1275: Type I Markers for Canine Homologs

Grant Status: Closed

Grant Amount: $54,600
Gary S. Johnson, DVM, PhD; University of Missouri, Columbia
May 22, 1996 - May 21, 1998
Sponsor(s): Alaskan Malamute Research Foundation, Inc., Buckeye Keeshond Club, Keeshond Club of America
Breed(s): -All Dogs
Research Program Area: Prevention

Project Summary

This project sought to identify candidate genes for specific diseases in dogs. Candidate genes are genes known to cause specific diseases in other species. The researchers searched for canine equivalents of three human chromosomes. They identified more than 25 Type I markers (markers that are associated with specific genes). These markers, mapped on the canine genome linkage map, provide valuable information to other scientists looking for the genes causing various heritable diseases in dogs.

Publication(s)

Chen, Y. W., Bermudez, A. J., Liu, P. C., Nonneman, D., & Johnson, G. S. (1998). A DraIII PCR/RFLP in an intron of the emu lysosomal protective protein gene. Anim Genet, 29(5), 404-405.

Chen, Y. W., Liu, P. C., Shibuya, H., O'Brien, D. P., Lubahn, D. B., & Johnson, G. S. (1998). Length polymorphism in a CAG-rich coding region of the canine dentatorubro-pallidoluysian atrophy (DRPLA) gene. Anim Genet, 29(3), 241.

Ganjam, K., Shibuya, H., Stoy, S., Liu, P., Ganjam, V., Katz, M., & Johnson, G. (1998). Abst Ui Pcr/rflp marker in an intron of the canine fibrillin 1 gene. Anim Genet, 29(3), 240-241.

Guo, Q., Shibuya, H., Nonneman, D., Liu, P. C., Huang, T. H., & Johnson, G. S. (1998). A polymorphic (CA)n microsatellite in the canine lecithin:cholesterol acyltransferase gene. Anim Genet, 29(4), 328-329.

Khan, S., Shibuya, H., Nonneman, D., Liu, P. C., Huang, T. H., & Johnson, G. S. (1998). A polymorphic (TG)n microsatellite in an intron of the canine tyrosine transaminase gene. Anim Genet, 29(4), 322.

Liu, P. C., Chen, Y. W., Shibuya, H., Katz, M. L., Lubahn, D. B., & Johnson, G. S. (1998). A polymorphic (GA)n microsatellite in an intron of the canine endothelin-B receptor gene. Anim Genet, 29(3), 236.

Liu, P. C., Chen, Y. W., Shibuya, H., Katz, M. L., Lubahn, D. B., & Johnson, G. S. (1998). Length polymorphism in a CT-rich microsatellite in an intron of the canine tyrosinase-related protein-2 gene. Anim Genet, 29(4), 327.

Liu, P. C., Chen, Y. W., Shibuya, H., Lubahn, D. B., & Johnson, G. S. (1998). A length polymorphism in an intron of the canine polycystic kidney disease 1 gene. Anim Genet, 29(4), 322-323.

Liu, P. C., Shibuya, H., Katz, M. L., & Johnson, G. S. (1998). A BsmFI PCR/RFLP in the canine CD19 gene. Anim Genet, 29(1), 64-65.

Liu, P. C., Shibuya, H., Lubahn, D. B., & Johnson, G. S. (1998). A polymorphic (CT)n microsatellite in an intron of the canine SA-hypertension gene. Anim Genet, 29(1), 72.

Liu, P. C., Shibuya, H., Nonneman, D., Katz, M. L., & Johnson, G. S. (1998). A BseRI PCR/RFLP in an intron of the canine phenol sulfotransferase gene. Anim Genet, 29(4), 329.

Shibuya, H., Cassells, M. W., Huang, T. H., & Johnson, G. S. (1998). A polymorphic (TG)n microsatellite in an intron of the canine angiotensin I converting enzyme gene. Anim Genet, 29(1), 66-67.

Shibuya, H., Liu, P. C., Katz, M. L., Siakotos, A. N., Nonneman, D. J., & Johnson, G. S. (1998). Coding sequence and exon/intron organization of the canine CLN3 (batten disease) gene and its exclusion as the locus for ceroid?lipofuscinosis in english setter dogs. J Neurosci Res, 52(3), 268-275.

Shibuya, H., Liu, P. C., O'Brien, D. P., Chen, Y. W., & Johnson, G. S. (1998). A BbvI mismatch PCR/RFLP marker for the canine huntingtin gene. Anim Genet, 29(3), 239-240.

Stoy, S. J., Shibuya, H., O'Brien, D., & Johnson, G. S. (1998). A BsII PCR/RFLP in the renin binding protein (RnBP) gene on canine chromosome X. Anim Genet, 29(4), 327-328.

Zhou, T., Nonneman, D., Shibuya, H., Khan, S., Liu, P. C., & Johnson, G. S. (1998). An AvaII PCR/RFLP in an exon of the canine gene for the beta subunit of the amiloride-sensitive sodium channel (SCNN1B). Anim Genet, 29(3), 239.

Zhou, T., Shibuya, H., Liu, P. C., O'Brien, D. P., & Johnson, G. S. (1998). A NlaIII PCR/RFLP in an intron of the retinitis pigmentosa GTPase regulator gene (RPGR) on the canine X chromosome. Anim Genet, 29(4), 330-331.

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