Peer-Reviewed Publications Resulting from CHF-funded Grants

We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research.  By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.

You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.

To browse publications by year you may also wish to view our Impact Report.

Research Program Area
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Grant Number: 02111-A

Research Program Area: Dermatology and Allergic Disease

Evaluating the Contribution of Fungal Infection to the Pathogenesis of Atopic Dermatitis: Putting Evidence under the Use of Antifungal Medication

Meason-Smith, C., Diesel, A., Patterson, A. P., Older, C. E., Mansell, J. M., Suchodolski, J. S., & Rodrigues Hoffmann, A. (2015). What is living on your dog’s skin? Characterization of the canine cutaneous mycobiota and fungal dysbiosis in canine allergic dermatitis. FEMS Microbiology Ecology, 91(12), fiv139. https://doi.org/10.1093/femsec/fiv139

Grant Number: 02529

Research Program Area: General Canine Health

Understanding the Genetics of Adverse Drug Reactions in Sighthounds: Phase II
Mealey, K. L., Martinez, S. E., Villarino, N. F., & Court, M. H. (2019). Personalized medicine: going to the dogs? Human Genetics. https://doi.org/10.1007/s00439-019-02020-w

Martinez, S. E., Shi, J., Zhu, H.-J., Jimenez, T. E. P., Zhu, Z., & Court, M. H. (2019). Absolute quantitation of drug metabolizing cytochrome P450 enzymes and accessory proteins in dog liver microsomes using label-free standard-free analysis reveals inter-breed variability. Drug Metabolism and Disposition, dmd.119.088070. https://doi.org/10.1124/dmd.119.088070

Martinez, S. E., Andresen, M. C., Zhu, Z., Papageorgiou, I., & Court, M. H. (2020). Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization. Scientific Reports, 10(69). doi:10.1038/s41598-019-56660-z

Grant Number: 2242

Research Program Area: General Canine Health

Understanding the Genetics of Adverse Drug Reactions in Sighthounds
Martinez, S. E., Pandey, A. V., & Court, M. H. (2019). Isoform-Dependent Effects of Cytochrome P450 Oxidoreductase Polymorphisms on Drug Metabolism by Cytochrome P450 Enzymes in Dogs. The FASEB Journal, 33(1_supplement), 506.9-506.9. https://doi.org/10.1096/fasebj.2019.33.1_supplement.506.9

Martinez, S. E., Shi, J., Zhu, H.-J., Jimenez, T. E. P., Zhu, Z., & Court, M. H. (2019). Absolute quantitation of drug metabolizing cytochrome P450 enzymes and accessory proteins in dog liver microsomes using label-free standard-free analysis reveals inter-breed variability. Drug Metabolism and Disposition, dmd.119.088070. https://doi.org/10.1124/dmd.119.088070

Martinez, S. E., Andresen, M. C., Zhu, Z., Papageorgiou, I., & Court, M. H. (2020). Pharmacogenomics of poor drug metabolism in Greyhounds: Cytochrome P450 (CYP) 2B11 genetic variation, breed distribution, and functional characterization. Scientific Reports, 10(69). doi:10.1038/s41598-019-56660-z

Grant Number: 2287

Research Program Area: Tick-Borne Disease Initiative

Enhanced Testing for the Diagnosis of Bartonellosis in Dogs

Neupane, P., Hegarty, B. C., Marr, H. S., Maggi, R. G., Birkenheuer, A. J., & Breitschwerdt, E. B. (2018). Evaluation of cell culture-grown Bartonella antigens in immunofluorescent antibody assays for the serological diagnosis of bartonellosis in dogs. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15301

Neupane, P., Sevala, S., Balakrishnan, N., Marr, H., Wilson, J., Maggi, R., Birkenheuer, A., Lappin, M., Chomel, B., & Breitschwerdt, E. B. (2020). Validation of Bartonella henselae Western Immunoblotting for Serodiagnosis of Bartonelloses in Dogs. Journal of Clinical Microbiology.https://doi.org/10.1128/JCM.01335-19

Grant Number: 02519

Research Program Area: Oncology - Hemangiosarcoma

Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas within and between Geographic Locations
Lashnits, E., Neupane, P., Bradley, J. M., Richardson, T., Thomas, R., Linder, K. E., Breen, M., Maggi, R. G., & Breitschwerdt, E. B. (2020). Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States. PLOS ONE, 15(1), e0227234. https://doi.org/10.1371/journal.pone.0227234

Grant Number: 02487

Research Program Area: Oncology

OX40 Checkpoint Molecule Targeted Antibodies for Cancer Immunotherapy in Dogs

Dow, S. (2020). A Role for Dogs in Advancing Cancer Immunotherapy Research. Frontiers in Immunology, 10. https://doi.org/10.3389/fimmu.2019.02935

Grant Number: 01075-A

Research Program Area: Dermatology and Allergic Disease

Description and Characterization of a Hair Coat Disorder in Schipperkes

May, E. R., Frank, L. A., & Sula, M.-J. M. (2019). Description and characterization of a hair coat disorder in schipperkes. Veterinary Dermatology, 30(1), 36-e10. https://doi.org/10.1111/vde.12711

Grant Number: 01986

Research Program Area: Hepatic Disease

Profiling the Metabolic and Lipid Imbalances that are Causative of Gallbladder Disease in Dogs

Aicher, K., Cullen, J., Gookin, J., Seiler, G., Lunn, K., Mathews, K., & Correa, M. (2016). HP02 Association of gallbladder mucocele formation with occult hypothyroidism in dogs: A matched case-controlled study. Journal of Veterinary Internal Medicine. 40(4), 1407-1519. https://doi.org/10.1111/jvim.13952

Aicher, K. M., Cullen, J. M., Seiler, G. S., Lunn, K. F., Mathews, K. G., & Gookin, J. L. (2019). Investigation of adrenal and thyroid gland dysfunction in dogs with ultrasonographic diagnosis of gallbladder mucocele formation. PLOS ONE, 14(2), e0212638. https://doi.org/10.1371/journal.pone.0212638

Gookin, J. L., Correa, M. T., Peters, A., Malueg, A., Mathews, K. G., Cullen, J., & Seiler, G. (2015). Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study. Journal of Veterinary Internal Medicine, 29(6), 1464-1472. https://doi.org/10.1111/jvim.13649

Gookin, J. L., Mathews, K. G., Cullen, J., & Seiler, G. (2018). Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation. PLOS ONE, 13(1), e0191076. https://doi.org/10.1371/journal.pone.0191076

Grant Number: 02322

Research Program Area: General Canine Health

Analysis of the Health, Behavioral, and Longevity Data Collected in the 9/11 Medical Surveillance Longitudinal Study

New article:

Surveillance of Search Dogs | Breeding Better Dogs. (2019). Retrieved November 4, 2019, from https://breedingbetterdogs.com/article/surveillance-search-dogs

Grant Number: 02241

Research Program Area: Dermatology and Allergic Disease

The City Dog Study: Dermatologic and Respiratory Disease among Inner-City Dogs Living in the Homes of Children with Asthma

Exum NG, Olórtegui MP, Yori PP, et al. (2016). Floors and Toilets: Association of Floors and Sanitation Practices with Fecal Contamination in Peruvian Amazon Peri-Urban Households. Environ Sci Technol. 50 (14):7373-7381. doi:10.1021/acs.est.6b01283.

Tsou, P.-Y., McCormack, M. C., Matsui, E. C., Peng, R. D., Diette, G. B., Hansel, N. N., & Davis, M. F. (2019). The Effect of Dog Allergen Exposure on Asthma Morbidity among Inner-city Children with Asthma. Pediatric Allergy and Immunology, 0(ja). https://doi.org/10.1111/pai.13144

Grant Number: 01131

Research Program Area: Oncology - Hemangiosarcoma

Genetic Background and the Angiogenic Phenotype in Cancer

Borgatti, A. (2014). Binding of VEGF-A to canine cancer cells with preferential expression of VEGFR1. Veterinary World, 7(1), 1–6. https://doi.org/10.14202/vetworld.2014.1-6

Gorden, B. H., Kim, J.-H., Sarver, A. L., Frantz, A. M., Breen, M., Lindblad-Toh, K., … Dickerson, E. B. (2014). Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization. The American Journal of Pathology, 184(4), 985–995. https://doi.org/10.1016/j.ajpath.2013.12.025

Kim, J.-H., Frantz, A. M., Sarver, A. L., Gorden Klukas, B. H., Lewellen, M., O’Brien, T. D., … Modiano, J. F. (2018). Modulation of fatty acid metabolism and immune suppression are features of in vitro tumour sphere formation in ontogenetically distinct dog cancers. Veterinary and Comparative Oncology, 16(1), E176–E184. https://doi.org/10.1111/vco.12368

Kim, Jong-Hyuk, Frantz, A. M., Anderson, K. L., Graef, A. J., Scott, M. C., Robinson, S., … Modiano, J. F. (2014). Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment. Experimental Cell Research, 323(1), 155–164. https://doi.org/10.1016/j.yexcr.2014.02.020

Koopmeiners, J. S., & Modiano, J. (2014). A Bayesian adaptive Phase I-II clinical trial for evaluating efficacy and toxicity with delayed outcomes. Clinical Trials (London, England), 11(1), 38–48. https://doi.org/10.1177/1740774513500589

Rinz, C. J., Levine, J., Minor, K. M., Humphries, H. D., Lara, R., Starr-Moss, A. N., … Clark, L. A. (2014). A COLQ Missense Mutation in Labrador Retrievers Having Congenital Myasthenic Syndrome. PLoS ONE, 9(8), e106425. https://doi.org/10.1371/journal.pone.0106425

Schappa, J. T., Frantz, A. M., Gorden, B. H., Dickerson, E. B., Vallera, D. A., & Modiano, J. F. (2013). Hemangiosarcoma and its cancer stem cell subpopulation are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors: Bispecific ligand-targeted toxins. International Journal of Cancer, 133(8), 1936–1944. https://doi.org/10.1002/ijc.28187

Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922

Megquier, K., Turner-Maier, J., Swofford, R., Kim, J.-H., Sarver, A. L., Wang, C., … Lindblad-Toh, K. (2019). Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma. Molecular Cancer Research, 17(12), 2410–2421 https://doi.org/10.1158/1541-7786.MCR-19-0221

Grant Number: 02204-T

Research Program Area: Oncology

Using Enhanced Imaging to Evaluate Tumor Margins for Canine Mammary Cancer and Soft Tissue Sarcoma

Mesa, K. J., Selmic, L. E., Pande, P., Monroy, G. L., Reagan, J., Samuelson, J., … Boppart, S. A. (2017). Intraoperative optical coherence tomography for soft tissue sarcoma differentiation and margin identification. Lasers in Surgery and Medicine, 49(3), 240–248. https://doi.org/10.1002/lsm.22633

Selmic, L. E., Samuelson, J., Reagan, J. K., Mesa, K. J., Driskell, E., Li, J., … Boppart, S. A. (2018). Intraoperative imaging of surgical margins of canine soft tissue sarcoma using optical coherence tomography. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12448

Holt, D., Singhal, S., & Selmic, L. E. (2019). Near‐infrared imaging and optical coherence tomography for intraoperative visualization of tumors. Veterinary Surgery, 1–11. https://doi.org/10.1111/vsu.13332

Grant Number: 01557

Research Program Area: Oncology

Narrowing the Search for the Genetic Basis of Histiocytic Malignancies

Kennedy, K., Thomas, R., & Breen, M. (2016). Canine Histiocytic Malignancies—Challenges and Opportunities. Veterinary Sciences, 3(1), 2. https://doi.org/10.3390/vetsci3010002

Kennedy, K., Thomas, R., Durrant, J., Jiang, T., Motsinger-Reif, A., & Breen, M. (2019). Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex. Chromosome Research. https://doi.org/10.1007/s10577-019-09606-0

Grant Number: 01896-A

Research Program Area: Epilepsy Initiative

A Pilot Study: Establishing the Role of Melatonin in the Occurrence of Seizures in Dogs

Thomovsky, S. A., Chen, A. V., Deavila, D. M., & Kiszonas, A. M. (2019). Serum Melatonin Values in Normal Dogs and Dogs with Seizures. Journal of the American Animal Hospital Association. https://doi.org/10.5326/JAAHA-MS-6669

Grant Number: 02436

Research Program Area: Cardiology

Predicting Disease Stage and Diuretic Responsiveness in Dogs with Acquired Heart Disease

Adin, D., Kurtz, K., Atkins, C., Papich, M. G., & Vaden, S. (2019). Role of electrolyte concentrations and renin-angiotensin-aldosterone activation in the staging of canine heart disease. Journal of Veterinary Internal Medicine, 1–12. https://doi.org/10.1111/jvim.15662

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Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

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