Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 1660 Research Program Area: Cardiology |
Determination of Viral Contribution to Cardiac Disease in a Select Population of Salukis Lingaas, F., Aarskaug, T., Gerlach, J. A., Juneja, R. K., Fredholm, M., Sampson, J., … Dolf, G. (2001). A canine linkage map: 39 linkage groups. Journal of Animal Breeding and Genetics, 118(1), 3–19. https://doi.org/10.1111/j.1439-0388.2001.00270.x |
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Grant Number: 1608B Research Program Area: General Canine Health |
Integrated Map of Canine Gene and Microsatellite Loci Breen, M. (2001). Chromosome-Specific Single-Locus FISH Probes Allow Anchorage of an 1800-Marker Integrated Radiation-Hybrid/Linkage Map of the Domestic Dog Genome to All Chromosomes. Genome Research, 11(10), 1784–1795. https://doi.org/10.1101/gr.189401 |
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Grant Number: 0001608A Research Program Area: General Canine Health |
Integrated Map of Canine Gene and Microsatellite Loci Jonasdottir, T. J., Mellersh, C. S., Moe, L., Heggebo, R., Gamlem, H., Ostrander, E. A., & Lingaas, F. (2000). Genetic mapping of a naturally occurring hereditary renal cancer syndrome in dogs. Proceedings of the National Academy of Sciences, 97(8), 4132–4137. https://doi.org/10.1073/pnas.070053397
Jónasdóttir, T. J., Mellersh, C. S., Moe, L., Vignaux, F., Ostrander, E. A., & Lingaas, F. (2000). Chromosomal assignment of canine TSC 2, PKD 1 and CLN 3 genes by radiation hybrid- and linkage analyses. Animal Genetics, 31(2), 123–126. https://doi.org/10.1046/j.1365-2052.2000.00601.x |
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Grant Number: 1440 Research Program Area: Blood Disorders |
Evaluating the Causative Mutation for von Willebrand's Disease in the Doberman Pinscher and Its Possible Role in Other Breeds Venta, P. J., Li, J., Yuzbasiyan-Gurkan, V., Brewer, G. J., & Schall, W. D. (2000). Mutation causing von Willebrand’s disease in Scottish Terriers. Journal of Veterinary Internal Medicine, 14(1), 10–19. Retrieved from https://doi.org/10.1111/j.1939-1676.2000.tb01493.x |
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Grant Number: 1273 Research Program Area: Ophthalmology |
Molecular Ophthalmology of Progressive Retinal Atrophy Aguirre, G D, Baldwin, V., Weeks, K. M., Acland, G. M., & Ray, K. (1999). Frequency of the Codon 807 Mutation in the cGMP Phosphodiesterase ?-Subunit Gene in Irish Setters and Other Dog Breeds with Hereditary Retinal Degeneration. The Journal of Heredity, 90(1), 143–147. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/9987922
Aguirre, Gustavo D, Baldwin, V., Pearce-Kelling, S., & NarfstrÃ, K. (n.d.). Congenital Stationary Night Blindness in the Dog: Common Mutation in the RPE65 Gene Indicates Founder Effect. Molecular Vision, 4(23). Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/9808841
Akhmedov, N B, Piriev, N. I., Pearce-Kelling, S., Acland, G. M., Aguirre, G., & Farber, D. (1998). Canine cone transducin-γ gene and cone degeneration in the cd dog. Investigative Ophthalmology & Visual Science, 39, 1775–1781. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/9727399
Akhmedov, Novrouz B, Baldwin, V., Zangerl, B., Kijas, J. K., Hunter, L. S., Minoofar, K. D., … Aguirre, G. D. (2002). Cloning and Characterization of the Canine Photoreceptor Specific Cone-Rod Homeobox (CRX) Gene and Evaluation as a Candidate for Early Onset Photoreceptor Diseases in the Dog. Molecular Vision, 8, 79–84. Retrieved from http://www.molvis.org/molvis/v8/a11/
Gu, W. (1999). Individual DNA bands obtained by RAPD analysis of canine genomic DNA often contain multiple DNA sequences. Journal of Heredity, 90(1), 96–98. https://doi.org/10.1093/jhered/90.1.96
Gu, Weikuan, & Ray, K. (1998). Detection of Single-Nucleotide Polymorphism. BioTechniques, 24, 836–837.
Ray, K. (1999). Strategies for identification of mutations causing hereditary retinal diseases in dogs: Evaluation of opsin as a candidate gene. Journal of Heredity, 90(1), 133–137. https://doi.org/10.1093/jhered/90.1.133
Wang, W., Acland, G. M., Ray, K., & Aguirre, G. D. (1999). Evaluation of cGMP-Phosphodiesterase (PDE) Subunits for Causal Association with Rod–Cone Dysplasia 2 (rcd2), a Canine Model of Abnormal Retinal cGMP Metabolism. Experimental Eye Research, 69(4), 445–453. https://doi.org/10.1006/exer.1999.0720
Zeiss, C. J. (2000). Mapping of X-linked progressive retinal atrophy (XLPRA), the canine homolog of retinitis pigmentosa 3 (RP3). Human Molecular Genetics, 9(4), 531–537. https://doi.org/10.1093/hmg/9.4.531
Zeiss, C. J, Acland, G. M., Aguirre, G. D., & Kunal Ray. (1998). TIMP-1 expression is increased in X-linked progressive retinal atrophy despite its exclusion as a candidate gene. Gene, 225(1–2), 67–75. https://doi.org/10.1016/S0378-1119(98)00521-6
Zeiss, C. J., Aguirre, G. D., & Ray, K. (1998). A highly polymorphic RFLP marker in the canine retinitis pigmentosa GTPase regulator (RPGR) gene. Animal Genetics, 29(5), 409.
Zeiss, C. J., Trepanier, L. A., Aguirre, G. D., & Ray, K. (1998). A highly conserved microsatellite in the dystrophin gene of diverse mammalian species. Animal Genetics, 29(3), 224–227.
Zeiss, Caroline J, Acland, G. M., & Aguirre, G. D. (1999). Retinal Pathology of Canine X-linked Progressive Retinal Atrophy, the Locus Homologue of RP3. Investigative Ophthalmology & Visual Science, 40(13), 13. |
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Grant Number: 1458 Research Program Area: General Canine Health |
Hereditary Hearing Loss in Dalmatians and Australian Cattle Dogs Zemke, D., & Yuzbasiyan-Gurkan, V. (1999). A single nucleotide polymorphism and a (GA)n microsatellite in intron 6 of the canine endothelin receptor B (EDNRB) gene. Animal Genetics, 30(5), 382–383. https://doi.org/10.1046/j.1365-2052.1999.00526.x |
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Grant Number: 1274 Research Program Area: General Canine Health |
Detection of Polymorphism in Comparative Mapping Lyons, L. A. (1999). Development of comparative anchor tagged sequences (CATS) for canine genome mapping. Journal of Heredity, 90(1), 15–26. https://doi.org/10.1093/jhered/90.1.15 |
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Grant Number: 1275 Research Program Area: General Canine Health |
Type I Markers for Canine Homologs Chen, Y. W., Bermudez, A. J., Liu, P. C., Nonneman, D., & Johnson, G. S. (1998). A DraIII PCR/RFLP in an intron of the emu lysosomal protective protein gene. Animal Genetics, 29(5), 404–405.
Chen, Y. W., Liu, P. C., Shibuya, H., O’Brien, D. P., Lubahn, D. B., & Johnson, G. S. (1998). Length polymorphism in a CAG-rich coding region of the canine dentatorubro-pallidoluysian atrophy (DRPLA) gene. Animal Genetics, 29(3), 241.
Ganjam, K. K., Shibuya, H., Stoy, S. J., Liu, P. C., Ganjam, V. K., Katz, M. L., & Johnson, G. S. (1998). A BstUI PCR/RFLP marker in an intron of the canine fibrillin 1 gene. Animal Genetics, 29(3), 240–241.
Guo, Q., Shibuya, H., Nonneman, D., Liu, P. C., Huang, T. H., & Johnson, G. S. (1998). A polymorphic (CA)n microsatellite in the canine lecithin:Cholesterol acyltransferase gene. Animal Genetics, 29(4), 328–329.
Khan, S., Shibuya, H., Nonneman, D., Liu, P. C., Huang, T. H., & Johnson, G. S. (1998). A polymorphic (TG)n microsatellite in an intron of the canine tyrosine transaminase gene. Animal Genetics, 29(4), 322.
Liu, P. C., Chen, Y. W., Shibuya, H., Katz, M. L., Lubahn, D. B., & Johnson, G. S. (1998a). A polymorphic (GA)n microsatellite in an intron of the canine endothelin-B receptor gene. Animal Genetics, 29(3), 236.
Liu, P. C., Chen, Y. W., Shibuya, H., Katz, M. L., Lubahn, D. B., & Johnson, G. S. (1998b). Length polymorphism in a CT-rich microsatellite in an intron of the canine tyrosinase-related protein-2 gene. Animal Genetics, 29(4), 327.
Liu, P. C., Chen, Y. W., Shibuya, H., Lubahn, D. B., & Johnson, G. S. (1998). A length polymorphism in an intron of the canine polycystic kidney disease 1 gene. Animal Genetics, 29(4), 322–323.
Liu, P. C., Shibuya, H., Katz, M. L., & Johnson, G. S. (1998). A BsmFI PCR/RFLP in the canine CD19 gene. Animal Genetics, 29(1), 64–65.
Liu, P. C., Shibuya, H., Lubahn, D. B., & Johnson, G. S. (1998). A polymorphic (CT)n microsatellite in an intron of the canine SA-hypertension gene. Animal Genetics, 29(1), 72.
Liu, P. C., Shibuya, H., Nonneman, D., Katz, M. L., & Johnson, G. S. (1998). A BseRI PCR/RFLP in an intron of the canine phenol sulfotransferase gene. Animal Genetics, 29(4), 329.
Shibuya, H., Cassells, M. W., Huang, T. H., & Johnson, G. S. (1998). A polymorphic (TG)n microsatellite in an intron of the canine angiotensin I converting enzyme gene. Animal Genetics, 29(1), 66–67.
Shibuya, H., Liu, P. C., O’Brien, D. P., Chen, Y. W., & Johnson, G. S. (1998). A BbvI mismatch PCR/RFLP marker for the canine huntingtin gene. Animal Genetics, 29(3), 239–240.
Shibuya, H., Liu, P.-C., Katz, M. L., Siakotos, A. N., Nonneman, D. J., & Johnson, G. S. (1998). Coding sequence and exon/intron organization of the canine CLN3 (batten disease) gene and its exclusion as the locus for ceroid-lipofuscinosis in English Setter dogs. Journal of Neuroscience Research, 52(3), 268–275. https://doi.org/10.1002/(SICI)1097-4547(19980501)52:33.0.CO;2-B
Stoy, S. J., Sibuya, H., O’Brien, D., & Johnson, G. S. (1998). A BslI PCR/RFLP in the renin binding protein (RnBP) gene on canine chromosome X. Animal Genetics, 29(7), 327–328.
Zhou, T., Nonneman, D., Shibuya, H., Khan, S., Liu, P. C., & Johnson, G. S. (1998). An AvaII PCR/RFLP in an exon of the canine gene for the beta subunit of the amiloride-sensitive sodium channel (SCNN1B). Animal Genetics, 29(3), 239.
Zhou, T., Shibuya, H., Liu, P. C., O’Brien, D. P., & Johnson, G. S. (1998). A NlaIII PCR/RFLP in an intron of the retinitis pigmentosa GTPase regulator gene (RPGR) on the canine X chromosome. Animal Genetics, 29(4), 330–331. |
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Grant Number: 02940 Research Program Area: Epilepsy Initiative |
Investigating Neuronal Network Connectivity in Dogs with Idiopathic Epilepsy using Functional Magnetic Resonance Imaging None at this time. |
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Grant Number: 01139 Research Program Area: Oncology - Hemangiosarcoma |
Immune Targeting of Canine Hemangiosarcoma Using a Canine Derived Single Chain Antibody Approach Braganza, A., Wallace, K., Pell, L., Parrish, C. R., Siegel, D. L., & Mason, N. J. (2011). Generation and validation of canine single chain variable fragment phage display libraries. Veterinary Immunology and Immunopathology, 139(1), 27–40. https://doi.org/10.1016/j.vetimm.2010.07.026 |
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Grant Number: 02802 Research Program Area: Neurology |
Clinical Trial of Prevotella histicola Supplementation to Ameliorate Meningoencephalomyelitis of Unknown Origin (MUO) None at this time. |
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Grant Number: 02210 Research Program Area: Neurology |
Gene Therapy for Canine Degenerative Myelopathy None at this time. |
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Grant Number: 02597 Research Program Area: Dermatology and Allergic Disease |
Molecular Epidemiology of Methicillin-resistant Staphylococcus pseudintermedius in the United States
Phophi, Lufuno, Mohamed A. Abouelkhair, Rebekah Jones, Jordan Zehr, and Stephen A. Kania. “Temporal Changes in Antibiotic Resistance and Population Structure of Methicillin-Resistant Staphylococcus Pseudintermedius between 2010 and 2021 in the United States.” Comparative Immunology, Microbiology and Infectious Diseases 100 (September 1, 2023): 102028. https://doi.org/10.1016/j.cimid.2023.102028. |
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Grant Number: 02346-A Research Program Area: Lung and Respiratory Disease |
Blood Culture and Blood Microbiome as Minimally Invasive Diagnostics for Canine Bacterial Pneumonia None at this time. |
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Grant Number: 02694 Research Program Area: Dermatology and Allergic Disease |
Investigation on the Molecular Crosstalk between Canine Atopic Skin and Microbes: Unraveling Potential Pathomechanisms for Chronic Recurrent Skin Infections |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
