Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 01336A Research Program Area: Oncology |
Finding the Mutations that Increase Susceptibility to Transitional Cell Carcinoma in the Scottish Terrier, West Highland Terrier, and Shetland Sheepdog Parker, H. G., Dhawan, D., Harris, A. C., Ramos-Vara, J. A., Davis, B. W., Knapp, D. W., & Ostrander, E. A. (2020). RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors BMC Cancer, 20(251). doi.org/10.1186/s12885-020-06737-0
Parker, H. G., Shearin, A. L., & Ostrander, E. A. (2010). Man’s Best Friend Becomes Biology’s Best in Show: Genome Analyses in the Domestic Dog. Annual Review of Genetics, 44(1), 309–336. https://doi.org/10.1146/annurev-genet-102808-115200 Shearin, A. L., & Ostrander, E. A. (2010). Leading the way: canine models of genomics and disease. Disease Models & Mechanisms, 3(1–2), 27–34. https://doi.org/10.1242/dmm.004358 |
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Grant Number: 02386-A Research Program Area: Tick-Borne Disease Initiative |
Surveillance of Hepatozoon americanum In Populations of the Gulf Coast Tick Vector Parkins, N. D., Stokes, J. V., Gavron, N. A., Frankovich, A. N., & Varela-Stokes, A. S. (2020). Scarcity of Hepatozoon americanum in Gulf Coast tick vectors and potential for cultivating the protozoan. Veterinary Parasitology: Regional Studies and Reports, 21, 100421. https://doi.org/10.1016/j.vprsr.2020.100421 |
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Grant Number: 1445 Research Program Area: Gastrointestinal Disease |
Granulomatous Colitis In Boxer Dogs: Genetic Analysis of Disease and Functional Analysis of Bacterial Killing Manchester, A. C., Dogan, B., Guo, Y., & Simpson, K. W. (2020). Escherichia coli-associated granulomatous colitis in dogs treated according to antimicrobial susceptibility profiling. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15995 Dogan, B., Zhang, S., Kalla, S. E., Dogan, E. I., Guo, C., Ang, C. R., & Simpson, K. W. (2020). Molecular and Phenotypic Characterization of Escherichia coli Associated with Granulomatous Colitis of Boxer Dogs. Antibiotics, 9(9), 540. https://doi.org/10.3390/antibiotics9090540 Hayward, J. J., Castelhano, M. G., Oliveira, K. C., Corey, E., Balkman, C., Baxter, T. L., … Boyko, A. R. (2016). Complex disease and phenotype mapping in the domestic dog. Nature Communications, 7(1). https://doi.org/10.1038/ncomms10460 |
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Grant Number: 02235-A Research Program Area: General Canine Health |
Medical Surveillance of Dogs Deployed to the World Trade Center and the Pentagon on 9/11/01 Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 Surveillance of Search Dogs | Breeding Better Dogs. (2019). Retrieved November 4, 2019, from https://breedingbetterdogs.com/article/surveillance-search-dogs |
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Grant Number: 01828 Research Program Area: Musculoskeletal Conditions and Disease |
Mapping of Genetic Risk Factors for Canine Hip Dysplasia Mikkola, L., Kyöstilä, K., Donner, J., Lappalainen, A. K., Hytönen, M. K., Lohi, H., & Iivanainen, A. (2021). An across-breed validation study of 46 genetic markers in canine hip dysplasia. BMC Genomics, 22(1), 68. https://doi.org/10.1186/s12864-021-07375-x Mikkola, L. I., Holopainen, S., Lappalainen, A. K., Pessa-Morikawa, T., Augustine, T. J. P., Arumilli, M., & Hyt, M. K. (2019). Novel protective and risk loci in hip dysplasia in German Shepherds. PLoS Genetics, 15(7), e1008197. https://doi.org/10.1371/journal.pgen.1008197 Mikkola, L., Holopainen, S., Pessa-Morikawa, T., Lappalainen, A. K., Hytönen, M. K., Lohi, H., & Iivanainen, A. (2019). Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci BMC Genomics, 20(1027), 1–13. doi.org/10.1186/s12864-019-6422-6 |
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Grant Number: 01591 Research Program Area: Dermatology and Allergic Disease |
Identification of the Genes That Confer Risk for Atopic Dermatitis Tengvall, K., Sundström, E., Wang, C. et al. Bayesian model and selection signature analyses reveal risk factors for canine atopic dermatitis. Commun Biol 5, 1348 (2022). https://doi.org/10.1038/s42003-022-04279-8
Agler, C. S., Friedenberg, S., Olivry, T., Meurs, K. M., & Olby, N. J. (2019). Genome-wide association analysis in West Highland White Terriers with atopic dermatitis. Veterinary Immunology and Immunopathology, 209, 1–6. https://doi.org/10.1016/j.vetimm.2019.01.004
Salzmann, C. A., Olivry, T. J., Nielsen, D. M., Paps, J. S., Harris, T. L., & Olby, N. J. (2011). Genome-wide linkage study of atopic dermatitis in West Highland White Terriers. BMC Genetics, 12(1), 37. https://doi.org/10.1186/1471-2156-12-37
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Grant Number: 02267-A Research Program Area: Reproductive Conditions |
An Epidemiological Study of Brucella canis
Whitten, T. V., Brayshaw, G., Patnayak, D., Alvarez, J., Larson, C. M., Root Kustritz, M., … Scheftel, J. M. (2019). Seroprevalence of Brucella canis Antibodies in Dogs Entering a Minnesota Humane Society, Minnesota, 2016–2017. Preventive Veterinary Medicine. https://doi.org/10.1016/j.prevetmed.2019.04.015 |
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Grant Number: 01265 Research Program Area: Immunology and Infectious Disease |
Understanding Mechanisms Involved in Canine Autoimmune and Inflammatory Disorders Jalilian I. (2011).The canine P2X7 receptor. http://ro.uow.edu.au/theses/3458/. - Peranec M. The P2X7 receptor in canine monocytes. BSc (Hons) Thesis, University of Wollongong, 2011. Bartlett, R., Stokes, L., & Sluyter, R. (2014). The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease. Pharmacological Reviews, 66(3), 638–675. https://doi.org/10.1124/pr.113.008003 Jalilian, I., Peranec, M., Curtis, B. L., Seavers, A., Spildrejorde, M., Sluyter, V., & Sluyter, R. (2012). Activation of the damage-associated molecular pattern receptor P2X7 induces interleukin-1β release from canine monocytes. Veterinary Immunology and Immunopathology, 149(1–2), 86–91. https://doi.org/10.1016/j.vetimm.2012.05.004 Jalilian, I., Spildrejorde, M., Seavers, A., Curtis, B. L., McArthur, J. D., & Sluyter, R. (2012). Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells. Veterinary Immunology and Immunopathology, 150(3–4), 228–233. https://doi.org/10.1016/j.vetimm.2012.09.040 Spildrejorde, M., Bartlett, R., Stokes, L., Jalilian, I., Peranec, M., Sluyter, V., … Sluyter, R. (2014). R270C polymorphism leads to loss of function of the canine P2X7 receptor. Physiological Genomics, 46(14), 512–522. https://doi.org/10.1152/physiolgenomics.00195.2013 Wiley, J. S., Sluyter, R., Gu, B. J., Stokes, L., & Fuller, S. J. (2011). The human P2X7 receptor and its role in innate immunity. Tissue Antigens, 78(5), 321–332. https://doi.org/10.1111/j.1399-0039.2011.01780.x Sophocleous, R. A., Sluyter, V., Curtis, B. L., Curtis, S. J., Jurak, L. M., Faulks, M., … Sluyter, R. (2019). Association of a P2RX7 gene missense variant with brachycephalic dog breeds. Animal Genetics. https://doi.org/10.1111/age.12884 |
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Grant Number: 01075-A Research Program Area: Dermatology and Allergic Disease |
Description and Characterization of a Hair Coat Disorder in Schipperkes May, E. R., Frank, L. A., & Sula, M.-J. M. (2019). Description and characterization of a hair coat disorder in schipperkes. Veterinary Dermatology, 30(1), 36-e10. https://doi.org/10.1111/vde.12711 |
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Grant Number: 02182-A Research Program Area: Dermatology and Allergic Disease |
Is Defective Secretion of Antimicrobial Peptides Associated with Reduced Microbicidal Effects in Atopic Keratinocytes? Santoro, D., Archer, L., & Kelley, K. (2019). A defective release of host defense peptides is present in canine atopic skin - ScienceDirect. Comparative Immunology, Microbiology and Infectious Diseases. https://doi.org/Comparative Immunology, Microbiology and Infectious Diseases |
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Grant Number: 02188-A Research Program Area: Reproductive Conditions |
Combined Anti-Mullerian Hormone and Progesterone Testing for the Diagnosis of Canine Ovarian Remnant Syndrome Place, N. J., Cheraskin, J.-L., & Hansen, B. S. (2019). Evaluation of combined assessments of serum anti-Müllerian hormone and progesterone concentrations for the diagnosis of ovarian remnant syndrome in dogs. Journal of the American Veterinary Medical Association, 254(9), 1067–1072. https://doi.org/10.2460/javma.254.9.1067 |
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Grant Number: 02228-MOU Research Program Area: General Canine Health |
Assessing the Genetic Diversity of North American Golden Retrievers Ontiveros, E. S., Hughes, S., Penedo, M. C. T., Grahn, R. A., & Stern, J. A. (2019). Genetic heterogeneity and diversity of North American golden retrievers using a low density STR marker panel. PLOS ONE, 14(2), e0212171. https://doi.org/10.1371/journal.pone.0212171 |
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Grant Number: 02424 Research Program Area: Cardiology |
Identification of Genetic Variants Associated with Pulmonary Valve Stenosis in Bulldogs through Whole-Genome Sequencing Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052 |
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Grant Number: 02233-A Research Program Area: Gastrointestinal Disease |
Evaluation of a Novel Technique for Gastric Decompression in Dogs with Gastric Dilatation and Volvulus Fox-Alvarez, W. A., Case, J. B., Lewis, D. D., Joyce, A. C., Cooke, K. L., & Toskich, B. (2019). Evaluation of a novel technique involving ultrasound-guided, temporary, percutaneous gastropexy and gastrostomy catheter placement for providing sustained gastric decompression in dogs with gastric dilatation-volvulus. Journal of the American Veterinary Medical Association, 255(9), 1027–1034. https://doi.org/10.2460/javma.255.9.1027
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Grant Number: 02343-A Research Program Area: Blood Disorders |
Recognizing and Removing Lipemic Interferences for Accurate Laboratory Testing Azevedo, C. N., Lidbury, J. A., & Jeffery, U. (2019). Effects of marked hypertriglyceridemia and lipid clearance techniques on canine biochemistry testing. Journal of Veterinary Diagnostic Investigation, 1040638719858690. https://doi.org/10.1177/1040638719858690 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
