Oncology Grants

In continuation of CHF’s strong support of canine cancer research, the Oncology Research Program Area remains committed to innovative research that will aid in the discovery of advanced diagnostic technology and therapeutic target identification.

To make sense of the complexity of cancer, new approaches are needed to provide comprehensive characterization of tumors and other canine cancers. These approaches will likely require broad bioinformatic analyses, high throughput methodologies and systems biology tools.

Active Grants:

 02907 Ultrasound-guided Histotripsy Ablation of Canine Brain Tumors through an Acoustically Transparent Cranial Window
 02880 Enhanced Surgical Margin Imaging with Polarization-sensitive Optical Coherence Tomography in Canine Soft Tissue Sarcoma and Mammary Tumors
 02855-A Repurposing Drugs to Modulate Myeloid-derived Suppressor Cells (MDSCs) in Canine Soft Tissue Sarcomas
 02879 Use of CRISPR-based Genome-wide Approach for Identification of Vulnerabilities in Canine Oral Melanoma
 02910 Open-Label, Phase-2 Clinical Trial of Chlorambucil and Toceranib for Canine Mast Cell Tumors
 02920 Continued Investigation into Tumor-permissive Collagen Signatures in Canine Mammary Gland Tumors: Development of Prognostic Markers and Targeted Therapies for Improved Outcomes
 02858-A Investigation of Mechanisms of Resistance to Immunotherapy in Dogs with Spontaneous High-grade Glioma
 02758 Optical Coherence Tomography for Margin Evaluation of Canine Skin and Subcutaneous Neoplasms
 02780 Bladder Carcinogen Exposures in Pet Dogs
 02783 Transcriptional Profiling of Canine Soft Tissue Sarcoma
 02732-A Tumor-educated Platelets: A Novel Minimally Invasive Liquid Biopsy for Early Cancer Diagnosis
 02595-A Defining the Flow Cytometric Characteristics of Normal and Diseased Canine Spleen and Visceral Lymph Nodes
 02663 Comparative Brain Tumor Consortium (CBTC) Meningioma Pathology Board
 02446 Development of Genetic Biomarkers to Improve Diagnosis and Treatment of Canine Histiocytic Sarcoma
 02487 OX40 Checkpoint Molecule Targeted Antibodies for Cancer Immunotherapy in Dogs
 02500 Immune Targeting of the V600E B-Raf Neoantigen in Canine Urothelial Carcinoma

Previously Awarded Grants:

 02643-A Examination of the Effects of Cannabidiol on Canine Neoplastic Cell Apoptosis/Autophagy and Potential for Chemotherapy Resistance or Sensitivity
 02321 Clinical Trial of Procaspase-3 Activator (PAC-1) in Combination with Hydroxyurea for Treatment of Canine Meningioma
 02636-A Development of RNA in-situ Hybridization to Identify T Regulatory Cells and their Function within the Tumor Microenvironment of Canine Oral Malignant Melanoma
 02489 Tumor-permissive Collagen Signatures in Canine Mammary Gland Tumors: Development of Prognostic Markers and Targeted Therapies for Improved Outcomes
 02456-A The Impact of Intravenous Anesthetic Agents on Canine Natural Killer Cell
 02455-A Identification of genetic mutations in anal sac carcinoma in English Cocker Spaniels
 02204-T Using Enhanced Imaging to Evaluate Tumor Margins for Canine Mammary Cancer and Soft Tissue Sarcoma
 02522-A The Investigation of Lypoxigenase-5 Expression in Canine Normal, Hyperplastic and Neoplastic Urinary Bladder Epithelium
 02405-A Transcriptome Based Diagnostics in Canine Soft Tissue Sarcoma
 2217 A Novel Mechanism to Regulate the Growth of Canine Hemangiosarcoma
 02237-A Capturing Tumor Cells in Canine Blood
 02215 A Cancer Vaccine for Canine Osteosarcoma
 01889-G Innovations in Prevention, Diagnosis, and Treatment of Cancer - Goldens Lead the Way
 02171-MOU Histiocytic Sarcoma in Bernese Mountain Dogs: Novel Approaches To Treatment
 01826 A Novel Treatment for Brain Tumors Using a One Medicine Approach
 02244-A Beyond Peto's Paradox with the Geriatric Peromyscus
 01689-A Increasing the Effectiveness of Radiation Therapy in Treatment of Mast Cell Tumors
 02071 Development of a Therapeutic Brain Tumor Vaccine
 02093-A Sequencing Histiocytic Sarcoma (HS) loci identified by Genetic Association studies in the Bernese Mountain Dog (BMD)
 02091-A Differentiating between Localized and Disseminated Histiocytic Sarcoma in Bernese Mountain Dogs
 01843 Further Investigation of the Genes Controlling Canine Leukemia to Properly Diagnose and Control the Disease
 01822 Beyond the Genome: The Intersection of Genes and the Environment in Canine Cancer
 01872-A Using Ultrasound as a Cost Effective and Non-Invasive Technique for Early Diagnosis of Solid Tumors
 01426 Personalized Medicine for the Treatment of Canine Mast Cell Tumors
 01577 Identifying the Genes Conferring Risk for Transitional Cell Carcinoma

The AKC Canine Health Foundation funds research in 23 different Research Program Areas for the health of all dogs. These program areas enable the Foundation to create depth in our research portfolio and help us to be responsive to the health concerns of our constituents.

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Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

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