Peer-Reviewed Publications Resulting from CHF-funded Grants

We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research.  By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.

You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.

To browse publications by year you may also wish to view our Impact Report.

Research Program Area
Breed:
Disease:
 
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Grant Number: 02111-A

Research Program Area: Dermatology and Allergic Disease

Evaluating the Contribution of Fungal Infection to the Pathogenesis of Atopic Dermatitis: Putting Evidence under the Use of Antifungal Medication

Meason-Smith, C., Diesel, A., Patterson, A. P., Older, C. E., Mansell, J. M., Suchodolski, J. S., & Rodrigues Hoffmann, A. (2015). What is living on your dog’s skin? Characterization of the canine cutaneous mycobiota and fungal dysbiosis in canine allergic dermatitis. FEMS Microbiology Ecology, 91(12), fiv139. https://doi.org/10.1093/femsec/fiv139

Grant Number: 02187-MOU

Research Program Area: Immunology and Infectious Disease

Investigating Symmetrical Lupoid Onychodystrophy in Bearded Collies

Gershony, L. C., Belanger, J. M., Short, A. D., Le, M., Hytönen, M. K., Lohi, H., … Oberbauer, A. M. (2019). DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds. Canine Genetics and Epidemiology, 6(1), 2. https://doi.org/10.1186/s40575-019-0070-7

Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2019). Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie. Genes, 10(9), 635. doi.org/10.3390/genes10090635

Grant Number: 02192-A

Research Program Area: Reproductive Conditions

Advanced Semen Analysis in Labrador Retrievers

Fuente-Lara, A. de la, Hesser, A., Christensen, B., Gonzales, K., & Meyers, S. (2019). Effects from aging on semen quality of fresh and cryopreserved semen in Labrador Retrievers. Theriogenology. https://doi.org/10.1016/j.theriogenology.2019.04.013

Hesser, A., Darr, C., Gonzales, K., Power, H., Scanlan, T., Thompson, J., … Meyers, S. (2017). Semen evaluation and fertility assessment in a purebred dog breeding facility. Theriogenology, 87, 115–123. https://doi.org/10.1016/j.theriogenology.2016.08.012

 

Grant Number: 02388-MOU

Research Program Area: Cardiology

Genetic Markers for Familial Subvalvular Aortic Stenosis in Newfoundlands
Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052

Grant Number: 02066

Research Program Area: Kidney & Urological Disease

Identification of Novel Biomarkers and Therapeutic Targets for Chronic Kidney Disease in Dogs

Hokamp, J. A., Cianciolo, R. E., Boggess, M., Lees, G. E., Benali, S. L., Kovarsky, M., & Nabity, M. B. (2016). Correlation of Urine and Serum Biomarkers with Renal Damage and Survival in Dogs with Naturally Occurring Proteinuric Chronic Kidney Disease. J Vet Intern Med, 30(2), 591-601. doi:10.1111/jvim.13832

Chu, C. P., & Nabity, M. B. (2019). Comparison of RNA isolation and library preparation methods for small RNA sequencing of canine biofluids. Veterinary Clinical Pathology, 0(0). https://doi.org/10.1111/vcp.12743

Grant Number: 02424

Research Program Area: Cardiology

Identification of Genetic Variants Associated with Pulmonary Valve Stenosis in Bulldogs through Whole-Genome Sequencing

Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052

Grant Number: 02267-A

Research Program Area: Reproductive Conditions

An Epidemiological Study of Brucella canis

Whitten, T. V., Brayshaw, G., Patnayak, D., Alvarez, J., Larson, C. M., Root Kustritz, M., … Scheftel, J. M. (2019). Seroprevalence of Brucella canis Antibodies in Dogs Entering a Minnesota Humane Society, Minnesota, 2016–2017. Preventive Veterinary Medicine. https://doi.org/10.1016/j.prevetmed.2019.04.015


Grant Number: 02488

Research Program Area: Endocrinology

Addison's Disease and Symmetrical Lupoid Onychodystrophy in Bearded Collies Provide Common Ground for Identifying Susceptibility Loci Underlying Canine Autoimmune Disorders
Gershony, L. C., Belanger, J. M., Short, A. D., Le, M., Hytönen, M. K., Lohi, H., … Oberbauer, A. M. (2019). DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds. Canine Genetics and Epidemiology, 6(1), 2. https://doi.org/10.1186/s40575-019-0070-7

Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2019). Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie. Genes, 10(9), 635. doi.org/10.3390/genes10090635

Grant Number: 00572-A

Research Program Area: Dermatology and Allergic Disease

Heritability of Atopic Dermatitis in West Highland White Terriers
Agler, C. S., Friedenberg, S., Olivry, T., Meurs, K. M., & Olby, N. J. (2019). Genome-wide association analysis in West Highland White Terriers with atopic dermatitis. Veterinary Immunology and Immunopathology, 209, 1–6. https://doi.org/10.1016/j.vetimm.2019.01.004
 
Wong, A. K., Ruhe, A. L., Dumont, B. L., Robertson, K. R., Guerrero, G., Shull, S. M., … Neff, M. W. (2010). A Comprehensive Linkage Map of the Dog Genome. Genetics, 184(2), 595–605. https://doi.org/10.1534/genetics.109.106831

Grant Number: 01426

Research Program Area: Oncology

Personalized Medicine for the Treatment of Canine Mast Cell Tumors
Halsey, C. H. C., Thamm, D. H., Weishaar, K. M., Burton, J. H., Charles, J. B., Gustafson, D. L., … Ehrhart, E. J. (2017). Expression of Phosphorylated KIT in Canine Mast Cell Tumor. Veterinary Pathology, 54(3), 387–394. https://doi.org/10.1177/0300985816688943

Thamm, D. H., Weishaar, K. M., Charles, J. B., & Ehrhart, E. J. (2019, July 31). Phosphorylated KIT as a Predictor of Outcome in Canine Mast Cell Tumours Treated with Toceranib Phosphate or Vinblastine. https://doi.org/10.1111/vco.12525

Weishaar, K. M., Ehrhart, E. J., Avery, A. C., Charles, J. B., Elmslie, R. E., Vail, D. M., … Thamm, D. H. (2018). c-Kit Mutation and Localization Status as Response Predictors in Mast Cell Tumors in Dogs Treated with Prednisone and Toceranib or Vinblastine. Journal of Veterinary Internal Medicine, 32(1), 394–405. https://doi.org/10.1111/jvim.14889

Grant Number: 02520-MOU

Research Program Area: Cardiology

Identification of Genetic Markers for Familial Subvalvular Aortic Stenosis in Rottweilers

Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052

Grant Number: 02380-A

Research Program Area: Immunology and Infectious Disease

Estimating Prevalence and Identifying Risk Factors for Canine Leptospirosis in North America

-Leptospirosis Information for Dog Owners

Smith, A. M., Arruda, A. G., Evason, M. D., Weese, J. S., Wittum, T. E., Szlosek, D., & Stull, J. W. (2019). A cross-sectional study of environmental, dog, and human-related risk factors for positive canine leptospirosis PCR test results in the United States, 2009 to 2016. BMC Veterinary Research, 15(1), 412. doi.org/10.1186/s12917-019-2148-6

Grant Number: 02252

Research Program Area: Neurology, Epilepsy Initiative

Investigating a Ketogenic Medium-Chain Triglyceride (MCT) Supplement for the Treatment of Drug-Resistant Canine Idiopathic Epilepsy and Its Behavioral Comorbidities

Packer, R. M. A., Volk, H. A., & Fowkes, R. C. (2017). Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers. Physiology & Behavior, 177, 27–33. https://doi.org/10.1016/j.physbeh.2017.04.008

Berk, B. A., Packer, R. M., Law, T., & Volk, H. A. (2018). Investigating owner use of dietary supplements in dogs with idiopathic epilepsy. Research in Veterinary Science. 119, 276-284.  doi: 10.1016/j.rvsc.2018.07.004

Berk, B. A., Packer, R. M. A., Law, T. H., Wessmann, A., Bathen-Nöthen, A., Jokinen, T. S., … Volk, H. A. (2019). A double-blinded randomised dietary supplement crossover trial design to investigate the short-term influence of medium chain fatty acid (MCT) supplement on canine idiopathic epilepsy: study protocol. BMC Veterinary Research, 15(1), 181. https://doi.org/10.1186/s12917-019-1915-8

Grant Number: 02521-MOU

Research Program Area: Cardiology

Identification of Genetic Markers for Familial Subvalvular Aortic Stenosis in Golden Retrievers

Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052

Grant Number: 01660

Research Program Area: Oncology - Osteosarcoma

Identifying the Genes That Confer Risk for Osteosarcoma
Alvarez, C. E. (2014). Naturally Occurring Cancers in Dogs: Insights for Translational Genetics and Medicine. ILAR Journal, 55(1), 16–45. https://doi.org/10.1093/ilar/ilu010

Clemente-Vicario, F., Alvarez, C. E., Rowell, J. L., Roy, S., London, C. A., Kisseberth, W. C., & Lorch, G. (2015). Human Genetic Relevance and Potent Antitumor Activity of Heat Shock Protein 90 Inhibition in Canine Lung Adenocarcinoma Cell Lines. PLOS ONE, 10(11), e0142007. https://doi.org/10.1371/journal.pone.0142007

Lutful Kabir, F. M., Alvarez, C. E., & Bird, R. C. (2015). Canine Mammary Carcinomas: A Comparative Analysis of Altered Gene Expression. Veterinary Sciences, 3(1). https://doi.org/10.3390/vetsci3010001

Zaldívar-López, S., Rowell, J. L., Fiala, E. M., Zapata, I., Couto, C. G., & Alvarez, C. E. (2017). Comparative genomics of canine hemoglobin genes reveals primacy of beta subunit delta in adult carnivores. BMC Genomics, 18(1). https://doi.org/10.1186/s12864-017-3513-0

Zapata, I., Moraes, L. E., Fiala, E. M., Zaldivar-Lopez, S., Couto, C. G., Rowell, J. L., & Alvarez, C. E. (2019). Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common. BMC Genomics, 20(1), 226. https://doi.org/10.1186/s12864-019-5531-6

Zapata, I., Serpell, J. A., & Alvarez, C. E. (2016). Genetic mapping of canine fear and aggression. BMC Genomics, 17(1). https://doi.org/10.1186/s12864-016-2936-3

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Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

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Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

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