2455: Identification of genetic mutations in anal sac carcinoma in English Cocker Spaniels

Grant Status: Open

Grant Amount: $15,000
Dr. Shaying Zhao, PhD, University of Georgia
December 1, 2017 - November 30, 2018
Breed(s): English Cocker Spaniel
Research Program Area: Oncology

Abstract

English cocker spaniels (ECSs) are about 7 times more likely than other dog breeds to develop anal sac carcinoma (ASC). Hence, there appears to be a genetic basis for this disease development in ECSs. The investigators will sequence the genomes and transcriptomes of blood and ASC tumor samples collected from ECS dogs across the US. The samples will be studied alongside the pedigree information and medical records. Using dog-human comparative genomics and oncology strategy for cancer-causative mutation discovery, successful identification of mutations in ASC development in ECSs may lead to the development of genetic tests of this aggressive disease in ECSs and yield targets for therapeutic intervention.

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