R., Botherel, N., Devauchelle, P., Copie‐Bergman, C., Cadieu, E., Parrens, M., Alten, J., Zalcman, E. L., Cario, G., Damaj, G., Mokhtari, K., Loarer, F. L., Coulomb‐Lhermine, A., Derrien, T., Hitte, C., Bachelot, L., … André, C. (2020). PTPN11 mutations in canine and human disseminated histiocytic sarcoma. International Journal of Cancer. https://doi.org/10.1002/ijc.32991
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Grant Number: 02519 Research Program Area: Oncology - Hemangiosarcoma |
Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas within and between Geographic Locations Lashnits, E., Neupane, P., Bradley, J. M., Richardson, T., Thomas, R., Linder, K. E., Breen, M., Maggi, R. G., & Breitschwerdt, E. B. (2020). Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States. PLOS ONE, 15(1), e0227234. https://doi.org/10.1371/journal.pone.0227234
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Grant Number: 2287 Research Program Area: Tick-Borne Disease Initiative |
Enhanced Testing for the Diagnosis of Bartonellosis in Dogs Neupane, P., Hegarty, B. C., Marr, H. S., Maggi, R. G., Birkenheuer, A. J., & Breitschwerdt, E. B. (2018). Evaluation of cell culture-grown Bartonella antigens in immunofluorescent antibody assays for the serological diagnosis of bartonellosis in dogs. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15301 Neupane, P., Sevala, S., Balakrishnan, N., Marr, H., Wilson, J., Maggi, R., Birkenheuer, A., Lappin, M., Chomel, B., & Breitschwerdt, E. B. (2020). Validation of Bartonella henselae Western Immunoblotting for Serodiagnosis of Bartonelloses in Dogs. Journal of Clinical Microbiology.https://doi.org/10.1128/JCM.01335-19 |
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Grant Number: 01982 Research Program Area: Cardiology |
Personalized Medicine: The Intersection of Genotype and Drug Responsiveness in the Treatment of Canine Pulmonary Hypertension Visser, L. C., Wood, J. E., & Johnson, L. R. (2020). Survival characteristics and prognostic importance of echocardiographic measurements of right heart size and function in dogs with pulmonary hypertension. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15826
Visser, L. C., Im, M. K., Johnson, L. R., & Stern, J. A. (2016). Diagnostic Value of Right Pulmonary Artery Distensibility Index in Dogs with Pulmonary Hypertension: Comparison with Doppler Echocardiographic Estimates of Pulmonary Arterial Pressure. Journal of Veterinary Internal Medicine, 30(2), 543–552. https://doi.org/10.1111/jvim.13911
Ueda, Y., Johnson, L. R., Ontiveros, E. S., Visser, L. C., Gunther-Harrington, C. T., & Stern, J. A. (2019). Effect of a phosphodiesterase-5A ( PDE5A ) gene polymorphism on response to sildenafil therapy in canine pulmonary hypertension. Scientific Reports, 9(1), 6899. https://doi.org/10.1038/s41598-019-43318-z
Johnson, L. R., & Stern, J. A. (2019). Clinical features and outcome in 25 dogs with respiratory-associated pulmonary hypertension treated with sildenafil. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15679
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Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
