Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 02458-A Research Program Area: Immunology and Infectious Disease |
A Laboratory Test for Detecting Drug Resistance in Canine Heartworm Disease Jesudoss Chelladurai, J. R. J., Martin, K. A., Chinchilla-Vargas, K., Jimenez Castro, P. D., Kaplan, R. M., & Brewer, M. T. (2020). Laboratory assays reveal diverse phenotypes among microfilariae of Dirofilaria immitis isolates with known macrocyclic lactone susceptibility status. PLOS ONE, 15(8), e0237150. https://doi.org/10.1371/journal.pone.0237150 |
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Grant Number: 2460 Research Program Area: Musculoskeletal Conditions and Disease |
Molecular Genetic Characterization of Mucopolysaccharidosis Type VI for the Development of a Carrier Test and Relationship to Legg-Calve-Perthes Disease Raj, K., Berman‐Booty, L., Foureman, P., & Giger, U. (2020). ARSB gene variants causing Mucopolysaccharidosis VI in Miniature Pinscher and Miniature Schnauzer dogs. Animal Genetics. https://doi.org/10.1111/age.13005 |
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Grant Number: 00754A Research Program Area: Oncology |
Mapping of the Gene for Transitional Cell Carcinoma in the Scottish Terrier & West Highland White Terrier Parker, H. G., Dhawan, D., Harris, A. C., Ramos-Vara, J. A., Davis, B. W., Knapp, D. W., & Ostrander, E. A. (2020). RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors BMC Cancer, 20(251). doi.org/10.1186/s12885-020-06737-0
Decker, B., Parker, H. G., Dhawan, D., Kwon, E. M., Karlins, E., Davis, B. W., … Ostrander, E. A. (2015). Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer--Evidence for a Relevant Model System and Urine-Based Diagnostic Test. Molecular Cancer Research, 13(6), 993–1002. https://doi.org/10.1158/1541-7786.MCR-14-0689
Dhawan, D., Ramos-Vara, J. A., Stewart, J. C., Zheng, R., & Knapp, D. W. (2009). Canine invasive transitional cell carcinoma cell lines: In vitro tools to complement a relevant animal model of invasive urinary bladder cancer. Urologic Oncology: Seminars and Original Investigations, 27(3), 284–292. https://doi.org/10.1016/j.urolonc.2008.02.015
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Grant Number: 01937-B Research Program Area: Gastrointestinal Disease |
Evaluating the Complex Genetic Basis of Bloat Piras, I. S., Perdigones, N., Zismann, V., Briones, N., Facista, S., Rivera, J. L., Rozanski, E., London, C. A., & Hendricks, W. P. D. (2020). Identification of Genetic Susceptibility Factors Associated with Canine Gastric Dilatation-Volvulus. Genes, 11(11), 1313. https://doi.org/10.3390/genes11111313 Bell, J. S. (2014). Inherited and Predisposing Factors in the Development of Gastric Dilatation Volvulus in Dogs. Topics in Companion Animal Medicine, 29(3), 60–63. https://doi.org/10.1053/j.tcam.2014.09.002 Sharp, C. R., & Rozanski, E. A. (2014). Cardiovascular and Systemic Effects of Gastric Dilatation and Volvulus in Dogs. Topics in Companion Animal Medicine, 29(3), 67–70. https://doi.org/10.1053/j.tcam.2014.09.007 Sharp, C. R., Rozanski, E. A., Finn, E., & Borrego, E. J. (2020). The pattern of mortality in dogs with gastric dilatation and volvulus. Journal of Veterinary Emergency and Critical Care. https://doi.org/10.1111/vec.12932 |
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Grant Number: 02249-A Research Program Area: Neurology, Epilepsy Initiative |
Studying the Role of the Gastrointestinal Tract in Canine Epilepsy Muñana, K. R., Jacob, M. E., & Callahan, B. J. (2020). Evaluation of fecal Lactobacillus populations in dogs with idiopathic epilepsy: A pilot study. Animal Microbiome, 2(1), 19. https://doi.org/10.1186/s42523-020-00036-6 |
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Grant Number: 02275 Research Program Area: Musculoskeletal Conditions and Disease |
Disease Risks Associated with Spay and Neuter: A Breed-Specific, Gender-Specific Perspective Hart, B. L., Hart, L. A., Thigpen, A. P., & Willits, N. H. (2020). Assisting Decision-Making on Age of Neutering for 35 Breeds of Dogs: Associated Joint Disorders, Cancers, and Urinary Incontinence. Frontiers in Veterinary Science, 7. https://doi.org/10.3389/fvets.2020.00388 |
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Grant Number: 02751-A Research Program Area: Oncology - Lymphoma |
Luteinizing Hormone Receptor Activation Induces Migration and Adhesion in Neoplastic Canine Lymphocytes Kutzler, M. A. (2020). Possible Relationship between Long-Term Adverse Health Effects of Gonad-Removing Surgical Sterilization and Luteinizing Hormone in Dogs. Animals: An Open Access Journal from MDPI, 10(4). https://doi.org/10.3390/ani10040599 |
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Grant Number: 02322 Research Program Area: General Canine Health |
Analysis of the Health, Behavioral, and Longevity Data Collected in the 9/11 Medical Surveillance Longitudinal Study Hare, E., Kelsey, K. M., Niedermeyer, G. M., & Otto, C. M. (2020). Long-Term Behavioral Resilience in Search-and-Rescue Dogs Responding to the September 11, 2001 Terrorist Attacks. Applied Animal Behaviour Science, 105173. https://doi.org/10.1016/j.applanim.2020.105173 Hare, E., Kelsey, K. M., Serpell, J. A., & Otto, C. M. (2018). Behavior Differences Between Search-and-Rescue and Pet Dogs. Frontiers in Veterinary Science, 5. https://doi.org/10.3389/fvets.2018.00118 Otto, C. M., Hare, E., Buchweitz, J. P., Kelsey, K. M., & Fitzgerald, S. D. (2020). Fifteen-year surveillance of pathological findings associated with death or euthanasia in search-and-rescue dogs deployed to the September 11, 2001, terrorist attack sites. Journal of the American Veterinary Medical Association, 257(7), 734–743. https://doi.org/10.2460/javma.257.7.734 Article: Surveillance of Search Dogs | Breeding Better Dogs. (2019). Retrieved November 4, 2019, from https://breedingbetterdogs.com/article/surveillance-search-dogs |
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Grant Number: 02340 Research Program Area: Ophthalmology |
Clinical and Genetic Background of Progressive Retinal Atrophy in Miniature Schnauzers Kaukonen, M., Quintero, I., Mukarram, A., Hytönen, M. K., Holopainen, S., Wickstrom, K., Kyostila, K., Arumilli, M., Jalomaki, S., Daub, C., Kere, J., Lohi, H., & The DoGA Consortium. (2020). A putative silencer variant in a spontaneous canine model of retinitis pigmentosa. PLOS Genetics, 16(3), e1008659. doi.org/10.1371/journal.pgen.1008659 |
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Grant Number: 2667 Research Program Area: Oncology |
Cellular Genomics - Molecular Cytogenetic Investigation of Canine Soft Tissue Sarcomas Hédan, B., Rault, M., Abadie, J., Ulvé, R., Botherel, N., Devauchelle, P., Copie‐Bergman, C., Cadieu, E., Parrens, M., Alten, J., Zalcman, E. L., Cario, G., Damaj, G., Mokhtari, K., Loarer, F. L., Coulomb‐Lhermine, A., Derrien, T., Hitte, C., Bachelot, L., … André, C. (2020). PTPN11 mutations in canine and human disseminated histiocytic sarcoma. International Journal of Cancer. https://doi.org/10.1002/ijc.32991
Breen, M. (2008). Canine cytogenetics - from band to basepair. Cytogenetic and Genome Research, 120(1–2), 50–60. https://doi.org/10.1159/000118740
Fosmire, S. P., Dickerson, E. B., Scott, A. M., Bianco, S. R., Pettengill, M. J., Meylemans, H., … Modiano, J. F. (2004). Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium. Laboratory Investigation, 84(5), 562–572. https://doi.org/10.1038/labinvest.3700080
Hedan, B., Thomas, R., Motsinger-Reif, A., Abadie, J., Andre, C., Cullen, J., & Breen, M. (2011). Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior. BMC Cancer, 11(1). https://doi.org/10.1186/1471-2407-11-201
Kennerly, E., Thomson, S., Olby, N., Breen, M., & Gibson, G. (2004). Comparison of regional gene expression differences in the brains of the domestic dog and human. Human Genomics, 1(6), 435. https://doi.org/10.1186/1479-7364-1-6-435
Modiano, J F, Breen, M., Valli, V. E. O., Wojcieszyn, J. W., & Cutter, G. R. (2007). Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin’s lymphoma. Leukemia, 21(1), 184–187. https://doi.org/10.1038/sj.leu.2404392
Modiano, Jaime F, Breen, M., Lana, S. E., Ehrhart, N., Fosmire, S. P., Thomas, R., … Bellgrau, D. (2006). Naturally occurring translational models for development of cancer gene therapy. Gene Therapy and Molecular Biology, 10, 31–40.
Philipp, U., Quignon, P., Scott, A., Rak, S., André, C., Breen, M., & Leeb, T. (2003). Assignment of the canine myosin Va gene (MYO5A) to chromosome 30q14 by fluorescence in situ hybridization and radiation hybrid mapping. Cytogenetic and Genome Research, 101(1), 92C-92C. https://doi.org/10.1159/000073681
Philipp, U., Scott, A., Quignon, P., André, C., Breen, M., & Leeb, T. (2003). Assignment of the RAB27A gene to canine chromosome 30q15.1 by fluorescence in situ hybridization and radiation hybrid mapping. Cytogenetic and Genome Research, 101(1), 92E. https://doi.org/10.1159/000073683
Rak, S. G., Drogemuller, C., Leeb, T., Quignon, P., Andre, C., & Scott, A. (2003). Chromosomal assignment of 20 candidate genes for canine congenital sensorineural deafness by FISH and RH mapping. Cytogenetic and Genome Research, 101(2), 130–135.
Tiret, L., Blot, S., Kessler, J.-L., Gaillot, H., Breen, M., & Panthier, J.-J. (2003). The cnm locus, a canine homologue of human autosomal forms of centronuclear myopathy, maps to chromosome2. Human Genetics, 113(4), 297–306. https://doi.org/10.1007/s00439-003-0984-7
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Grant Number: 01557 Research Program Area: Oncology |
Narrowing the Search for the Genetic Basis of Histiocytic Malignancies Hédan, B., Rault, M., Abadie, J., Ulvé, R., Botherel, N., Devauchelle, P., Copie‐Bergman, C., Cadieu, E., Parrens, M., Alten, J., Zalcman, E. L., Cario, G., Damaj, G., Mokhtari, K., Loarer, F. L., Coulomb‐Lhermine, A., Derrien, T., Hitte, C., Bachelot, L., … André, C. (2020). PTPN11 mutations in canine and human disseminated histiocytic sarcoma. International Journal of Cancer. https://doi.org/10.1002/ijc.32991 Kennedy, K., Thomas, R., Durrant, J., Jiang, T., Motsinger-Reif, A., & Breen, M. (2019). Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex. Chromosome Research. https://doi.org/10.1007/s10577-019-09606-0 Kennedy, K., Thomas, R., & Breen, M. (2016). Canine Histiocytic Malignancies—Challenges and Opportunities. Veterinary Sciences, 3(1), 2. https://doi.org/10.3390/vetsci3010002 |
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Grant Number: 01577 Research Program Area: Oncology |
Identifying the Genes Conferring Risk for Transitional Cell Carcinoma Parker, H. G., Dhawan, D., Harris, A. C., Ramos-Vara, J. A., Davis, B. W., Knapp, D. W., & Ostrander, E. A. (2020). RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors. BMC Cancer, 20(251). https://doi.org/10.1186/s12885-020-06737-0 Decker, B., Parker, H. G., Dhawan, D., Kwon, E. M., Karlins, E., Davis, B. W., … Ostrander, E. A. (2015). Homologous Mutation to Human BRAF V600E Is Common in Naturally Occurring Canine Bladder Cancer--Evidence for a Relevant Model System and Urine-Based Diagnostic Test. Molecular Cancer Research, 13(6), 993–1002. https://doi.org/10.1158/1541-7786.MCR-14-0689
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Grant Number: 02633 Research Program Area: Immunology and Infectious Disease |
Validation and Diagnostic Performance of a Novel Monoclonal Antibody based Histoplasma Urine Immunoassay in Dogs with Histoplasmosis Clark, K., & Hanzlicek, A. S. (2020). Evaluation of a novel monoclonal antibody-based enzyme immunoassay for detection of Histoplasma antigen in urine of dogs. Journal of Veterinary Internal Medicine, 1–20. https://doi.org/10.1111/jvim.16006 |
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Grant Number: 02264-A Research Program Area: Reproductive Conditions |
Role of E. Coli Biofilm in Canine Pyometra Fiamengo, T. E., Runcan, E. E., Premanandan, C., Blawut, B., & Coutinho da Silva, M. A. (2020). Evaluation of biofilm production by Escherichia coli isolated from clinical cases of canine pyometra. Topics in Companion Animal Medicine, 100429. https://doi.org/10.1016/j.tcam.2020.100429 |
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Grant Number: 02643-A Research Program Area: Oncology |
Examination of the Effects of Cannabidiol on Canine Neoplastic Cell Apoptosis/Autophagy and Potential for Chemotherapy Resistance or Sensitivity Henry, J. G., Shoemaker, G., Prieto, J. M., Hannon, M. B., & Wakshlag, J. J. (2020). The effect of cannabidiol on canine neoplastic cell proliferation and mitogen-activated protein kinase activation during autophagy and apoptosis. Veterinary and Comparative Oncology, e12669, e12669. https://doi.org/10.1111/vco.12669 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
