1844: Treatment of Urinary Incontinence with Multipotent Muscle Cells: A Regenerative Medicine Approach to a Common Canine Health Problem

Grant Status: Open

Grant Amount: $116,184.24
Dr. Shelly Vaden, DVM PhD, North Carolina State University
January 1, 2013 - December 31, 2014
Sponsor(s): American Bouvier des Flandres Club - Bouvier Health Foundation, Boston Terrier Club of America
Breed(s): Giant Schnauzer, Rottweiler, English Springer Spaniel, Old English Sheepdog, Weimaraner, Doberman Pinscher, Golden Retriever, Irish Setter
Research Program Area: Renal Disease

Abstract

Urinary incontinence affects more than 20% of spayed female dogs, with medium and large breeds more commonly affected. In the majority of the cases urinary incontinence is caused by dysfunction of the muscles controlling the urethral sphincter. This results in uncontrolled loss of urine and can lead to serious bladder and kidney infections, in addition to irritation and/or ulceration of the skin in contact with the urine. Treatment can include hormone therapy, drugs designed to strengthen the muscle tone of the urethral sphincter, collagen injections, or surgery. Recently, Dr. Vaden's lab has reported that injection of muscle progenitor cells into damaged urethral sphincters can restore normal function in dogs. The purpose of this project is to extend those observations and examine the usefulness of cultured muscle cells for the restoration of function of the urethral sphincter in dogs with naturally occurring urinary incontinence. The effects of the procedure will be determined by owner reported continence scoring, as well as urodynamic testing that will provide an objective measurement for how well the bladder, sphincters, and urethra are storing and releasing urine.

Publication(s)

Manuscript in preparation.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Make an Investment Today:

  • $40
  • $60
  • $100
  • $250
  • Give Now
Connect With Us:
Get Canine Health News:
Please leave this field empty

© 2016 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software