Oncology Grants

In continuation of CHF’s strong support of canine cancer research, the Oncology Research Program Area remains committed to innovative research that will aid in the discovery of advanced diagnostic technology and therapeutic target identification.

To make sense of the complexity of cancer, new approaches are needed to provide comprehensive characterization of tumors and other canine cancers. These approaches will likely require broad bioinformatic analyses, high throughput methodologies and systems biology tools.

Active Grants:

 3195 Early Genetic Markers of Histiocytic Sarcoma for Faster Diagnosis and More Effective Treatment
 03228 Identification of Tumor-Specific Proteins for Targeted Therapy in Solid and Disseminated Histiocytic Sarcoma
 03186-A Comparison of Genomic Mutation Status Between Primary Site and Metastatic Lymph Node in Canine Oral Malignant Melanoma
 03103 Identification of Genetic Mutations in AnalSac Carcinoma Development in English Cocker Spaniels, Part II – Validation
 03100-A The Use of Artificial Intelligence and Computed Tomography Image Features to Predict Sentinel Lymph Node Metastasis in Dogs with Oral Tumours
 02992-A Sentinel Lymph Node Mapping for Dogs with Lung Tumors
 03019 Evaluation of a Targeted Anti αvβ3 Integrin Near-InfraRed (NIR-) Dye for Controlled Resection of Naturally Occurring Soft Tissue Sarcomas in Dogs
 03009 Evaluating Accuracy for Identification of Sentinel Lymph Nodes in Dogs with Cutaneous MCT: A Comparison
 03017 Molecular Characterization of Canine Soft Tissue Sarcomas Using Spatially Defined Proteomics and Transcriptomics
 02987 It’s All In The Genes: The Mutational Landscape of Acute Myeloid Leukemia in Dogs
 02907 Ultrasound-guided Histotripsy Ablation of Canine Brain Tumors through an Acoustically Transparent Cranial Window
 02880 Enhanced Surgical Margin Imaging with Polarization-sensitive Optical Coherence Tomography in Canine Soft Tissue Sarcoma and Mammary Tumors
 02920 Continued Investigation into Tumor-permissive Collagen Signatures in Canine Mammary Gland Tumors: Development of Prognostic Markers and Targeted Therapies for Improved Outcomes
 02879 Use of CRISPR-based Genome-wide Approach for Identification of Vulnerabilities in Canine Oral Melanoma
 02910 Open-Label, Phase-2 Clinical Trial of Chlorambucil and Toceranib for Canine Mast Cell Tumors
 02855-A Repurposing Drugs to Modulate Myeloid-derived Suppressor Cells (MDSCs) in Canine Soft Tissue Sarcomas
 02732-A Tumor-educated Platelets: A Novel Minimally Invasive Liquid Biopsy for Early Cancer Diagnosis
 02663 Comparative Brain Tumor Consortium (CBTC) Meningioma Pathology Board

Previously Awarded Grants:

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 02780 Bladder Carcinogen Exposures in Pet Dogs
 02783 Transcriptional Profiling of Canine Soft Tissue Sarcoma
 02858-A Investigation of Mechanisms of Resistance to Immunotherapy in Dogs with Spontaneous High-grade Glioma
 02758 Optical Coherence Tomography for Margin Evaluation of Canine Skin and Subcutaneous Neoplasms
 02487 OX40 Checkpoint Molecule Targeted Antibodies for Cancer Immunotherapy in Dogs
 02446 Development of Genetic Biomarkers to Improve Diagnosis and Treatment of Canine Histiocytic Sarcoma
 02595-A Defining the Flow Cytometric Characteristics of Normal and Diseased Canine Spleen and Visceral Lymph Nodes
 02643-A Examination of the Effects of Cannabidiol on Canine Neoplastic Cell Apoptosis/Autophagy and Potential for Chemotherapy Resistance or Sensitivity
 02321 Clinical Trial of Procaspase-3 Activator (PAC-1) in Combination with Hydroxyurea for Treatment of Canine Meningioma
 02500 Immune Targeting of the V600E B-Raf Neoantigen in Canine Urothelial Carcinoma
 02636-A Development of RNA in-situ Hybridization to Identify T Regulatory Cells and their Function within the Tumor Microenvironment of Canine Oral Malignant Melanoma
 02489 Tumor-permissive Collagen Signatures in Canine Mammary Gland Tumors: Development of Prognostic Markers and Targeted Therapies for Improved Outcomes
 02456-A The Impact of Intravenous Anesthetic Agents on Canine Natural Killer Cell
 02455-A Identification of genetic mutations in anal sac carcinoma in English Cocker Spaniels
 02204-T Using Enhanced Imaging to Evaluate Tumor Margins for Canine Mammary Cancer and Soft Tissue Sarcoma
 02522-A The Investigation of Lypoxigenase-5 Expression in Canine Normal, Hyperplastic and Neoplastic Urinary Bladder Epithelium
 02405-A Transcriptome Based Diagnostics in Canine Soft Tissue Sarcoma
 2217 A Novel Mechanism to Regulate the Growth of Canine Hemangiosarcoma
 02237-A Capturing Tumor Cells in Canine Blood
 02215 A Cancer Vaccine for Canine Osteosarcoma
 02171-MOU Histiocytic Sarcoma in Bernese Mountain Dogs: Novel Approaches To Treatment
 01889-G Innovations in Prevention, Diagnosis, and Treatment of Cancer - Goldens Lead the Way
 01826 A Novel Treatment for Brain Tumors Using a One Medicine Approach
 02244-A Beyond Peto's Paradox with the Geriatric Peromyscus
 01689-A Increasing the Effectiveness of Radiation Therapy in Treatment of Mast Cell Tumors

The AKC Canine Health Foundation funds research in 23 different Research Program Areas for the health of all dogs. These program areas enable the Foundation to create depth in our research portfolio and help us to be responsive to the health concerns of our constituents.

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