1275: Type I Markers for Canine Homologs

Grant Status: Closed

Grant Amount: $54,600
Gary S. Johnson, DVM, PhD; University of Missouri, Columbia
May 22, 1996 - May 21, 1998

Sponsor(s): Alaskan Malamute Research Foundation, Inc., Buckeye Keeshond Club, Keeshond Club of America

Breed(s): -All Dogs
Research Program Area: General Canine Health
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Project Summary

This project sought to identify candidate genes for specific diseases in dogs. Candidate genes are genes known to cause specific diseases in other species. The researchers searched for canine equivalents of three human chromosomes. They identified more than 25 Type I markers (markers that are associated with specific genes). These markers, mapped on the canine genome linkage map, provide valuable information to other scientists looking for the genes causing various heritable diseases in dogs.

Publication(s)

Chen, Y. W., Bermudez, A. J., Liu, P. C., Nonneman, D., & Johnson, G. S. (1998). A DraIII PCR/RFLP in an intron of the emu lysosomal protective protein gene. Animal Genetics, 29(5), 404–405.
 
Chen, Y. W., Liu, P. C., Shibuya, H., O’Brien, D. P., Lubahn, D. B., & Johnson, G. S. (1998). Length polymorphism in a CAG-rich coding region of the canine dentatorubro-pallidoluysian atrophy (DRPLA) gene. Animal Genetics, 29(3), 241.
 
Ganjam, K. K., Shibuya, H., Stoy, S. J., Liu, P. C., Ganjam, V. K., Katz, M. L., & Johnson, G. S. (1998). A BstUI PCR/RFLP marker in an intron of the canine fibrillin 1 gene. Animal Genetics, 29(3), 240–241.
 
Guo, Q., Shibuya, H., Nonneman, D., Liu, P. C., Huang, T. H., & Johnson, G. S. (1998). A polymorphic (CA)n microsatellite in the canine lecithin:Cholesterol acyltransferase gene. Animal Genetics, 29(4), 328–329.
 
Khan, S., Shibuya, H., Nonneman, D., Liu, P. C., Huang, T. H., & Johnson, G. S. (1998). A polymorphic (TG)n microsatellite in an intron of the canine tyrosine transaminase gene. Animal Genetics, 29(4), 322.
 
Liu, P. C., Chen, Y. W., Shibuya, H., Katz, M. L., Lubahn, D. B., & Johnson, G. S. (1998a). A polymorphic (GA)n microsatellite in an intron of the canine endothelin-B receptor gene. Animal Genetics, 29(3), 236.
 
Liu, P. C., Chen, Y. W., Shibuya, H., Katz, M. L., Lubahn, D. B., & Johnson, G. S. (1998b). Length polymorphism in a CT-rich microsatellite in an intron of the canine tyrosinase-related protein-2 gene. Animal Genetics, 29(4), 327.
 
Liu, P. C., Chen, Y. W., Shibuya, H., Lubahn, D. B., & Johnson, G. S. (1998). A length polymorphism in an intron of the canine polycystic kidney disease 1 gene. Animal Genetics, 29(4), 322–323.
 
Liu, P. C., Shibuya, H., Katz, M. L., & Johnson, G. S. (1998). A BsmFI PCR/RFLP in the canine CD19 gene. Animal Genetics, 29(1), 64–65.
 
Liu, P. C., Shibuya, H., Lubahn, D. B., & Johnson, G. S. (1998). A polymorphic (CT)n microsatellite in an intron of the canine SA-hypertension gene. Animal Genetics, 29(1), 72.
 
Liu, P. C., Shibuya, H., Nonneman, D., Katz, M. L., & Johnson, G. S. (1998). A BseRI PCR/RFLP in an intron of the canine phenol sulfotransferase gene. Animal Genetics, 29(4), 329.
 
Shibuya, H., Cassells, M. W., Huang, T. H., & Johnson, G. S. (1998). A polymorphic (TG)n microsatellite in an intron of the canine angiotensin I converting enzyme gene. Animal Genetics, 29(1), 66–67.
 
Shibuya, H., Liu, P. C., O’Brien, D. P., Chen, Y. W., & Johnson, G. S. (1998). A BbvI mismatch PCR/RFLP marker for the canine huntingtin gene. Animal Genetics, 29(3), 239–240.
 
Shibuya, H., Liu, P.-C., Katz, M. L., Siakotos, A. N., Nonneman, D. J., & Johnson, G. S. (1998). Coding sequence and exon/intron organization of the canine CLN3 (batten disease) gene and its exclusion as the locus for ceroid-lipofuscinosis in English Setter dogs. Journal of Neuroscience Research, 52(3), 268–275. https://doi.org/10.1002/(SICI)1097-4547(19980501)52:33.0.CO;2-B
 
Stoy, S. J., Sibuya, H., O’Brien, D., & Johnson, G. S. (1998). A BslI PCR/RFLP in the renin binding protein (RnBP) gene on canine chromosome X. Animal Genetics, 29(7), 327–328.
 
Zhou, T., Nonneman, D., Shibuya, H., Khan, S., Liu, P. C., & Johnson, G. S. (1998). An AvaII PCR/RFLP in an exon of the canine gene for the beta subunit of the amiloride-sensitive sodium channel (SCNN1B). Animal Genetics, 29(3), 239.
 
Zhou, T., Shibuya, H., Liu, P. C., O’Brien, D. P., & Johnson, G. S. (1998). A NlaIII PCR/RFLP in an intron of the retinitis pigmentosa GTPase regulator gene (RPGR) on the canine X chromosome. Animal Genetics, 29(4), 330–331.

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