Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 02162-MOU Research Program Area: Neurology |
Defining The Genetic Foundations of Chiari-Like Malformation and Syringomyelia as a Tool to Better Treat Neuropathic Pain in the Dog Sparks, C. R., Woelfel, C., Robertson, I., & Olby, N. J. (2021). Association between filum terminale internum length and pain in Cavalier King Charles spaniels with and without syringomyelia. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16023 Sparks, C. R., Cerda‐Gonzalez, S., Griffith, E. H., Lascelles, B. D. X., & Olby, N. J. (2018). Questionnaire-based Analysis of Owner-reported Scratching and Pain Signs in Cavalier King Charles Spaniels Screened for Chiari-like Malformation and Syringomyelia. Journal of Veterinary Internal Medicine, 32(1), 331–339. https://doi.org/10.1111/jvim.14856 Sparks, C. R., Robertson, I., & Olby, N. J. (2019). Morphometric analysis of spinal cord termination in Cavalier King Charles Spaniels. Journal of Veterinary Internal Medicine, 1–9. https://doi.org/10.1111/jvim.15437 Sparks, Courtney R., Gorney, A., Williams, K., Griffith, E. H., Cerda‐Gonzalez, S., Lascelles, B. D. X., & Olby, N. J. (2018). Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari-like malformations and syringomyelia. Journal of Veterinary Internal Medicine, 32(6), 2021–2028. https://doi.org/10.1111/jvim.15297 |
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Grant Number: 02456-A Research Program Area: Oncology |
The Impact of Intravenous Anesthetic Agents on Canine Natural Killer Cell Barr, C. A., Alvarado, F., Chang, Y.-M., Luo, J., & Garden, O. A. (2021). The impact of alfaxalone, propofol and ketamine on canine peripheral blood lymphocyte cytotoxicity in vitro. Research in Veterinary Science, 136, 182–184. https://doi.org/10.1016/j.rvsc.2021.02.019 |
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Grant Number: 02528 Research Program Area: Tick-Borne Disease Initiative |
Developing a Next Generation Sequencing Diagnostic Platform for Tickborne Diseases Oney, K., Koo, M., Roy, C., Ren, S., Qurollo, B., Juhasz, N. B., Vasconcelos, E. J. R., Oakley, B., & Diniz, P. P. V. P. (2021). Evaluation of a commercial microbial enrichment kit used prior DNA extraction to improve the molecular detection of vector-borne pathogens from naturally infected dogs. Journal of Microbiological Methods, 106163. https://doi.org/10.1016/j.mimet.2021.106163 |
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Grant Number: 02380-A Research Program Area: Immunology and Infectious Disease |
Estimating Prevalence and Identifying Risk Factors for Canine Leptospirosis in North America Smith, A. M., Stull, J. W., Evason, M. D., Weese, J. S., Wittum, T. E., Szlosek, D., & Arruda, A. G. (2021). Investigation of spatio-temporal clusters of positive leptospirosis polymerase chain reaction test results in dogs in the United States, 2009 to 2016. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16060 -Leptospirosis Information for Dog Owners Smith, A. M., Arruda, A. G., Evason, M. D., Weese, J. S., Wittum, T. E., Szlosek, D., & Stull, J. W. (2019). A cross-sectional study of environmental, dog, and human-related risk factors for positive canine leptospirosis PCR test results in the United States, 2009 to 2016. BMC Veterinary Research, 15(1), 412. doi.org/10.1186/s12917-019-2148-6 |
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Grant Number: 2646 Research Program Area: Musculoskeletal Conditions and Disease |
Effect of Hyperthermia on Skeletal Muscle Energy Efficiency Davis, M. S., & Barrett, M. R. (2021). Effect of conditioning and physiology hyperthermia on canine skeletal muscle mitochondrial oxygen consumption. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00969.2020 |
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Grant Number: 01986 Research Program Area: Hepatic Disease |
Profiling the Metabolic and Lipid Imbalances that are Causative of Gallbladder Disease in Dogs Lindaberry, C., Vaden, S., Aicher, K. M., Seiler, G., Robertson, J., Cianciolo, R., Yang, C., & Gookin, J. L. (2021). Proteinuria in dogs with gallbladder mucocele formation: A retrospective case control study. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16051 Aicher, K., Cullen, J., Gookin, J., Seiler, G., Lunn, K., Mathews, K., & Correa, M. (2016). HP02 Association of gallbladder mucocele formation with occult hypothyroidism in dogs: A matched case-controlled study. Journal of Veterinary Internal Medicine. 40(4), 1407-1519. https://doi.org/10.1111/jvim.13952 Aicher, K. M., Cullen, J. M., Seiler, G. S., Lunn, K. F., Mathews, K. G., & Gookin, J. L. (2019). Investigation of adrenal and thyroid gland dysfunction in dogs with ultrasonographic diagnosis of gallbladder mucocele formation. PLOS ONE, 14(2), e0212638. https://doi.org/10.1371/journal.pone.0212638 Gookin, J. L., Correa, M. T., Peters, A., Malueg, A., Mathews, K. G., Cullen, J., & Seiler, G. (2015). Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study. Journal of Veterinary Internal Medicine, 29(6), 1464-1472. https://doi.org/10.1111/jvim.13649 Gookin, J. L., Mathews, K. G., Cullen, J., & Seiler, G. (2018). Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation. PLOS ONE, 13(1), e0191076. https://doi.org/10.1371/journal.pone.0191076 |
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Grant Number: 01889-G Research Program Area: Oncology |
Innovations in Prevention, Diagnosis, and Treatment of Cancer - Goldens Lead the Way Kim, J. H., Megquier, K., Thomas, R., Sarver, A. L., Song, J. M., Kim, Y. T., Cheng, N., Schulte, A. J., Linden, M. A., Murugan, P., Oseth, L., Forster, C. L., Elvers, I., Swofford, R., Turner-Maier, J., Karlsson, E. K., Breen, M., Lindblad-Toh, K., & Modiano, J. F. (2021). Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0937 Borgatti, A., Fieberg, A., Winter, A. L., Stuebner, K., Taras, E., Todhunter, D., Masyr, A., Rendhal, A., Vallera, D. A., Koopmeiners, J. S., & Modiano, J. F. (2020). Impact of Repeated Cycles of EGF Bispecific Angiotoxin (eBAT) Administered at a Reduced Interval from Doxorubicin Chemotherapy in Dogs with Splenic Hemangiosarcoma. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12590
Borgatti, A., Koopmeiners, J. S., Sarver, A. L., Winter, A. L., Stuebner, K., Todhunter, D., … Vallera, D. A. (2017). Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR. Molecular Cancer Therapeutics, 16(5), 956–965. https://doi.org/10.1158/1535-7163.MCT-16-0637
Elvers, I., Turner-Maier, J., Swofford, R., Koltookian, M., Johnson, J., Stewart, C., … Alföldi, J. (2015). Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background. Genome Research, 25(11), 1634–1645. https://doi.org/10.1101/gr.194449.115
Gorden, B. H., Kim, J.-H., Sarver, A. L., Frantz, A. M., Breen, M., Lindblad-Toh, K., … Dickerson, E. B. (2014). Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization. The American Journal of Pathology, 184(4), 985–995. https://doi.org/10.1016/j.ajpath.2013.12.025
Im, K. S., Graef, A. J., Breen, M., Lindblad-Toh, K., Modiano, J. F., & Kim, J.-H. (2015). Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma: CXCR4/CXCL12 in HSA migration and invasion. Veterinary and Comparative Oncology, 15(2), 315–327. https://doi.org/10.1111/vco.12165
Seelig, D. M., Ito, D., Forster, C. L., Yoon, U. A., Breen, M., Burns, L. J., … Linden, M. A. (2017). Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies. Leukemia & Lymphoma, 58(7), 1702–1710. https://doi.org/10.1080/10428194.2016.1260122
Thomas, R., Borst, L., Rotroff, D., Motsinger-Reif, A., Lindblad-Toh, K., Modiano, J. F., & Breen, M. (2014). Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma. Chromosome Research, 22(3), 305–319. https://doi.org/10.1007/s10577-014-9406-z
Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922
Megquier, K., Turner-Maier, J., Swofford, R., Kim, J.-H., Sarver, A. L., Wang, C., … Lindblad-Toh, K. (2019). Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma. Molecular Cancer Research, 17(12), 2410–2421 https://doi.org/10.1158/1541-7786.MCR-19-0221 |
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Grant Number: 2292 Research Program Area: Tick-Borne Disease Initiative |
Broad-Range Detection of Canine Tick-Borne Disease and Improved Diagnostics Using Next-Generation Sequencing Oney, K., Koo, M., Roy, C., Ren, S., Qurollo, B., Juhasz, N. B., Vasconcelos, E. J. R., Oakley, B., & Diniz, P. P. V. P. (2021). Evaluation of a commercial microbial enrichment kit used prior DNA extraction to improve the molecular detection of vector-borne pathogens from naturally infected dogs. Journal of Microbiological Methods, 106163. https://doi.org/10.1016/j.mimet.2021.106163 |
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Grant Number: 02446 Research Program Area: Oncology |
Development of Genetic Biomarkers to Improve Diagnosis and Treatment of Canine Histiocytic Sarcoma Hédan, B., Cadieu, É., Rimbault, M., Vaysse, A., Citres, C. D. de, Devauchelle, P., Botherel, N., Abadie, J., Quignon, P., Derrien, T., & André, C. (2021). Identification of common predisposing loci to hematopoietic cancers in four dog breeds. PLOS Genetics, 17(4), e1009395. https://doi.org/10.1371/journal.pgen.1009395 Prouteau, A., Denis, J. A., De Fornel, P., Cadieu, E., Derrien, T., Kergal, C., Botherel, N., Ulvé, R., Rault, M., Bouzidi, A., François, R., Dorso, L., Lespagnol, A., Devauchelle, P., Abadie, J., André, C., & Hédan, B. (2021). Circulating tumor DNA is detectable in canine histiocytic sarcoma, oral malignant melanoma, and multicentric lymphoma. Scientific Reports, 11(1), 877. https://doi.org/10.1038/s41598-020-80332-y Hédan, B., Rault, M., Abadie, J., Ulvé, R., Botherel, N., Devauchelle, P., Copie‐Bergman, C., Cadieu, E., Parrens, M., Alten, J., Zalcman, E. L., Cario, G., Damaj, G., Mokhtari, K., Loarer, F. L., Coulomb‐Lhermine, A., Derrien, T., Hitte, C., Bachelot, L., … André, C. (2020). PTPN11 mutations in canine and human disseminated histiocytic sarcoma. International Journal of Cancer. https://doi.org/10.1002/ijc.32991 |
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Grant Number: 02847-A Research Program Area: General Canine Health |
Assessment of Field Wipe-Down Procedure for Removal of Aerosolized Contaminants on Dogs Perry, E. B., Discepolo, D. R., Liang, S. Y., & Jenkins, E. K. (2021). Removal of Aerosolized Contaminants from Working Canines via a Field Wipe-Down Procedure. Animals, 11(1), 120. https://doi.org/10.3390/ani11010120 |
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Grant Number: 02157-MOU Research Program Area: Neurology |
Genomics of Deafness in the Dalmatian Brancalion, L., Haase, B., Mazrier, H., Willet, C. E., Lindblad‐Toh, K., Lingaas, F., & Wade, C. M. (2021). Roan, ticked and clear coat patterns in the canine are associated with three haplotypes near usherin on CFA38. Animal Genetics. https://doi.org/10.1111/age.13040 |
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Grant Number: 00754A Research Program Area: Oncology |
Mapping of the Gene for Transitional Cell Carcinoma in the Scottish Terrier & West Highland White Terrier Parker, H. G., Dhawan, D., Harris, A. C., Ramos-Vara, J. A., Davis, B. W., Knapp, D. W., & Ostrander, E. A. (2020). RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors BMC Cancer, 20(251). doi.org/10.1186/s12885-020-06737-0
Decker, B., Parker, H. G., Dhawan, D., Kwon, E. M., Karlins, E., Davis, B. W., … Ostrander, E. A. (2015). Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer--Evidence for a Relevant Model System and Urine-Based Diagnostic Test. Molecular Cancer Research, 13(6), 993–1002. https://doi.org/10.1158/1541-7786.MCR-14-0689
Dhawan, D., Ramos-Vara, J. A., Stewart, J. C., Zheng, R., & Knapp, D. W. (2009). Canine invasive transitional cell carcinoma cell lines: In vitro tools to complement a relevant animal model of invasive urinary bladder cancer. Urologic Oncology: Seminars and Original Investigations, 27(3), 284–292. https://doi.org/10.1016/j.urolonc.2008.02.015
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Grant Number: 02633 Research Program Area: Immunology and Infectious Disease |
Validation and Diagnostic Performance of a Novel Monoclonal Antibody based Histoplasma Urine Immunoassay in Dogs with Histoplasmosis Clark, K., & Hanzlicek, A. S. (2020). Evaluation of a novel monoclonal antibody-based enzyme immunoassay for detection of Histoplasma antigen in urine of dogs. Journal of Veterinary Internal Medicine, 1–20. https://doi.org/10.1111/jvim.16006 |
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Grant Number: 961 Research Program Area: General Canine Health |
Medical Surveillance of Dogs Deployed to the World Trade Center and the Pentagon Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 Hunt, M., Otto, C. M., Serpell, J. A., & Alvarez, J. (2012). Interactions between Handler Well-Being and Canine Health and Behavior in Search and Rescue Teams. Anthrozoös, 25(3), 323–335. https://doi.org/10.2752/175303712X13403555186253 Otto, C. M., Downend, A. B., Moore, G. E., Daggy, J. K., Ranivand, D. L., Reetz, J. A., & Fitzgerald, S. D. (2009). Medical surveillance of search dogs deployed to the World Trade Center and Pentagon: 2001-2006. Journal of Veterinary Behavior, 4(6), 241. https://doi.org/10.1016/j.jveb.2009.04.002 Otto, C. M., Franz, M. A., Kellogg, B., Lewis, R., Murphy, L., & Lauber, G. (2002). Field treatment of search dogs: Lessons learned from the World Trade Center disaster: Field treatment of search dogs. Journal of Veterinary Emergency and Critical Care, 12(1), 33–41. https://doi.org/10.1046/j.1435-6935.2002.00004.x New article: Surveillance of Search Dogs | Breeding Better Dogs. (2019). Retrieved November 4, 2019, from https://breedingbetterdogs.com/article/surveillance-search-dogs |
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Grant Number: 02518 Research Program Area: Behavior |
The Effects of Early Life Experience on Working Dog Temperament and Cognition Bray, E. E., Gruen, M. E., Gnanadesikan, G. E., Horschler, D. J., Levy, K. M., Kennedy, B. S., Hare, B. A., & MacLean, E. L. (2020). Dog cognitive development: A longitudinal study across the first 2 years of life. Animal Cognition. https://doi.org/10.1007/s10071-020-01443-7 Bray, E. E., Gruen, M. E., Gnanadesikan, G. E., Horschler, D. J., Levy, K. M., Kennedy, B. S., Hare, B. A., & MacLean, E. L. (2020). Cognitive characteristics of 8- to 10-week-old assistance dog puppies. Animal Behaviour, 166, 193–206. https://doi.org/10.1016/j.anbehav.2020.05.019 Bray, E. E., Levy, K. M., Kennedy, B. S., Duffy, D. L., Serpell, J. A., & MacLean, E. L. (2019). Predictive Models of Assistance Dog Training Outcomes Using the Canine Behavioral Assessment and Research Questionnaire and a Standardized Temperament Evaluation. Frontiers in Veterinary Science, 6 (49). https://doi.org/10.3389/fvets.2019.00049 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
