Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 02782 Research Program Area: Oncology - Osteosarcoma |
Genetic Contribution to Early-onset Osteosarcoma Momen, M., Kohler, N. L., Binversie, E. E., Dentino, M., & Sample, S. J. (2021). Heritability and genetic variance estimation of Osteosarcoma (OSA) in Irish Wolfhound, using deep pedigree information. Canine Medicine and Genetics, 8(1), 9. https://doi.org/10.1186/s40575-021-00109-y |
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Grant Number: 02388-MOU Research Program Area: Cardiology |
Genetic Markers for Familial Subvalvular Aortic Stenosis in Newfoundlands Ontiveros, E. S., & Stern, J. A. (2021). Genetics of canine subvalvular aortic stenosis (SAS). Canine Medicine and Genetics, 8(1), 4. https://doi.org/10.1186/s40575-021-00103-4 Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052 |
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Grant Number: 02575-MOU Research Program Area: Neurology |
Genetic Basis of Exercise-Induced Collapse in Border Collie Related Breeds Norton, E. M., Minor, K. M., Taylor, S. M., McCue, M. E., & Mickelson, J. R. (2021). Heritability and Genomic Architecture of Episodic Exercise-Induced Collapse in Border Collies. Genes, 12(12), 1927. https://doi.org/10.3390/genes12121927 |
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Grant Number: 02797 Research Program Area: General Canine Health |
Do Dog Breeds Differ in Pain Sensitivity? Cunningham, R. M., Park, R. M., Knazovicky, D., Lascelles, B. D. X., & Gruen, M. E. (2021). Assessment of Sensory Thresholds in Dogs using Mechanical and Hot Thermal Quantitative Sensory Testing. JoVE (Journal of Visualized Experiments), 176, e62841. https://doi.org/10.3791/62841 |
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Grant Number: 01236-A Research Program Area: Endocrinology |
Hypothyroidism and Autoimmune Susceptibility Genes in the Bearded Collie Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2021). Whole Genome Sequencing Reveals Multiple Linked Genetic Variants on Canine Chromosome 12 Associated with Risk for Symmetrical Lupoid Onychodystrophy (SLO) in the Bearded Collie. Genes, 12(8), 1265. https://doi.org/10.3390/genes12081265 Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., Famula, T. R., & Oberbauer, A. M. (2020). Genetic characterization of Addison’s disease in Bearded Collies. BMC Genomics, 21(1), 833. https://doi.org/10.1186/s12864-020-07243-0 Gershony, L. C., Belanger, J. M., Short, A. D., Le, M., Hytönen, M. K., Lohi, H., … Oberbauer, A. M. (2019). DLA class II risk haplotypes for autoimmune diseases in the Bearded Collie offer insight to autoimmunity signatures across dog breeds. Canine Genetics and Epidemiology, 6(1), 2. https://doi.org/10.1186/s40575-019-0070-7 Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2019). Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie. Genes, 10(9), 635. doi.org/10.3390/genes10090635 Rincon, G., Tengvall, K., Belanger, J. M., Lagoutte,L., Medrano, J. F., André, C., … Oberbauer, A. M. (2011). Comparison of buccaland blood-derived canine DNA, either native or whole genome amplified, forarray-based genome-wide association studies. BMC Research Notes, 4(1),226. https://doi.org/10.1186/1756-0500-4-226 |
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Grant Number: 01609 Research Program Area: Gastrointestinal Disease |
Use of Probiotic to Reduce the Symptoms of Inflammatory Bowel Disease White, R., Atherly, T., Guard, B., Rossi, G., Wang, C., Mosher, C., Webb, C., Hill, S., Ackermann, M., Sciabarra, P., Allenspach, K., Suchodolski, J., & Jergens, A. E. (2017). Randomized, controlled trial evaluating the effect of multi-strain probiotic on the mucosal microbiota in canine idiopathic inflammatory bowel disease. Gut Microbes, 8(5), 451–466. https://doi.org/10.1080/19490976.2017.1334754 Pilla, R., Guard, B.C., Blake, A.B., Ackermann, M., Webb, C.; Hill, S., Lidbury, J.A., Steiner, J.M., Jergens, A.E., Suchodolski, J.S. (2021). Long-Term Recovery of the Fecal Microbiome and Metabolome of Dogs with Steroid-Responsive Enteropathy. Animals. 11 (6), 2498. https://doi.org/10.3390/ani11092498 Minamoto, Y., Otoni, C. C., Steelman, S. M., Büyükleblebici, O., Steiner, J. M., Jergens, A. E., & Suchodolski, J. S. (2015). Alteration of the fecal microbiota and serum metabolite profiles in dogs with idiopathic inflammatory bowel disease. Gut Microbes, 6(1), 33–47. https://doi.org/10.1080/19490976.2014.997612 Otoni, C. C., Heilmann, R. M., García‐Sancho, M., Sainz, A., Ackermann, M. R., Suchodolski, J. S., … Jergens, A. E. (2018). Serologic and fecal markers to predict response to induction therapy in dogs with idiopathic inflammatory bowel disease. Journal of Veterinary Internal Medicine, 32(3), 999–1008. https://doi.org/10.1111/jvim.15123 Rossi, G., Pengo, G., Caldin, M., Palumbo Piccionello, A., Steiner, J. M., Cohen, N. D., … Suchodolski, J. S. (2014). Comparison of Microbiological, Histological, and Immunomodulatory Parameters in Response to Treatment with Either Combination Therapy with Prednisone and Metronidazole or Probiotic VSL#3 Strains in Dogs with Idiopathic Inflammatory Bowel Disease. PLoS ONE, 9(4), e94699. https://doi.org/10.1371/journal.pone.0094699 |
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Grant Number: 02520-MOU Research Program Area: Cardiology |
Identification of Genetic Markers for Familial Subvalvular Aortic Stenosis in Rottweilers Ontiveros, E. S., & Stern, J. A. (2021). Genetics of canine subvalvular aortic stenosis (SAS). Canine Medicine and Genetics, 8(1), 4. https://doi.org/10.1186/s40575-021-00103-4 Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052 |
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Grant Number: 02417-A Research Program Area: Endocrinology |
Serum total histones in dogs with acute pancreatitis, their association with laboratory findings, markers of inflammation and outcome: a prospective longitudinal study Nivy, R., Kuzi, S., Yochai, A., Aroch, I., & Bruchim, Y. (2021). Evaluation of serum histone concentrations and their associations with hemostasis, markers of inflammation, and outcome in dogs with naturally occurring acute pancreatitis. American Journal of Veterinary Research, 82(9), 701–711. https://doi.org/10.2460/ajvr.82.9.701 |
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Grant Number: 02488 Research Program Area: Endocrinology |
Addison's Disease and Symmetrical Lupoid Onychodystrophy in Bearded Collies Provide Common Ground for Identifying Susceptibility Loci Underlying Canine Autoimmune Disorders Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2021). Whole Genome Sequencing Reveals Multiple Linked Genetic Variants on Canine Chromosome 12 Associated with Risk for Symmetrical Lupoid Onychodystrophy (SLO) in the Bearded Collie. Genes, 12(8), 1265. https://doi.org/10.3390/genes12081265 Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., Famula, T. R., & Oberbauer, A. M. (2020). Genetic characterization of Addison’s disease in Bearded Collies. BMC Genomics, 21(1), 833. https://doi.org/10.1186/s12864-020-07243-0 Gershony, L. C., Belanger, J. M., Short, A. D., Le, M., Hytönen, M. K., Lohi, H., … Oberbauer, A. M. (2019). DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds. Canine Genetics and Epidemiology, 6(1), 2. https://doi.org/10.1186/s40575-019-0070-7 Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2019). Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie. Genes, 10(9), 635. doi.org/10.3390/genes10090635 |
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Grant Number: 02521-MOU Research Program Area: Cardiology |
Identification of Genetic Markers for Familial Subvalvular Aortic Stenosis in Golden Retrievers Ontiveros, E. S., & Stern, J. A. (2021). Genetics of canine subvalvular aortic stenosis (SAS). Canine Medicine and Genetics, 8(1), 4. https://doi.org/10.1186/s40575-021-00103-4 Ontiveros, E. S., Fousse, S. L., Crofton, A. E., Hodge, T. E., Gunther-Harrington, C. T., Visser, L. C., & Stern, J. A. (2019). Congenital Cardiac Outflow Tract Abnormalities in Dogs: Prevalence and Pattern of Inheritance From 2008 to 2017. Frontiers in Veterinary Science, 6. https://doi.org/10.3389/fvets.2019.00052 |
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Grant Number: 02172-MOU Research Program Area: Neurology |
Understanding Hereditary Deafness in Dogs Seddon, J. M., Fortes, M., Kelly-Smith, M., Sommerlad, S. F., Hayward, J. J., Burmeister, L., Risio, L. D., Mellersh, C., Freeman, J., & Strain, G. M. (2021). Deafness in Australian Cattle Dogs associated to QTL on chromosome 20 in genome-wide association study analyses. Animal Genetics. https://doi.org/10.1111/age.13115 Kelly-Smith, M., & Strain, G. M. (2020). STRING Data Mining of GWAS Data in Canine Hereditary Pigment-Associated Deafness. Veterinary and Animal Science, 100118. https://doi.org/10.1016/j.vas.2020.100118 Hayward, J. J., Kelly-Smith, M., Boyko, A. R., Burmeister, L., De Risio, L., Mellersh, C., Freeman, J., & Strain, G. M. (2020). A genome-wide association study of deafness in three canine breeds. PLOS ONE, 15(5), e0232900. https://doi.org/10.1371/journal.pone.0232900 |
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Grant Number: 02700 Research Program Area: Behavior |
Longitudinal Comparison of Cognitive and Emotional Development in Assistance Dog Puppies
Bray EE, Gruen ME, Gnanadesikan GE, et al. Dog cognitive development: a longitudinal study across the first 2 years of life. Anim Cogn. 2021;24(2):311-328. doi:10.1007/s10071-020-01443-7 Piotti P, Albertini M, Trabucco LP, Ripari L, Karagiannis C, Bandi C, Pirrone F. Personality and Cognitive Profiles of Animal-Assisted Intervention Dogs and Pet Dogs in an Unsolvable Task. Animals. 2021; 11(7):2144. https://doi.org/10.3390/ani11072144 Salomons, H., Smith, K. C. M., Callahan-Beckel, M., Callahan, M., Levy, K., Kennedy, B. S., Bray, E. E., Gnanadesikan, G. E., Horschler, D. J., Gruen, M., Tan, J., White, P., vonHoldt, B. M., MacLean, E. L., & Hare, B. (2021). Cooperative Communication with Humans Evolved to Emerge Early in Domestic Dogs. Current Biology. https://doi.org/10.1016/j.cub.2021.06.051 Bray, E. E., Gruen, M. E., Gnanadesikan, G. E., Horschler, D. J., Levy, K. M., Kennedy, B. S., Hare, B. A., & MacLean, E. L. (2020). Dog cognitive development: A longitudinal study across the first 2 years of life. Animal Cognition. https://doi.org/10.1007/s10071-020-01443-7 Hare, B., & Ferrans, M. (2021). Is cognition the secret to working dog success? Animal Cognition, 24(2), 231–237. https://doi.org/10.1007/s10071-021-01491-7 |
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Grant Number: 02387-MOU Research Program Area: Neurology |
Hereditary Deafness in Dogs – Genomic Studies in English Setters Using Full Sibling Pairs Seddon, J. M., Fortes, M., Kelly-Smith, M., Sommerlad, S. F., Hayward, J. J., Burmeister, L., Risio, L. D., Mellersh, C., Freeman, J., & Strain, G. M. (2021). Deafness in Australian Cattle Dogs associated to QTL on chromosome 20 in genome-wide association study analyses. Animal Genetics. https://doi.org/10.1111/age.13115 Kelly-Smith, M., & Strain, G. M. (2020). STRING Data Mining of GWAS Data in Canine Hereditary Pigment-Associated Deafness. Veterinary and Animal Science, 100118. https://doi.org/10.1016/j.vas.2020.100118 Hayward, J. J., Kelly-Smith, M., Boyko, A. R., Burmeister, L., De Risio, L., Mellersh, C., Freeman, J., & Strain, G. M. (2020). A genome-wide association study of deafness in three canine breeds. PLOS ONE, 15(5), e0232900. https://doi.org/10.1371/journal.pone.0232900 |
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Grant Number: 2646 Research Program Area: Musculoskeletal Conditions and Disease |
Effect of Hyperthermia on Skeletal Muscle Energy Efficiency Davis, M. S., & Barrett, M. R. (2021). Effect of conditioning and physiology hyperthermia on canine skeletal muscle mitochondrial oxygen consumption. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00969.2020 |
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Grant Number: 01889-G Research Program Area: Oncology |
Innovations in Prevention, Diagnosis, and Treatment of Cancer - Goldens Lead the Way Kim, J. H., Megquier, K., Thomas, R., Sarver, A. L., Song, J. M., Kim, Y. T., Cheng, N., Schulte, A. J., Linden, M. A., Murugan, P., Oseth, L., Forster, C. L., Elvers, I., Swofford, R., Turner-Maier, J., Karlsson, E. K., Breen, M., Lindblad-Toh, K., & Modiano, J. F. (2021). Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0937 Borgatti, A., Fieberg, A., Winter, A. L., Stuebner, K., Taras, E., Todhunter, D., Masyr, A., Rendhal, A., Vallera, D. A., Koopmeiners, J. S., & Modiano, J. F. (2020). Impact of Repeated Cycles of EGF Bispecific Angiotoxin (eBAT) Administered at a Reduced Interval from Doxorubicin Chemotherapy in Dogs with Splenic Hemangiosarcoma. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12590
Borgatti, A., Koopmeiners, J. S., Sarver, A. L., Winter, A. L., Stuebner, K., Todhunter, D., … Vallera, D. A. (2017). Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR. Molecular Cancer Therapeutics, 16(5), 956–965. https://doi.org/10.1158/1535-7163.MCT-16-0637
Elvers, I., Turner-Maier, J., Swofford, R., Koltookian, M., Johnson, J., Stewart, C., … Alföldi, J. (2015). Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background. Genome Research, 25(11), 1634–1645. https://doi.org/10.1101/gr.194449.115
Gorden, B. H., Kim, J.-H., Sarver, A. L., Frantz, A. M., Breen, M., Lindblad-Toh, K., … Dickerson, E. B. (2014). Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization. The American Journal of Pathology, 184(4), 985–995. https://doi.org/10.1016/j.ajpath.2013.12.025
Im, K. S., Graef, A. J., Breen, M., Lindblad-Toh, K., Modiano, J. F., & Kim, J.-H. (2015). Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma: CXCR4/CXCL12 in HSA migration and invasion. Veterinary and Comparative Oncology, 15(2), 315–327. https://doi.org/10.1111/vco.12165
Seelig, D. M., Ito, D., Forster, C. L., Yoon, U. A., Breen, M., Burns, L. J., … Linden, M. A. (2017). Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies. Leukemia & Lymphoma, 58(7), 1702–1710. https://doi.org/10.1080/10428194.2016.1260122
Thomas, R., Borst, L., Rotroff, D., Motsinger-Reif, A., Lindblad-Toh, K., Modiano, J. F., & Breen, M. (2014). Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma. Chromosome Research, 22(3), 305–319. https://doi.org/10.1007/s10577-014-9406-z
Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922
Megquier, K., Turner-Maier, J., Swofford, R., Kim, J.-H., Sarver, A. L., Wang, C., … Lindblad-Toh, K. (2019). Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma. Molecular Cancer Research, 17(12), 2410–2421 https://doi.org/10.1158/1541-7786.MCR-19-0221 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
