Peer-Reviewed Publications Resulting from CHF-funded Grants

We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research.  By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.

You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.

To browse publications by year you may also wish to view our Impact Report.

Research Program Area
Breed:
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Grant Number: 02336

Research Program Area: Ophthalmology

Genetics of Primary Angle Closure Glaucoma in American Cocker Spaniels

Fawver, B. Researchers study genetic causes of glaucoma in Cocker Spaniels. Purina Pro Club. Published online Oct 2017. https://purinaproclub.com/resource-library/pro-club-updates/researchers-study-genetic-causes-of-glaucoma-in-cocker-spaniels/

Park, S, MI Casanova, DL Bannasch, NL Daley, S Kim...S Thomasy. Ocular Morphologic Traits in the American Cocker Spaniel May Confer Primary Angle Closure Glaucoma Susceptibility. (2022, May 18). https://doi.org/10.21203/rs.3.rs-1634088/v1

Grant Number: 02773

Research Program Area: Oncology - Osteosarcoma

Histotripsy for Treatment of Canine Appendicular Osteosarcoma

Hendricks-Wenger, A., Arnold, L., Gannon, J., Simon, A., Singh, N., Sheppard, H., Nagai-Singer, M. A., Imran, K. M., Lee, K., Clark-Deener, S., Byron, C., Edwards, M. R., Larson, M. M., Rossmeisl, J. H., Coutermarsh-Ott, S. L., Eden, K., Dervisis, N., Klahn, S., Tuohy, J., … Vlaisavljevich, E. (2022). Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 69(1), 5–26. https://doi.org/10.1109/TUFFC.2021.3110083

Arnold, L., Hendricks-Wenger, A., Coutermarsh-Ott, S., Gannon, J., Hay, A. N., Dervisis, N., Klahn, S., Allen, I. C., Tuohy, J., & Vlaisavljevich, E. (2021). Histotripsy Ablation of Bone Tumors: Feasibility Study in Excised Canine Osteosarcoma Tumors. Ultrasound in Medicine & Biology. https://doi.org/10.1016/j.ultrasmedbio.2021.08.004

Latifi, M., Hay, A., Carroll, J., Dervisis, N., Arnold, L., Coutermarsh-Ott, S. L., Kierski, K. R., Klahn, S., Allen, I. C., Vlaisavljevich, E., & Tuohy, J. (2021). Focused ultrasound tumour ablation in small animal oncology. Veterinary and Comparative Oncology, 19(3), 411–419. https://doi.org/10.1111/vco.12742

Grant Number: 02604

Research Program Area: Neurology

Clinical, Pathologic, and Molecular Genetics Investigations of Canine Lysosomal Storage Diseases and Related Diseases
Guo, J., Johnson, G. S., Cook, J., Harris, O. K., Mhlanga-Mutangadura, T., Schnabel, R. D., … Katz, M. L. (2019). Neuronal ceroid lipofuscinosis in a German Shorthaired Pointer associated with a previously reported CLN8 nonsense variant. Molecular Genetics and Metabolism Reports, 21, 100521. https://doi.org/10.1016/j.ymgmr.2019.100521

Bullock, G., Johnson, G. S., Mhlanga-Mutangadura, T., Petesch, S. C., Thompson, S., Goebbels, S., & Katz, M. L. (2022). Lysosomal Storage Disease Associated with a CNP Sequence Variant in Dalmatian Dogs. Gene, 146513. https://doi.org/10.1016/j.gene.2022.146513

Grant Number: 02661

Research Program Area: Cardiology

Investigation into Diet-Associated Dilated Cardiomyopathy in Dogs

Adin, D., Freeman, L., Stepien, R., Rush, J. E., Tjostheim, S., Kellihan, H., Aherne, M., Vereb, M., & Goldberg, R. (2021). Effect of type of diet on blood and plasma taurine concentrations, cardiac biomarkers, and echocardiograms in 4 dog breeds. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16075

Haimovitz, D., Vereb, M., Freeman, L., Goldberg, R., Lessard, D., Rush, J., & Adin, D. (2022). Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16416

Grant Number: 02383

Research Program Area: Tick-Borne Disease Initiative

Identifying Cellular Mechanisms of Inflammation During Canine Tick‐Borne Diseases

Scorza, B. M., Mahachi, K. G., Cox, A. D., Toepp, A. J., Pessoa-Pereira, D., Tyrrell, P., Buch, J., Foltz, J. A., Lee, D., & Petersen, C. A. (2022). Role of NK-Like CD8+ T Cells during Asymptomatic Borrelia burgdorferi Infection. Infection and Immunity, 0(0), e00555-21. https://doi.org/10.1128/iai.00555-21

Grant Number: 02234-MOU

Research Program Area: Oncology - Hemangiosarcoma

A Novel Approach for Prevention of Canine Hemangiosarcoma

Sarver, A. L., Makielski, K. M., DePauw, T. A., Schulte, A. J., & Modiano, J. F. (2022). Increased risk of cancer in dogs and humans: A consequence of recent extension of lifespan beyond evolutionarily determined limitations? Aging and Cancer. https://doi.org/10.1002/aac2.12046

Borgatti, A., Fieberg, A., Winter, A. L., Stuebner, K., Taras, E., Todhunter, D., Masyr, A., Rendhal, A., Vallera, D. A., Koopmeiners, J. S., & Modiano, J. F. (2020). Impact of Repeated Cycles of EGF Bispecific Angiotoxin (eBAT) Administered at a Reduced Interval from Doxorubicin Chemotherapy in Dogs with Splenic Hemangiosarcoma. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12590

Grant Number: 02709

Research Program Area: Gastrointestinal Disease

Identification of Genetic Risk Factors Contributing to Gastrointestinal Motility Disorders

Bell, S. M., Evans, J. M., Evans, K. M., Tsai, K. L., Noorai, R. E., Famula, T. R., Holle, D. M., & Clark, L. A. (2022). Congenital idiopathic megaesophagus in the German shepherd dog is a sex-differentiated trait and is associated with an intronic variable number tandem repeat in Melanin-Concentrating Hormone Receptor 2. PLOS Genetics, 18(3), e1010044. https://doi.org/10.1371/journal.pgen.1010044

Grant Number: 02052

Research Program Area: Immunology and Infectious Disease

Defining the Mechanism of Severe, Life-Threatening Bleeding Disorders in Dogs

Brooks, M. B., Maruyama, H., Cremer, S. E., Goggs, R., Forman, M. A., Koch, M., Merriam, J., Makielski, K., Viall, A., & LeVine, D. N. (2022). Preliminary evaluation of a flow cytometric assay with microsphere controls for the detection of platelet-bound antibodies in canine immune thrombocytopenia. Veterinary Clinical Pathology. https://doi.org/10.1111/vcp.13093

Makielski, K. M., Brooks, M. B., Wang, C., Cullen, J. N., O’Connor, A. M., & LeVine, D. N. (2018). Development and implementation of a novel immune thrombocytopenia bleeding score for dogs. Journal of Veterinary Internal Medicine, 32(3), 1041–1050. https://doi.org/10.1111/jvim.15089

Grant Number: 02806-MOU

Research Program Area: Oncology - Hemangiosarcoma

Strategic Prevention of Canine Hemangiosarcoma: Lifetime Follow-Up

Sarver, A. L., Makielski, K. M., DePauw, T. A., Schulte, A. J., & Modiano, J. F. (2022). Increased risk of cancer in dogs and humans: A consequence of recent extension of lifespan beyond evolutionarily determined limitations? Aging and Cancer. https://doi.org/10.1002/aac2.12046

Grant Number: 02536-MOU

Research Program Area: Blood Disorders

Immunoprofiling to Combat Canine Immune Thrombocytopenia

Brooks, M. B., Maruyama, H., Cremer, S. E., Goggs, R., Forman, M. A., Koch, M., Merriam, J., Makielski, K., Viall, A., & LeVine, D. N. (2022). Preliminary evaluation of a flow cytometric assay with microsphere controls for the detection of platelet-bound antibodies in canine immune thrombocytopenia. Veterinary Clinical Pathology. https://doi.org/10.1111/vcp.13093

Grant Number: 02653-A

Research Program Area: Dermatology and Allergic Disease

Evaluation of the Serum and Cutaneous Levels of Chemokines in Atopic Dogs

Santoro, D., Archer, L., & Chong, E. (2022). Evaluation of cutaneous and circulating (serum and exosomes) levels of chemokines (CCL17, CCL22, CCL27 and CCL28) in atopic dogs and their correlation with severity of the disease. Veterinary Dermatology. https://doi.org/10.1111/vde.13061

Grant Number: 02838

Research Program Area: Immunology and Infectious Disease

Standardization of rLiNTPDase2 and Derived Chimeras as Antigens on Immunochromatographic Assay for Diagnosis of Canine Visceral Leishmaniasis

de Castro, R. B., de Souza, A. C. A., Pavione, N. da R. T., de Moraes, J. V. B., Ribeiro, I. C., de Melo Agripino, J., Bressan, G. C., de Souza Vasconcellos, R., Silva-Júnior, A., & Fietto, J. L. R. (2022). Urea, salts, and Tween 20 influence on adsorption of IgG and Leishmania rNTPDase2 to nitrocellulose. Analytical Biochemistry, 114648. https://doi.org/10.1016/j.ab.2022.114648

Grant Number: 02407-A

Research Program Area: Immunology and Infectious Disease

In vitro Efficacy of Nano-sulfur Against Planktonic and Biofilm State of Resistant Bacteria

Kher, L., Santoro, D., Kelley, K., Gibson, D., & Schultz, G. (2022). Effect of Nanosulfur Against Multidrug-Resistant Staphylococcus pseudintermedius and Pseudomonas aeruginosa. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-022-11872-8

Grant Number: 02519

Research Program Area: Tick-Borne Disease Initiative , Oncology - Hemangiosarcoma

Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas within and between Geographic Locations

Lashnits, E., Neupane, P., Bradley, J. M., Richardson, T., Maggi, R. G., & Breitschwerdt, E. B. (2021). Comparison of Serological and Molecular Assays for Bartonella Species in Dogs with Hemangiosarcoma. Pathogens, 10(7), 794. https://doi.org/10.3390/pathogens10070794

Lashnits, E., Neupane, P., Bradley, J. M., Richardson, T., Thomas, R., Linder, K. E., Breen, M., Maggi, R. G., & Breitschwerdt, E. B. (2020). Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States. PLOS ONE, 15(1), e0227234. https://doi.org/10.1371/journal.pone.0227234

Maggi, R. G., Richardson, T., Breitschwerdt, E. B., & Miller, J. C. (2020). Development and validation of a droplet digital PCR assay for the detection and quantification of Bartonella species within human clinical samples. Journal of Microbiological Methods, 176, 106022. https://doi.org/10.1016/j.mimet.2020.106022

Neupane, P., Sevala, S., Balakrishnan, N., Marr, H., Wilson, J., Maggi, R., Birkenheuer, A., Lappin, M., Chomel, B., & Breitschwerdt, E. B. (2020). Validation of Bartonella henselae Western Immunoblotting for Serodiagnosis of Bartonelloses in Dogs. Journal of Clinical Microbiology. https://doi.org/10.1128/JCM.01335-19

Grant Number: 02502

Research Program Area: Oncology - Lymphoma

Precision Medicine for Canine Lymphoma

Wang, G., Wu, M., Durham, A. C., Mason, N. J., & Roth, D. B. (2021). Canine Oncopanel: A capture-based, NGS platform for evaluating the mutational landscape and detecting putative driver mutations in canine cancers. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12746

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