Peer-Reviewed Publications Resulting from CHF-funded Grants

We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research.  By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.

You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.

To browse publications by year you may also wish to view our Impact Report.

Research Program Area
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Grant Number: 02661

Research Program Area: Cardiology

Investigation into Diet-Associated Dilated Cardiomyopathy in Dogs

Adin, D., Freeman, L., Stepien, R., Rush, J. E., Tjostheim, S., Kellihan, H., Aherne, M., Vereb, M., & Goldberg, R. (2021). Effect of type of diet on blood and plasma taurine concentrations, cardiac biomarkers, and echocardiograms in 4 dog breeds. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16075

Haimovitz, D., Vereb, M., Freeman, L., Goldberg, R., Lessard, D., Rush, J., & Adin, D. (2022). Effect of diet change in healthy dogs with subclinical cardiac biomarker or echocardiographic abnormalities. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16416

Adin, D. B., Haimovitz, D., Freeman, L. M., & Rush, J. E. (2022). Untargeted global metabolomic profiling of healthy dogs grouped on the basis of grain inclusivity of their diet and of dogs with subclinical cardiac abnormalities that underwent a diet change. American Journal of Veterinary Research, 83(9). https://doi.org/10.2460/ajvr.22.03.0054

Grant Number: 02855-A

Research Program Area: Oncology

Repurposing Drugs to Modulate Myeloid-derived Suppressor Cells (MDSCs) in Canine Soft Tissue Sarcomas

Soileau, A. M., Quick, C. N., Moeller, C. E., Schaumburg, J. C., & Withers, S. S. (2022). The Effect of Arginase on Canine T-Lymphocyte Functions and its Modulation by All-Trans Retinoid Acid (ATRA) in Canine Monocyte-Derived Macrophages. Veterinary Sciences, 9(7), 374. https://doi.org/10.3390/vetsci9070374

Grant Number: 02536-MOU

Research Program Area: Blood Disorders

Immunoprofiling to Combat Canine Immune Thrombocytopenia

Brooks, M. B., Maruyama, H., Cremer, S. E., Goggs, R., Forman, M. A., Koch, M., Merriam, J., Makielski, K., Viall, A., & LeVine, D. N. (2022). Preliminary evaluation of a flow cytometric assay with microsphere controls for the detection of platelet-bound antibodies in canine immune thrombocytopenia. Veterinary Clinical Pathology. https://doi.org/10.1111/vcp.13093

Grant Number: 2614

Research Program Area: Epilepsy Initiative

Refining the Genetic Linkage For Idiopathic Epilepsy in the Belgian Tervuren and Sheepdog

Belanger, J. M., Heinonen, T., Famula, T. R., Mandigers, P. J. J., Leegwater, P. A., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2022). Validation of a Chromosome 14 Risk Haplotype for Idiopathic Epilepsy in the Belgian Shepherd Dog Found to Be Associated with an Insertion in the RAPGEF5 Gene. Genes, 13(7), 1124. https://doi.org/10.3390/genes13071124

Belanger, J. M., Famula, T. R., Gershony, L. C., Palij, M. K., & Oberbauer, A. M. (2020). Genome-wide association analysis of idiopathic epilepsy in the Belgian Shepherd. Canine Medicine and Genetics, 7(1), 12. https://doi.org/10.1186/s40575-020-00091-x

Oberbauer, A. M., Belanger, J. M., Grossman, D. I., Regan, K. R., & Famula, T. R. (2010). Genome-wide linkage scan for loci associated with epilepsy in Belgian Shepherd Dogs. BMC Genetics, 11, 35. https://doi.org/10.1186/1471-2156-11-35

>Seppälä, E. H., Koskinen, L. L. E., Gulløv, C. H., Jokinen, P., Karlskov-Mortensen, P., Bergamasco, L., … Lohi, H. (2012). Identification of a Novel Idiopathic Epilepsy Locus in Belgian Shepherd Dogs. PLoS ONE, 7(3), e33549. https://doi.org/10.1371/journal.pone.0033549

Grant Number: 02758

Research Program Area: Oncology

Optical Coherence Tomography for Margin Evaluation of Canine Skin and Subcutaneous Neoplasms

Cheng, E., Jennings, R. N., Chen, C. L., Biggo, M. R., Erickson, A. K., Dornbusch, J. A., Linn, S. C., Lapsley, J., Alva, B. M., Lorbach, J. N., Premanandan, C., & Selmic, L. E. (2022). Optical coherence tomography for surgical margin evaluation of excised canine cutaneous and subcutaneous tumors. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12844

Grant Number: 02336

Research Program Area: Ophthalmology

Genetics of Primary Angle Closure Glaucoma in American Cocker Spaniels

Fawver, B. Researchers study genetic causes of glaucoma in Cocker Spaniels. Purina Pro Club. Published online Oct 2017. https://purinaproclub.com/resource-library/pro-club-updates/researchers-study-genetic-causes-of-glaucoma-in-cocker-spaniels/

Park, S, MI Casanova, DL Bannasch, NL Daley, S Kim...S Thomasy. Ocular Morphologic Traits in the American Cocker Spaniel May Confer Primary Angle Closure Glaucoma Susceptibility. (2022, May 18). https://doi.org/10.21203/rs.3.rs-1634088/v1

Gomes, F. E., Casanova, M. I., Mouttham, L., Bannasch, D. L., Park, S., Kim, S., Young, L. J., Daley, N. L., Thomasy, S. M., Castelhano, M. G., Ledbetter, E. C., Holmberg, B., Boyd, R., Woerdt, A. V. D., McDonald, J., & Hayward, J. J. (2022). A genome-wide association study to investigate genetic loci associated with primary glaucoma in American Cocker Spaniels. American Journal of Veterinary Research, 1(aop), 1–8. https://doi.org/10.2460/ajvr.22.07.0106

Grant Number: 02383

Research Program Area: Tick-Borne Disease Initiative

Identifying Cellular Mechanisms of Inflammation During Canine Tick‐Borne Diseases

Scorza, B. M., Mahachi, K. G., Cox, A. D., Toepp, A. J., Pessoa-Pereira, D., Tyrrell, P., Buch, J., Foltz, J. A., Lee, D., & Petersen, C. A. (2022). Role of NK-Like CD8+ T Cells during Asymptomatic Borrelia burgdorferi Infection. Infection and Immunity, 0(0), e00555-21. https://doi.org/10.1128/iai.00555-21

Grant Number: 02234-MOU

Research Program Area: Oncology - Hemangiosarcoma

A Novel Approach for Prevention of Canine Hemangiosarcoma

Sarver, A. L., Makielski, K. M., DePauw, T. A., Schulte, A. J., & Modiano, J. F. (2022). Increased risk of cancer in dogs and humans: A consequence of recent extension of lifespan beyond evolutionarily determined limitations? Aging and Cancer. https://doi.org/10.1002/aac2.12046

Borgatti, A., Fieberg, A., Winter, A. L., Stuebner, K., Taras, E., Todhunter, D., Masyr, A., Rendhal, A., Vallera, D. A., Koopmeiners, J. S., & Modiano, J. F. (2020). Impact of Repeated Cycles of EGF Bispecific Angiotoxin (eBAT) Administered at a Reduced Interval from Doxorubicin Chemotherapy in Dogs with Splenic Hemangiosarcoma. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12590

Grant Number: 02285-A

Research Program Area: Tick-Borne Disease Initiative

Thrombocytopenia and Occult Vector-Borne Disease in Greyhound Dogs: Implications for Clinical Cases and Blood Donors

Kidd, L., Hamilton, H., Stine, L., Qurollo, B., & Breitschwerdt, E. B. (2022). Vector-borne disease and its relationship to hematologic abnormalities and microalbuminuria in retired racing and show-bred greyhounds. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16477

Grant Number: 02773

Research Program Area: Oncology - Osteosarcoma

Histotripsy for Treatment of Canine Appendicular Osteosarcoma

Ruger, L. N., Hay, A. N., Gannon, J. M., Sheppard, H. O., Coutermarsh-Ott, S. L., Daniel, G. B., Kierski, K. R., Ciepluch, B. J., Vlaisavljevich, E., & Tuohy, J. L. (2022). Histotripsy Ablation of Spontaneously Occurring Canine Bone Tumors In Vivo. IEEE Transactions on Biomedical Engineering, 1–12. https://doi.org/10.1109/TBME.2022.3191069

Hendricks-Wenger, A., Arnold, L., Gannon, J., Simon, A., Singh, N., Sheppard, H., Nagai-Singer, M. A., Imran, K. M., Lee, K., Clark-Deener, S., Byron, C., Edwards, M. R., Larson, M. M., Rossmeisl, J. H., Coutermarsh-Ott, S. L., Eden, K., Dervisis, N., Klahn, S., Tuohy, J., … Vlaisavljevich, E. (2022). Histotripsy Ablation in Preclinical Animal Models of Cancer and Spontaneous Tumors in Veterinary Patients: A Review. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 69(1), 5–26. https://doi.org/10.1109/TUFFC.2021.3110083

Arnold, L., Hendricks-Wenger, A., Coutermarsh-Ott, S., Gannon, J., Hay, A. N., Dervisis, N., Klahn, S., Allen, I. C., Tuohy, J., & Vlaisavljevich, E. (2021). Histotripsy Ablation of Bone Tumors: Feasibility Study in Excised Canine Osteosarcoma Tumors. Ultrasound in Medicine & Biology. https://doi.org/10.1016/j.ultrasmedbio.2021.08.004

Latifi, M., Hay, A., Carroll, J., Dervisis, N., Arnold, L., Coutermarsh-Ott, S. L., Kierski, K. R., Klahn, S., Allen, I. C., Vlaisavljevich, E., & Tuohy, J. (2021). Focused ultrasound tumour ablation in small animal oncology. Veterinary and Comparative Oncology, 19(3), 411–419. https://doi.org/10.1111/vco.12742

Grant Number: 02407-A

Research Program Area: Immunology and Infectious Disease

In vitro Efficacy of Nano-sulfur Against Planktonic and Biofilm State of Resistant Bacteria

Kher, L., Santoro, D., Kelley, K., Gibson, D., & Schultz, G. (2022). Effect of Nanosulfur Against Multidrug-Resistant Staphylococcus pseudintermedius and Pseudomonas aeruginosa. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-022-11872-8

Grant Number: 2015

Research Program Area: Epilepsy Initiative

Development of a Genetic Marker for Idiopathic Epilepsy in the Belgian Tervuren and Belgian Sheepdog

Belanger, J. M., Heinonen, T., Famula, T. R., Mandigers, P. J. J., Leegwater, P. A., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2022). Validation of a Chromosome 14 Risk Haplotype for Idiopathic Epilepsy in the Belgian Shepherd Dog Found to Be Associated with an Insertion in the RAPGEF5 Gene. Genes, 13(7), 1124. https://doi.org/10.3390/genes13071124

Belanger, J. M., Famula, T. R., Gershony, L. C., Palij, M. K., & Oberbauer, A. M. (2020). Genome-wide association analysis of idiopathic epilepsy in the Belgian Shepherd. Canine Medicine and Genetics, 7(1), 12. https://doi.org/10.1186/s40575-020-00091-x

Oberbauer, A. M. (2003). The Genetics of Epilepsy in the Belgian Tervuren and Sheepdog. Journal of Heredity, 94(1), 57–63. https://doi.org/10.1093/jhered/esg010

Oberbauer, Anita M., Belanger, J. M., Grossman, D. I., Regan, K. R., & Famula, T. R. (2010). Genome-wide linkage scan for loci associated with epilepsy in Belgian Shepherd Dogs. BMC Genetics, 11, 35. https://doi.org/10.1186/1471-2156-11-35

Grant Number: 01918-G

Research Program Area: Oncology - Lymphoma

Discovery of Biomarkers to Detect Lymphoma Risk, Classify For Treatment, and Predict Outcome in Golden Retrievers

Chu, S., Avery, A., Yoshimoto, J., & Bryan, J. N. (2022). Genome wide exploration of the methylome in aggressive B-cell lymphoma in Golden Retrievers reveals a conserved hypermethylome. Epigenetics, 0(0), 1–17. https://doi.org/10.1080/15592294.2022.2105033

Grant Number: 1771

Research Program Area: Immunology and Infectious Disease

Defining the Unique Genetic Markers in Dogs That Define Immune Function, Disease Resistance and Tissue Transplantation

Pyo, C.-W., Harkey, M. A., Torok-Storb, B., Storb, R., Wang, R., Thomas, A. S., Nelson, W. C., & Geraghty, D. E. (2022). Genotyping of canine MHC gene DLA-88 by next-generation sequencing reveals high frequencies of new allele discovery and gene duplication. HLA. https://doi.org/10.1111/tan.14752

Harkey, M. A., Villagran, A. M., Venkataraman, G. M., Leisenring, W. M., Hullar, M. A. J., & Torok-Storb, B. J. (2017). Associations between gastric dilatation-volvulus in Great Danes and specific alleles of canine immune-system genes DLA88, DRB1, and TLR5. American Journal of Veterinary Research, 78(8), 12.

Hullar, M. A. J., Lampe, J. W., Torok-Storb, B. J., & Harkey, M. A. (2018). The canine gut microbiome is associated with higher risk of gastric dilatation-volvulus and high risk genetic variants of the immune system. PLOS ONE, 13(6), e0197686. https://doi.org/10.1371/journal.pone.0197686

Tsai, K. L., Starr-Moss, A. N., Venkataraman, G. M., Robinson, C., Kennedy, L. J., Steiner, J. M., & Clark, L. A. (2013). Alleles of the major histocompatibility complex play a role in the pathogenesis of pancreatic acinar atrophy in dogs. Immunogenetics, 65(7), 501–509. https://doi.org/10.1007/s00251-013-0704-y

Venkataraman, G. M., Geraghty, D., Fox, J., Graves, S. S., Zellmer, E., Storer, B. E., … Storb, R. (2013). Canine DLA-79 gene: an improved typing method, identification of new alleles and its role in graft rejection and graft-versus-host disease. Tissue Antigens, 81(4), 204–211. https://doi.org/10.1111/tan.12094

Venkataraman, G. M., Kennedy, L. J., Little, M.-T. E., Graves, S. S., Harkey, M. A., Torok-Storb, B. J., & Storb, R. (2017). Thirteen novel canine dog leukocyte antigen-88 alleles identified by sequence-based typing. HLA, 90(3), 165–170. https://doi.org/10.1111/tan.13077

Grant Number: 02709

Research Program Area: Gastrointestinal Disease

Identification of Genetic Risk Factors Contributing to Gastrointestinal Motility Disorders

Bell, S. M., Evans, J. M., Evans, K. M., Tsai, K. L., Noorai, R. E., Famula, T. R., Holle, D. M., & Clark, L. A. (2022). Congenital idiopathic megaesophagus in the German shepherd dog is a sex-differentiated trait and is associated with an intronic variable number tandem repeat in Melanin-Concentrating Hormone Receptor 2. PLOS Genetics, 18(3), e1010044. https://doi.org/10.1371/journal.pgen.1010044

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