02407-A: In vitro Efficacy of Nano-sulfur Against Planktonic and Biofilm State of Resistant Bacteria

Grant Status: Open

Grant Amount: $14,958
Domenico Santoro, DVM, MS, DrSc, PhD; University of Florida
May 1, 2018 - October 31, 2019
Sponsor(s): AKC Reunite, American Boxer Charitable Foundation
Breed(s): -All Dogs
Disease(s): Antibiotic Resistant Bacteria
Research Program Area: Immunology and Infectious Disease

Abstract

Antibiotic resistance and biofilm are emerging problems in both human and veterinary medicine. The inappropriate use of antibiotics helps selecting for resistant strains. Biofilms have an increased resistance pattern due to the presence of a shield that hinders penetration of antibiotics. Currently few antimicrobial options are available for resistant bacteria and biofilm causing major concerns for post-surgical patients. Over the past years, the increased development of nanotechnologies has made the fight against bacteria easier and safer due to the use of lower antimicrobial doses, reduced side effects, and increased antimicrobial efficacy. The most commonly used nano-antimicrobial is nano-silver. However, despite its efficacy, worries persist regarding its safety profile and environmental toxicity. Another emerging nano-antimicrobial is nano-sulfur; widely used in the agricultural industry. Sulfur has been a well-known and safe antimicrobial for centuries, however, its efficacy as nano-particles against biofilm formation/disruption is unknown. The investigators will evaluate the efficacy of nano-sulfur against resistant bacteria and in preventing and/or disrupting biofilm l with on multidrug-resistant Staphylococci (S. aureus and S. pseudintermedius) and Pseudomonas aeruginosa. This study will determine 1) whether nano-sulfur is effective against bacterial growth and biofilm  adhesion/formation/disruption; 2) if nano-sulfur is cytotoxic at antimicrobial concentrations. If proven effective, nano-sulfur will provide a cheaper and safer treatment for antibiotic-resistance and biofilms.

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