Peer-Reviewed Publications Resulting from CHF-funded Grants

We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research.  By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.

You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.

To browse publications by year you may also wish to view our Impact Report.

Research Program Area
Breed:
Disease:
 
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Grant Number: 02404-A

Research Program Area: Immunology and Infectious Disease

The Impact of Lidocaine Administration on Natural Killer Cell Populations in Canine Sepsis

None at this time.

Grant Number: 2336

Research Program Area: Ophthalmology

Genetics of Primary Angle Closure Glaucoma in American Cocker Spaniels

None at this time.

Grant Number: 02768

Research Program Area: Oncology - Osteosarcoma

Defining the Functional Consequences and Therapeutic Vulnerability of Dystrophin Alterations in Canine Osteosarcoma

Megquier, K., Turner-Maier, J., Morrill, K., Li, X., Johnson, J., Karlsson, E. K., London, C. A., & Gardner, H. L. (2022). The genomic landscape of canine osteosarcoma cell lines reveals conserved structural complexity and pathway alterations. PLOS ONE, 17(9), e0274383. https://doi.org/10.1371/journal.pone.0274383

Grant Number: 02653-A

Research Program Area: Dermatology and Allergic Disease

Evaluation of the Serum and Cutaneous Levels of Chemokines in Atopic Dogs

Santoro, D., Archer, L., & Chong, E. (2022). Evaluation of cutaneous and circulating (serum and exosomes) levels of chemokines (CCL17, CCL22, CCL27 and CCL28) in atopic dogs and their correlation with severity of the disease. Veterinary Dermatology. https://doi.org/10.1111/vde.13061

Grant Number: 2614

Research Program Area: Epilepsy Initiative

Refining the Genetic Linkage For Idiopathic Epilepsy in the Belgian Tervuren and Sheepdog

Belanger, J. M., Heinonen, T., Famula, T. R., Mandigers, P. J. J., Leegwater, P. A., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2022). Validation of a Chromosome 14 Risk Haplotype for Idiopathic Epilepsy in the Belgian Shepherd Dog Found to Be Associated with an Insertion in the RAPGEF5 Gene. Genes, 13(7), 1124. https://doi.org/10.3390/genes13071124

Belanger, J. M., Famula, T. R., Gershony, L. C., Palij, M. K., & Oberbauer, A. M. (2020). Genome-wide association analysis of idiopathic epilepsy in the Belgian Shepherd. Canine Medicine and Genetics, 7(1), 12. https://doi.org/10.1186/s40575-020-00091-x

Oberbauer, A. M., Belanger, J. M., Grossman, D. I., Regan, K. R., & Famula, T. R. (2010). Genome-wide linkage scan for loci associated with epilepsy in Belgian Shepherd Dogs. BMC Genetics, 11, 35. https://doi.org/10.1186/1471-2156-11-35

>Seppälä, E. H., Koskinen, L. L. E., Gulløv, C. H., Jokinen, P., Karlskov-Mortensen, P., Bergamasco, L., … Lohi, H. (2012). Identification of a Novel Idiopathic Epilepsy Locus in Belgian Shepherd Dogs. PLoS ONE, 7(3), e33549. https://doi.org/10.1371/journal.pone.0033549

Grant Number: 02285-A

Research Program Area: Tick-Borne Disease Initiative

Thrombocytopenia and Occult Vector-Borne Disease in Greyhound Dogs: Implications for Clinical Cases and Blood Donors

Kidd, L., Hamilton, H., Stine, L., Qurollo, B., & Breitschwerdt, E. B. (2022). Vector-borne disease and its relationship to hematologic abnormalities and microalbuminuria in retired racing and show-bred greyhounds. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16477

Grant Number: 02407-A

Research Program Area: Immunology and Infectious Disease

In vitro Efficacy of Nano-sulfur Against Planktonic and Biofilm State of Resistant Bacteria

Kher, L., Santoro, D., Kelley, K., Gibson, D., & Schultz, G. (2022). Effect of Nanosulfur Against Multidrug-Resistant Staphylococcus pseudintermedius and Pseudomonas aeruginosa. Applied Microbiology and Biotechnology. https://doi.org/10.1007/s00253-022-11872-8

Grant Number: 2015

Research Program Area: Epilepsy Initiative

Development of a Genetic Marker for Idiopathic Epilepsy in the Belgian Tervuren and Belgian Sheepdog

Belanger, J. M., Heinonen, T., Famula, T. R., Mandigers, P. J. J., Leegwater, P. A., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2022). Validation of a Chromosome 14 Risk Haplotype for Idiopathic Epilepsy in the Belgian Shepherd Dog Found to Be Associated with an Insertion in the RAPGEF5 Gene. Genes, 13(7), 1124. https://doi.org/10.3390/genes13071124

Belanger, J. M., Famula, T. R., Gershony, L. C., Palij, M. K., & Oberbauer, A. M. (2020). Genome-wide association analysis of idiopathic epilepsy in the Belgian Shepherd. Canine Medicine and Genetics, 7(1), 12. https://doi.org/10.1186/s40575-020-00091-x

Oberbauer, A. M. (2003). The Genetics of Epilepsy in the Belgian Tervuren and Sheepdog. Journal of Heredity, 94(1), 57–63. https://doi.org/10.1093/jhered/esg010

Oberbauer, Anita M., Belanger, J. M., Grossman, D. I., Regan, K. R., & Famula, T. R. (2010). Genome-wide linkage scan for loci associated with epilepsy in Belgian Shepherd Dogs. BMC Genetics, 11, 35. https://doi.org/10.1186/1471-2156-11-35

Grant Number: 02758

Research Program Area: Oncology

Optical Coherence Tomography for Margin Evaluation of Canine Skin and Subcutaneous Neoplasms

Cheng, E., Jennings, R. N., Chen, C. L., Biggo, M. R., Erickson, A. K., Dornbusch, J. A., Linn, S. C., Lapsley, J., Alva, B. M., Lorbach, J. N., Premanandan, C., & Selmic, L. E. (2022). Optical coherence tomography for surgical margin evaluation of excised canine cutaneous and subcutaneous tumors. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12844

Grant Number: 01918-G

Research Program Area: Oncology - Lymphoma

Discovery of Biomarkers to Detect Lymphoma Risk, Classify For Treatment, and Predict Outcome in Golden Retrievers

Chu, S., Avery, A., Yoshimoto, J., & Bryan, J. N. (2022). Genome wide exploration of the methylome in aggressive B-cell lymphoma in Golden Retrievers reveals a conserved hypermethylome. Epigenetics, 0(0), 1–17. https://doi.org/10.1080/15592294.2022.2105033

Grant Number: 1771

Research Program Area: Immunology and Infectious Disease

Defining the Unique Genetic Markers in Dogs That Define Immune Function, Disease Resistance and Tissue Transplantation

Pyo, C.-W., Harkey, M. A., Torok-Storb, B., Storb, R., Wang, R., Thomas, A. S., Nelson, W. C., & Geraghty, D. E. (2022). Genotyping of canine MHC gene DLA-88 by next-generation sequencing reveals high frequencies of new allele discovery and gene duplication. HLA. https://doi.org/10.1111/tan.14752

Harkey, M. A., Villagran, A. M., Venkataraman, G. M., Leisenring, W. M., Hullar, M. A. J., & Torok-Storb, B. J. (2017). Associations between gastric dilatation-volvulus in Great Danes and specific alleles of canine immune-system genes DLA88, DRB1, and TLR5. American Journal of Veterinary Research, 78(8), 12.

Hullar, M. A. J., Lampe, J. W., Torok-Storb, B. J., & Harkey, M. A. (2018). The canine gut microbiome is associated with higher risk of gastric dilatation-volvulus and high risk genetic variants of the immune system. PLOS ONE, 13(6), e0197686. https://doi.org/10.1371/journal.pone.0197686

Tsai, K. L., Starr-Moss, A. N., Venkataraman, G. M., Robinson, C., Kennedy, L. J., Steiner, J. M., & Clark, L. A. (2013). Alleles of the major histocompatibility complex play a role in the pathogenesis of pancreatic acinar atrophy in dogs. Immunogenetics, 65(7), 501–509. https://doi.org/10.1007/s00251-013-0704-y

Venkataraman, G. M., Geraghty, D., Fox, J., Graves, S. S., Zellmer, E., Storer, B. E., … Storb, R. (2013). Canine DLA-79 gene: an improved typing method, identification of new alleles and its role in graft rejection and graft-versus-host disease. Tissue Antigens, 81(4), 204–211. https://doi.org/10.1111/tan.12094

Venkataraman, G. M., Kennedy, L. J., Little, M.-T. E., Graves, S. S., Harkey, M. A., Torok-Storb, B. J., & Storb, R. (2017). Thirteen novel canine dog leukocyte antigen-88 alleles identified by sequence-based typing. HLA, 90(3), 165–170. https://doi.org/10.1111/tan.13077

Grant Number: 02234-MOU

Research Program Area: Oncology - Hemangiosarcoma

A Novel Approach for Prevention of Canine Hemangiosarcoma

Sarver, A. L., Makielski, K. M., DePauw, T. A., Schulte, A. J., & Modiano, J. F. (2022). Increased risk of cancer in dogs and humans: A consequence of recent extension of lifespan beyond evolutionarily determined limitations? Aging and Cancer. https://doi.org/10.1002/aac2.12046

Borgatti, A., Fieberg, A., Winter, A. L., Stuebner, K., Taras, E., Todhunter, D., Masyr, A., Rendhal, A., Vallera, D. A., Koopmeiners, J. S., & Modiano, J. F. (2020). Impact of Repeated Cycles of EGF Bispecific Angiotoxin (eBAT) Administered at a Reduced Interval from Doxorubicin Chemotherapy in Dogs with Splenic Hemangiosarcoma. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12590

Grant Number: 02669-A

Research Program Area: Reproductive Conditions

Lipid Composition and Lipid Droplet Dynamics in Canine Pyometra Affected Endometria

Leitner, N., Hlavaty, J., Heider, S., Ertl, R., Gabriel, C., & Walter, I. (2022). Lipid droplet dynamics in healthy and pyometra-affected canine endometrium. BMC Veterinary Research, 18(1), 221. https://doi.org/10.1186/s12917-022-03321-5

Grant Number: 02157-MOU

Research Program Area: Neurology

Genomics of Deafness in the Dalmatian

Haase, B., Willet, C. E., Chew, T., Samaha, G., Child, G., & Wade, C. M. (2022). De-novo and genome-wide meta-analyses identify a risk haplotype for congenital sensorineural deafness in Dalmatian dogs. Scientific Reports, 12(1), 15439. https://doi.org/10.1038/s41598-022-19535-4

Brancalion, L., Haase, B., Mazrier, H., Willet, C. E., Lindblad‐Toh, K., Lingaas, F., & Wade, C. M. (2021). Roan, ticked and clear coat patterns in the canine are associated with three haplotypes near usherin on CFA38. Animal Genetics. https://doi.org/10.1111/age.13040

Brancalion, L., Haase, B., Willet, C. E., & Wade, C. M. (2021). Sequence variants of the canine melanocyte inducing transcription factor (MITF) locus reveal a common MITF-A processed pseudogene. Animal Genetics, 52(5), 777–778. https://doi.org/10.1111/age.13106

Grant Number: 02052

Research Program Area: Immunology and Infectious Disease

Defining the Mechanism of Severe, Life-Threatening Bleeding Disorders in Dogs

Brooks, M. B., Maruyama, H., Cremer, S. E., Goggs, R., Forman, M. A., Koch, M., Merriam, J., Makielski, K., Viall, A., & LeVine, D. N. (2022). Preliminary evaluation of a flow cytometric assay with microsphere controls for the detection of platelet-bound antibodies in canine immune thrombocytopenia. Veterinary Clinical Pathology. https://doi.org/10.1111/vcp.13093

Makielski, K. M., Brooks, M. B., Wang, C., Cullen, J. N., O’Connor, A. M., & LeVine, D. N. (2018). Development and implementation of a novel immune thrombocytopenia bleeding score for dogs. Journal of Veterinary Internal Medicine, 32(3), 1041–1050. https://doi.org/10.1111/jvim.15089

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