Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
|
Grant Number: 2336 Research Program Area: Ophthalmology |
Genetics of Primary Angle Closure Glaucoma in American Cocker Spaniels None at this time. |
|
Grant Number: 02404-A Research Program Area: Immunology and Infectious Disease |
The Impact of Lidocaine Administration on Natural Killer Cell Populations in Canine Sepsis None at this time. |
|
Grant Number: 02404-A Research Program Area: Immunology and Infectious Disease |
The Impact of Lidocaine Administration on Natural Killer Cell Populations in Canine Sepsis None at this time. |
|
Grant Number: 2336 Research Program Area: Ophthalmology |
Genetics of Primary Angle Closure Glaucoma in American Cocker Spaniels None at this time. |
|
Grant Number: 02157-MOU Research Program Area: Neurology |
Genomics of Deafness in the Dalmatian Haase, B., Willet, C. E., Chew, T., Samaha, G., Child, G., & Wade, C. M. (2022). De-novo and genome-wide meta-analyses identify a risk haplotype for congenital sensorineural deafness in Dalmatian dogs. Scientific Reports, 12(1), 15439. https://doi.org/10.1038/s41598-022-19535-4 Brancalion, L., Haase, B., Mazrier, H., Willet, C. E., Lindblad‐Toh, K., Lingaas, F., & Wade, C. M. (2021). Roan, ticked and clear coat patterns in the canine are associated with three haplotypes near usherin on CFA38. Animal Genetics. https://doi.org/10.1111/age.13040 Brancalion, L., Haase, B., Willet, C. E., & Wade, C. M. (2021). Sequence variants of the canine melanocyte inducing transcription factor (MITF) locus reveal a common MITF-A processed pseudogene. Animal Genetics, 52(5), 777–778. https://doi.org/10.1111/age.13106 |
|
Grant Number: 2015 Research Program Area: Epilepsy Initiative |
Development of a Genetic Marker for Idiopathic Epilepsy in the Belgian Tervuren and Belgian Sheepdog Belanger, J. M., Heinonen, T., Famula, T. R., Mandigers, P. J. J., Leegwater, P. A., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2022). Validation of a Chromosome 14 Risk Haplotype for Idiopathic Epilepsy in the Belgian Shepherd Dog Found to Be Associated with an Insertion in the RAPGEF5 Gene. Genes, 13(7), 1124. https://doi.org/10.3390/genes13071124 Belanger, J. M., Famula, T. R., Gershony, L. C., Palij, M. K., & Oberbauer, A. M. (2020). Genome-wide association analysis of idiopathic epilepsy in the Belgian Shepherd. Canine Medicine and Genetics, 7(1), 12. https://doi.org/10.1186/s40575-020-00091-x Oberbauer, A. M. (2003). The Genetics of Epilepsy in the Belgian Tervuren and Sheepdog. Journal of Heredity, 94(1), 57–63. https://doi.org/10.1093/jhered/esg010 Oberbauer, Anita M., Belanger, J. M., Grossman, D. I., Regan, K. R., & Famula, T. R. (2010). Genome-wide linkage scan for loci associated with epilepsy in Belgian Shepherd Dogs. BMC Genetics, 11, 35. https://doi.org/10.1186/1471-2156-11-35 |
|
Grant Number: 02252 Research Program Area: Epilepsy Initiative |
Investigating a Ketogenic Medium-Chain Triglyceride (MCT) Supplement for the Treatment of Drug-Resistant Canine Idiopathic Epilepsy and Its Behavioral Comorbidities Berk, B. A., Ottka, C., Hong Law, T., Packer, R. M. A., Wessmann, A., Bathen-Nöthen, A., Jokinen, T. S., Knebel, A., Tipold, A., Lohi, H., & Volk, H. A. (2022). Metabolic fingerprinting of dogs with idiopathic epilepsy receiving a ketogenic medium-chain triglyceride (MCT) oil. Frontiers in Veterinary Science, 9. https://www.frontiersin.org/articles/10.3389/fvets.2022.935430 Berk, B. A., Packer, R. M.-A., Fritz, J., & Volk, H. A. (2022). Oral Palatability Testing of a Medium-Chain Triglyceride Oil Supplement (MCT) in a Cohort of Healthy Dogs in a Non-Clinical Setting. Animals, 12(13), 1639. https://doi.org/10.3390/ani12131639 Berk, B. A., Packer, R. M. A., Law, T. H., Wessmann, A., Bathen-Nöthen, A., Jokinen, T. S., Knebel, A., Tipold, A., Pelligand, L., & Volk, H. A. (2020). Medium-chain triglycerides dietary supplement improves cognitive abilities in canine epilepsy. Epilepsy & Behavior. https://doi.org/10.1016/j.yebeh.2020.107608
Berk, B. A., Law, T. H., Packer, R. M. A., Wessmann, A., Bathen‐Nöthen, A., Jokinen, T. S., Knebel, A., Tipold, A., Pelligand, L., Meads, Z., & Volk, H. A. (2020). A multicenter randomized controlled trial of effect of medium-chain triglyceride dietary supplementation on epilepsy in dogs. Journal of Veterinary Internal Medicine, 1–2. https://doi.org/10.1111/jvim.15756
Berk, B. A., Packer, R. M. A., Law, T. H., Wessmann, A., Bathen-Nöthen, A., Jokinen, T. S., … Volk, H. A. (2019). A double-blinded randomised dietary supplement crossover trial design to investigate the short-term influence of medium chain fatty acid (MCT) supplement on canine idiopathic epilepsy: study protocol. BMC Veterinary Research, 15(1), 181. https://doi.org/10.1186/s12917-019-1915-8
Watson, F., Packer, R. M. A., Rusbridge, C., & Volk, H. A. (2019). Behavioural changes in dogs with idiopathic epilepsy. Veterinary Record. https://doi.org/10.1136/vr.105222
Berk, B. A., Packer, R. M. A., Law, T. H., & Volk, H. A. (2018). Investigating owner use of dietary supplements in dogs with idiopathic epilepsy. Research in Veterinary Science, 119, 276–284. https://doi.org/10.1016/j.rvsc.2018.07.004
Packer, R. M. A., Volk, H. A., & Fowkes, R. C. (2017). Physiological reactivity to spontaneously occurring seizure activity in dogs with epilepsy and their carers. Physiology & Behavior, 177, 27–33. https://doi.org/10.1016/j.physbeh.2017.04.008
|
|
Grant Number: 02806-MOU Research Program Area: Oncology - Hemangiosarcoma |
Strategic Prevention of Canine Hemangiosarcoma: Lifetime Follow-Up Sarver, A. L., Makielski, K. M., DePauw, T. A., Schulte, A. J., & Modiano, J. F. (2022). Increased risk of cancer in dogs and humans: A consequence of recent extension of lifespan beyond evolutionarily determined limitations? Aging and Cancer. https://doi.org/10.1002/aac2.12046 |
|
Grant Number: 1613 Research Program Area: Epilepsy Initiative |
Development of a Genetic Marker for Idiopathic Epilepsy in the Belgian Tervuren and Belgian Sheepdog Belanger, J. M., Heinonen, T., Famula, T. R., Mandigers, P. J. J., Leegwater, P. A., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2022). Validation of a Chromosome 14 Risk Haplotype for Idiopathic Epilepsy in the Belgian Shepherd Dog Found to Be Associated with an Insertion in the RAPGEF5 Gene. Genes, 13(7), 1124. https://doi.org/10.3390/genes13071124 Belanger, J. M., Famula, T. R., Gershony, L. C., Palij, M. K., & Oberbauer, A. M. (2020). Genome-wide association analysis of idiopathic epilepsy in the Belgian Shepherd. Canine Medicine and Genetics, 7(1), 12. https://doi.org/10.1186/s40575-020-00091-x Oberbauer, A. M. (2003). The Genetics of Epilepsy in the Belgian Tervuren and Sheepdog. Journal of Heredity, 94(1), 57–63. https://doi.org/10.1093/jhered/esg010 Oberbauer, Anita M., Belanger, J. M., Grossman, D. I., Regan, K. R., & Famula, T. R. (2010). Genome-wide linkage scan for loci associated with epilepsy in Belgian Shepherd Dogs. BMC Genetics, 11, 35. https://doi.org/10.1186/1471-2156-11-35 |
|
Grant Number: 02669-A Research Program Area: Reproductive Conditions |
Lipid Composition and Lipid Droplet Dynamics in Canine Pyometra Affected Endometria Leitner, N., Hlavaty, J., Heider, S., Ertl, R., Gabriel, C., & Walter, I. (2022). Lipid droplet dynamics in healthy and pyometra-affected canine endometrium. BMC Veterinary Research, 18(1), 221. https://doi.org/10.1186/s12917-022-03321-5 |
|
Grant Number: 02553 Research Program Area: Tick-Borne Disease Initiative |
Targeted Next Generation Sequencing Panel for Comprehensive Testing of Vector-borne Pathogens
Kattoor, J. J., Nikolai, E., Qurollo, B., & Wilkes, R. P. (2022). Targeted Next-Generation Sequencing for Comprehensive Testing for Selected Vector-Borne Pathogens in Canines. Pathogens, 11(9), 964. https://doi.org/10.3390/pathogens11090964 |
|
Grant Number: 02838 Research Program Area: Immunology and Infectious Disease |
Standardization of rLiNTPDase2 and Derived Chimeras as Antigens on Immunochromatographic Assay for Diagnosis of Canine Visceral Leishmaniasis Castro RB, Badaró de Moraes JV, de Souza ACA, Favarato ES, Voorwald FA, Dos Santos FM, Bressan GC, Vasconcellos RS, Fietto JLR. High-resolution mapping of linear epitopes from LiNTPDase2: Advancing leishmaniasis detection using optimized protein and peptide antigens. Diagn Microbiol Infect Dis. 2024 Jul 18;110(2):116448. doi: 10.1016/j.diagmicrobio.2024.116448. Epub ahead of print. PMID: 39029390. de Castro, R. B., de Souza, A. C. A., Pavione, N. da R. T., de Moraes, J. V. B., Ribeiro, I. C., de Melo Agripino, J., Bressan, G. C., de Souza Vasconcellos, R., Silva-Júnior, A., & Fietto, J. L. R. (2022). Urea, salts, and Tween 20 influence on adsorption of IgG and Leishmania rNTPDase2 to nitrocellulose. Analytical Biochemistry, 114648. https://doi.org/10.1016/j.ab.2022.114648 |
|
Grant Number: 02452-A Research Program Area: Neurology |
Targeting the T helper Inflammatory Pathway in Meningoencephalomyelitis of Unknown Origin (MUO) Barber, R., & Barber, J. (2022). Differential T-cell responses in dogs with meningoencephalomyelitis of unknown origin compared to healthy controls. Frontiers in Veterinary Science, 9. https://www.frontiersin.org/articles/10.3389/fvets.2022.925770 |
|
Grant Number: 01844 Research Program Area: Kidney & Urological Disease |
Treatment of Urinary Incontinence with Multipotent Muscle Cells: A Regenerative Medicine Approach to a Common Canine Health Problem Vaden, S. L., Mathews, K. G., Yoo, J., Williams, J. K., Harris, T., Secoura, P., Robertson, J., Gleason, K. L., Reynolds, H., & Piedrahita, J. (2022). The use of autologous skeletal muscle progenitor cells for adjunctive treatment of presumptive urethral sphincter mechanism incompetence in female dogs. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16505 Vaden, S. L., & Elliott, J. (2016). Management of Proteinuria in Dogs and Cats with Chronic Kidney Disease. Vet Clin North Am Small Anim Pract, 46(6), 1115-1130. doi:10.1016/j.cvsm.2016.06.009 |
|
Grant Number: 02821-A Research Program Area: Immunology and Infectious Disease |
Investigating the Role of Aedes aegypti in Dog Heartworm Transmission in Communities along the U.S.-Mexico Border Scavo, N. A., Zecca, I. B., Sobotyk, C., Saleh, M. N., Lane, S. K., Olson, M. F., Hamer, S. A., Verocai, G. G., & Hamer, G. L. (2022). High prevalence of canine heartworm, Dirofilaria immitis, in pet dogs in south Texas, USA, with evidence of Aedes aegypti mosquitoes contributing to transmission. Parasites & Vectors, 15(1), 407. https://doi.org/10.1186/s13071-022-05514-1 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
