Peer-Reviewed Publications Resulting from CHF-funded Grants

We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research.  By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.

You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.

To browse publications by year you may also wish to view our Impact Report.

Research Program Area
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Grant Number: 02553

Research Program Area: Tick-Borne Disease Initiative

Targeted Next Generation Sequencing Panel for Comprehensive Testing of Vector-borne Pathogens

Kattoor, J. J., Nikolai, E., Qurollo, B., & Wilkes, R. P. (2022). Targeted Next-Generation Sequencing for Comprehensive Testing for Selected Vector-Borne Pathogens in Canines. Pathogens, 11(9), 964. https://doi.org/10.3390/pathogens11090964

Grant Number: 2614

Research Program Area: Epilepsy Initiative

Refining the Genetic Linkage For Idiopathic Epilepsy in the Belgian Tervuren and Sheepdog

Belanger, J. M., Heinonen, T., Famula, T. R., Mandigers, P. J. J., Leegwater, P. A., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2022). Validation of a Chromosome 14 Risk Haplotype for Idiopathic Epilepsy in the Belgian Shepherd Dog Found to Be Associated with an Insertion in the RAPGEF5 Gene. Genes, 13(7), 1124. https://doi.org/10.3390/genes13071124

Belanger, J. M., Famula, T. R., Gershony, L. C., Palij, M. K., & Oberbauer, A. M. (2020). Genome-wide association analysis of idiopathic epilepsy in the Belgian Shepherd. Canine Medicine and Genetics, 7(1), 12. https://doi.org/10.1186/s40575-020-00091-x

Oberbauer, A. M., Belanger, J. M., Grossman, D. I., Regan, K. R., & Famula, T. R. (2010). Genome-wide linkage scan for loci associated with epilepsy in Belgian Shepherd Dogs. BMC Genetics, 11, 35. https://doi.org/10.1186/1471-2156-11-35

>Seppälä, E. H., Koskinen, L. L. E., Gulløv, C. H., Jokinen, P., Karlskov-Mortensen, P., Bergamasco, L., … Lohi, H. (2012). Identification of a Novel Idiopathic Epilepsy Locus in Belgian Shepherd Dogs. PLoS ONE, 7(3), e33549. https://doi.org/10.1371/journal.pone.0033549

Grant Number: 02838

Research Program Area: Immunology and Infectious Disease

Standardization of rLiNTPDase2 and Derived Chimeras as Antigens on Immunochromatographic Assay for Diagnosis of Canine Visceral Leishmaniasis

de Castro, R. B., de Souza, A. C. A., Pavione, N. da R. T., de Moraes, J. V. B., Ribeiro, I. C., de Melo Agripino, J., Bressan, G. C., de Souza Vasconcellos, R., Silva-Júnior, A., & Fietto, J. L. R. (2022). Urea, salts, and Tween 20 influence on adsorption of IgG and Leishmania rNTPDase2 to nitrocellulose. Analytical Biochemistry, 114648. https://doi.org/10.1016/j.ab.2022.114648

Grant Number: 02452-A

Research Program Area: Neurology

Targeting the T helper Inflammatory Pathway in Meningoencephalomyelitis of Unknown Origin (MUO)

Barber, R., & Barber, J. (2022). Differential T-cell responses in dogs with meningoencephalomyelitis of unknown origin compared to healthy controls. Frontiers in Veterinary Science, 9. https://www.frontiersin.org/articles/10.3389/fvets.2022.925770

Grant Number: 01844

Research Program Area: Kidney & Urological Disease

Treatment of Urinary Incontinence with Multipotent Muscle Cells: A Regenerative Medicine Approach to a Common Canine Health Problem

Vaden, S. L., Mathews, K. G., Yoo, J., Williams, J. K., Harris, T., Secoura, P., Robertson, J., Gleason, K. L., Reynolds, H., & Piedrahita, J. (2022). The use of autologous skeletal muscle progenitor cells for adjunctive treatment of presumptive urethral sphincter mechanism incompetence in female dogs. Journal of Veterinary Internal Medicinehttps://doi.org/10.1111/jvim.16505

Vaden, S. L., & Elliott, J. (2016). Management of Proteinuria in Dogs and Cats with Chronic Kidney Disease. Vet Clin North Am Small Anim Pract, 46(6), 1115-1130. doi:10.1016/j.cvsm.2016.06.009

Grant Number: 02052

Research Program Area: Immunology and Infectious Disease

Defining the Mechanism of Severe, Life-Threatening Bleeding Disorders in Dogs

Brooks, M. B., Maruyama, H., Cremer, S. E., Goggs, R., Forman, M. A., Koch, M., Merriam, J., Makielski, K., Viall, A., & LeVine, D. N. (2022). Preliminary evaluation of a flow cytometric assay with microsphere controls for the detection of platelet-bound antibodies in canine immune thrombocytopenia. Veterinary Clinical Pathology. https://doi.org/10.1111/vcp.13093

Makielski, K. M., Brooks, M. B., Wang, C., Cullen, J. N., O’Connor, A. M., & LeVine, D. N. (2018). Development and implementation of a novel immune thrombocytopenia bleeding score for dogs. Journal of Veterinary Internal Medicine, 32(3), 1041–1050. https://doi.org/10.1111/jvim.15089

Grant Number: 02936

Research Program Area: Epilepsy Initiative

Validating Genetic Variants Underlying Canine Idiopathic Epilepsy and Exploring Their Functional Roles in the Belgian Sheepdog and Tervuren

Belanger, J. M., Heinonen, T., Famula, T. R., Mandigers, P. J. J., Leegwater, P. A., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2022). Validation of a Chromosome 14 Risk Haplotype for Idiopathic Epilepsy in the Belgian Shepherd Dog Found to Be Associated with an Insertion in the RAPGEF5 Gene. Genes, 13(7), 1124. https://doi.org/10.3390/genes13071124

Grant Number: 02252

Research Program Area: Epilepsy Initiative

Investigating a Ketogenic Medium-Chain Triglyceride (MCT) Supplement for the Treatment of Drug-Resistant Canine Idiopathic Epilepsy and Its Behavioral Comorbidities

Berk, B. A., Packer, R. M.-A., Fritz, J., & Volk, H. A. (2022). Oral Palatability Testing of a Medium-Chain Triglyceride Oil Supplement (MCT) in a Cohort of Healthy Dogs in a Non-Clinical Setting. Animals, 12(13), 1639. https://doi.org/10.3390/ani12131639

Berk, B. A., Packer, R. M. A., Law, T. H., Wessmann, A., Bathen-Nöthen, A., Jokinen, T. S., Knebel, A., Tipold, A., Pelligand, L., & Volk, H. A. (2020). Medium-chain triglycerides dietary supplement improves cognitive abilities in canine epilepsy. Epilepsy & Behavior. https://doi.org/10.1016/j.yebeh.2020.107608

Berk, B. A., Law, T. H., Packer, R. M. A., Wessmann, A., Bathen‐Nöthen, A., Jokinen, T. S., Knebel, A., Tipold, A., Pelligand, L., Meads, Z., & Volk, H. A. (2020). A multicenter randomized controlled trial of effect of medium-chain triglyceride dietary supplementation on epilepsy in dogs. Journal of Veterinary Internal Medicine, 1–2. https://doi.org/10.1111/jvim.15756

Berk, B. A., Packer, R. M. A., Law, T. H., Wessmann, A., Bathen-Nöthen, A., Jokinen, T. S., … Volk, H. A. (2019). A double-blinded randomised dietary supplement crossover trial design to investigate the short-term influence of medium chain fatty acid (MCT) supplement on canine idiopathic epilepsy: study protocol. BMC Veterinary Research, 15(1), 181. https://doi.org/10.1186/s12917-019-1915-8

Watson, F., Packer, R. M. A., Rusbridge, C., & Volk, H. A. (2019). Behavioural changes in dogs with idiopathic epilepsy. Veterinary Record. https://doi.org/10.1136/vr.105222

Berk, B. A., Packer, R. M. A., Law, T. H., & Volk, H. A. (2018). Investigating owner use of dietary supplements in dogs with idiopathic epilepsy. Research in Veterinary Science, 119, 276–284. https://doi.org/10.1016/j.rvsc.2018.07.004

Packer, R. M. A., Volk, H. A., & Fowkes, R. C. (2017). Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers. Physiology & Behavior, 177, 27–33. https://doi.org/10.1016/j.physbeh.2017.04.008

Grant Number: 02806-MOU

Research Program Area: Oncology - Hemangiosarcoma

Strategic Prevention of Canine Hemangiosarcoma: Lifetime Follow-Up

Sarver, A. L., Makielski, K. M., DePauw, T. A., Schulte, A. J., & Modiano, J. F. (2022). Increased risk of cancer in dogs and humans: A consequence of recent extension of lifespan beyond evolutionarily determined limitations? Aging and Cancer. https://doi.org/10.1002/aac2.12046

Grant Number: 1613

Research Program Area: Epilepsy Initiative

Development of a Genetic Marker for Idiopathic Epilepsy in the Belgian Tervuren and Belgian Sheepdog

Belanger, J. M., Heinonen, T., Famula, T. R., Mandigers, P. J. J., Leegwater, P. A., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2022). Validation of a Chromosome 14 Risk Haplotype for Idiopathic Epilepsy in the Belgian Shepherd Dog Found to Be Associated with an Insertion in the RAPGEF5 Gene. Genes, 13(7), 1124. https://doi.org/10.3390/genes13071124

Belanger, J. M., Famula, T. R., Gershony, L. C., Palij, M. K., & Oberbauer, A. M. (2020). Genome-wide association analysis of idiopathic epilepsy in the Belgian Shepherd. Canine Medicine and Genetics, 7(1), 12. https://doi.org/10.1186/s40575-020-00091-x

Oberbauer, A. M. (2003). The Genetics of Epilepsy in the Belgian Tervuren and Sheepdog. Journal of Heredity, 94(1), 57–63. https://doi.org/10.1093/jhered/esg010

Oberbauer, Anita M., Belanger, J. M., Grossman, D. I., Regan, K. R., & Famula, T. R. (2010). Genome-wide linkage scan for loci associated with epilepsy in Belgian Shepherd Dogs. BMC Genetics, 11, 35. https://doi.org/10.1186/1471-2156-11-35

Grant Number: 02669-A

Research Program Area: Reproductive Conditions

Lipid Composition and Lipid Droplet Dynamics in Canine Pyometra Affected Endometria

Leitner, N., Hlavaty, J., Heider, S., Ertl, R., Gabriel, C., & Walter, I. (2022). Lipid droplet dynamics in healthy and pyometra-affected canine endometrium. BMC Veterinary Research, 18(1), 221. https://doi.org/10.1186/s12917-022-03321-5

Grant Number: 02157-MOU

Research Program Area: Neurology

Genomics of Deafness in the Dalmatian

Haase, B., Willet, C. E., Chew, T., Samaha, G., Child, G., & Wade, C. M. (2022). De-novo and genome-wide meta-analyses identify a risk haplotype for congenital sensorineural deafness in Dalmatian dogs. Scientific Reports, 12(1), 15439. https://doi.org/10.1038/s41598-022-19535-4

Brancalion, L., Haase, B., Mazrier, H., Willet, C. E., Lindblad‐Toh, K., Lingaas, F., & Wade, C. M. (2021). Roan, ticked and clear coat patterns in the canine are associated with three haplotypes near usherin on CFA38. Animal Genetics. https://doi.org/10.1111/age.13040

Brancalion, L., Haase, B., Willet, C. E., & Wade, C. M. (2021). Sequence variants of the canine melanocyte inducing transcription factor (MITF) locus reveal a common MITF-A processed pseudogene. Animal Genetics, 52(5), 777–778. https://doi.org/10.1111/age.13106

Grant Number: 01918-G

Research Program Area: Oncology - Lymphoma

Discovery of Biomarkers to Detect Lymphoma Risk, Classify For Treatment, and Predict Outcome in Golden Retrievers

Chu, S., Avery, A., Yoshimoto, J., & Bryan, J. N. (2022). Genome wide exploration of the methylome in aggressive B-cell lymphoma in Golden Retrievers reveals a conserved hypermethylome. Epigenetics, 0(0), 1–17. https://doi.org/10.1080/15592294.2022.2105033

Grant Number: 1771

Research Program Area: Immunology and Infectious Disease

Defining the Unique Genetic Markers in Dogs That Define Immune Function, Disease Resistance and Tissue Transplantation

Pyo, C.-W., Harkey, M. A., Torok-Storb, B., Storb, R., Wang, R., Thomas, A. S., Nelson, W. C., & Geraghty, D. E. (2022). Genotyping of canine MHC gene DLA-88 by next-generation sequencing reveals high frequencies of new allele discovery and gene duplication. HLA. https://doi.org/10.1111/tan.14752

Harkey, M. A., Villagran, A. M., Venkataraman, G. M., Leisenring, W. M., Hullar, M. A. J., & Torok-Storb, B. J. (2017). Associations between gastric dilatation-volvulus in Great Danes and specific alleles of canine immune-system genes DLA88, DRB1, and TLR5. American Journal of Veterinary Research, 78(8), 12.

Hullar, M. A. J., Lampe, J. W., Torok-Storb, B. J., & Harkey, M. A. (2018). The canine gut microbiome is associated with higher risk of gastric dilatation-volvulus and high risk genetic variants of the immune system. PLOS ONE, 13(6), e0197686. https://doi.org/10.1371/journal.pone.0197686

Tsai, K. L., Starr-Moss, A. N., Venkataraman, G. M., Robinson, C., Kennedy, L. J., Steiner, J. M., & Clark, L. A. (2013). Alleles of the major histocompatibility complex play a role in the pathogenesis of pancreatic acinar atrophy in dogs. Immunogenetics, 65(7), 501–509. https://doi.org/10.1007/s00251-013-0704-y

Venkataraman, G. M., Geraghty, D., Fox, J., Graves, S. S., Zellmer, E., Storer, B. E., … Storb, R. (2013). Canine DLA-79 gene: an improved typing method, identification of new alleles and its role in graft rejection and graft-versus-host disease. Tissue Antigens, 81(4), 204–211. https://doi.org/10.1111/tan.12094

Venkataraman, G. M., Kennedy, L. J., Little, M.-T. E., Graves, S. S., Harkey, M. A., Torok-Storb, B. J., & Storb, R. (2017). Thirteen novel canine dog leukocyte antigen-88 alleles identified by sequence-based typing. HLA, 90(3), 165–170. https://doi.org/10.1111/tan.13077

Grant Number: 02709

Research Program Area: Gastrointestinal Disease

Identification of Genetic Risk Factors Contributing to Gastrointestinal Motility Disorders

Bell, S. M., Evans, J. M., Evans, K. M., Tsai, K. L., Noorai, R. E., Famula, T. R., Holle, D. M., & Clark, L. A. (2022). Congenital idiopathic megaesophagus in the German shepherd dog is a sex-differentiated trait and is associated with an intronic variable number tandem repeat in Melanin-Concentrating Hormone Receptor 2. PLOS Genetics, 18(3), e1010044. https://doi.org/10.1371/journal.pgen.1010044

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