Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 02164-MOU Research Program Area: Ophthalmology |
Determining the Genetic Contribution to Boxer Corneal Ulcers Meurs, K. M., Montgomery, K., Friedenberg, S. G., Williams, B., & Gilger, B. C. (2021). A defect in the NOG gene increases susceptibility to spontaneous superficial chronic corneal epithelial defects (SCCED) in boxer dogs. BMC Veterinary Research, 17(1), 254. https://doi.org/10.1186/s12917-021-02955-1 |
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Grant Number: 02321 Research Program Area: Oncology |
Clinical Trial of Procaspase-3 Activator (PAC-1) in Combination with Hydroxyurea for Treatment of Canine Meningioma Tonogai, E. J., Huang, S., Botham, R. C., Berry, M. R., Joslyn, S. K., Daniel, G. B., Chen, Z., Rao, J., Zhang, X., Basuli, F., Rossmeisl, J. H., Riggins, G. J., LeBlanc, A. K., Fan, T. M., & Hergenrother, P. J. (2021). Evaluation of a procaspase-3 activator with hydroxyurea or temozolomide against high-grade meningioma in cell culture and canine cancer patients. Neuro-Oncology, noab161. https://doi.org/10.1093/neuonc/noab161 Schlein, L. J., Fadl-Alla, B., Pondenis, H. C., Lezmi, S., Eberhart, C. G., LeBlanc, A. K., … Fan, T. M. (2019). Immunohistochemical Characterization of Procaspase-3 Overexpression as a Druggable Target With PAC-1, a Procaspase-3 Activator, in Canine and Human Brain Cancers. Frontiers in Oncology, 9 (96). https://doi.org/10.3389/fonc.2019.00096 |
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Grant Number: 02489 Research Program Area: Oncology |
Tumor-permissive Collagen Signatures in Canine Mammary Gland Tumors: Development of Prognostic Markers and Targeted Therapies for Improved Outcomes Terajima, M., Taga, Y., Brisson, B. K., Durham, A. C., Sato, K., Uzawa, K., Saito, T., Hattori, S., Sørenmo, K. U., Yamauchi, M., & Volk, S. W. (2021). Collagen molecular phenotypic switch between non-neoplastic and neoplastic canine mammary tissues. Scientific Reports, 11(1), 8659. https://doi.org/10.1038/s41598-021-87380-y |
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Grant Number: 02519 Research Program Area: Tick-Borne Disease Initiative , Oncology - Hemangiosarcoma |
Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangiosarcomas within and between Geographic Locations Lashnits, E., Neupane, P., Bradley, J. M., Richardson, T., Maggi, R. G., & Breitschwerdt, E. B. (2021). Comparison of Serological and Molecular Assays for Bartonella Species in Dogs with Hemangiosarcoma. Pathogens, 10(7), 794. https://doi.org/10.3390/pathogens10070794 Lashnits, E., Neupane, P., Bradley, J. M., Richardson, T., Thomas, R., Linder, K. E., Breen, M., Maggi, R. G., & Breitschwerdt, E. B. (2020). Molecular prevalence of Bartonella, Babesia, and hemotropic Mycoplasma species in dogs with hemangiosarcoma from across the United States. PLOS ONE, 15(1), e0227234. https://doi.org/10.1371/journal.pone.0227234 Maggi, R. G., Richardson, T., Breitschwerdt, E. B., & Miller, J. C. (2020). Development and validation of a droplet digital PCR assay for the detection and quantification of Bartonella species within human clinical samples. Journal of Microbiological Methods, 176, 106022. https://doi.org/10.1016/j.mimet.2020.106022 Neupane, P., Sevala, S., Balakrishnan, N., Marr, H., Wilson, J., Maggi, R., Birkenheuer, A., Lappin, M., Chomel, B., & Breitschwerdt, E. B. (2020). Validation of Bartonella henselae Western Immunoblotting for Serodiagnosis of Bartonelloses in Dogs. Journal of Clinical Microbiology. https://doi.org/10.1128/JCM.01335-19 |
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Grant Number: 2646 Research Program Area: Musculoskeletal Conditions and Disease |
Effect of Hyperthermia on Skeletal Muscle Energy Efficiency Davis, M. S., & Barrett, M. R. (2021). Effect of conditioning and physiology hyperthermia on canine skeletal muscle mitochondrial oxygen consumption. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.00969.2020 |
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Grant Number: 01889-G Research Program Area: Oncology |
Innovations in Prevention, Diagnosis, and Treatment of Cancer - Goldens Lead the Way Kim, J. H., Megquier, K., Thomas, R., Sarver, A. L., Song, J. M., Kim, Y. T., Cheng, N., Schulte, A. J., Linden, M. A., Murugan, P., Oseth, L., Forster, C. L., Elvers, I., Swofford, R., Turner-Maier, J., Karlsson, E. K., Breen, M., Lindblad-Toh, K., & Modiano, J. F. (2021). Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0937 Borgatti, A., Fieberg, A., Winter, A. L., Stuebner, K., Taras, E., Todhunter, D., Masyr, A., Rendhal, A., Vallera, D. A., Koopmeiners, J. S., & Modiano, J. F. (2020). Impact of Repeated Cycles of EGF Bispecific Angiotoxin (eBAT) Administered at a Reduced Interval from Doxorubicin Chemotherapy in Dogs with Splenic Hemangiosarcoma. Veterinary and Comparative Oncology. https://doi.org/10.1111/vco.12590
Borgatti, A., Koopmeiners, J. S., Sarver, A. L., Winter, A. L., Stuebner, K., Todhunter, D., … Vallera, D. A. (2017). Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR. Molecular Cancer Therapeutics, 16(5), 956–965. https://doi.org/10.1158/1535-7163.MCT-16-0637
Elvers, I., Turner-Maier, J., Swofford, R., Koltookian, M., Johnson, J., Stewart, C., … Alföldi, J. (2015). Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background. Genome Research, 25(11), 1634–1645. https://doi.org/10.1101/gr.194449.115
Gorden, B. H., Kim, J.-H., Sarver, A. L., Frantz, A. M., Breen, M., Lindblad-Toh, K., … Dickerson, E. B. (2014). Identification of Three Molecular and Functional Subtypes in Canine Hemangiosarcoma through Gene Expression Profiling and Progenitor Cell Characterization. The American Journal of Pathology, 184(4), 985–995. https://doi.org/10.1016/j.ajpath.2013.12.025
Im, K. S., Graef, A. J., Breen, M., Lindblad-Toh, K., Modiano, J. F., & Kim, J.-H. (2015). Interactions between CXCR4 and CXCL12 promote cell migration and invasion of canine hemangiosarcoma: CXCR4/CXCL12 in HSA migration and invasion. Veterinary and Comparative Oncology, 15(2), 315–327. https://doi.org/10.1111/vco.12165
Seelig, D. M., Ito, D., Forster, C. L., Yoon, U. A., Breen, M., Burns, L. J., … Linden, M. A. (2017). Constitutive activation of alternative nuclear factor kappa B pathway in canine diffuse large B-cell lymphoma contributes to tumor cell survival and is a target of new adjuvant therapies. Leukemia & Lymphoma, 58(7), 1702–1710. https://doi.org/10.1080/10428194.2016.1260122
Thomas, R., Borst, L., Rotroff, D., Motsinger-Reif, A., Lindblad-Toh, K., Modiano, J. F., & Breen, M. (2014). Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma. Chromosome Research, 22(3), 305–319. https://doi.org/10.1007/s10577-014-9406-z
Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Lindblad-Toh, K. (2015). Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers. PLOS Genetics, 11(2), e1004922. https://doi.org/10.1371/journal.pgen.1004922
Megquier, K., Turner-Maier, J., Swofford, R., Kim, J.-H., Sarver, A. L., Wang, C., … Lindblad-Toh, K. (2019). Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma. Molecular Cancer Research, 17(12), 2410–2421 https://doi.org/10.1158/1541-7786.MCR-19-0221 |
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Grant Number: 1988 Research Program Area: Immunology and Infectious Disease |
Identification of a Safe Storage Time for Canine Blood Used In the Treatment of AnemiaCallan, M. B., Thawley, V. J., Marryott, K. A., Shabro, A., Fernando, S., Kahn, S., Hudson, K. E., & Hod, E. A. (2021). Hemolytic anemia blunts the cytokine response to transfusion of older red blood cells in mice and dogs. Transfusion. https://doi.org/10.1111/trf.16690 |
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Grant Number: 02162-MOU Research Program Area: Neurology |
Defining The Genetic Foundations of Chiari-Like Malformation and Syringomyelia as a Tool to Better Treat Neuropathic Pain in the Dog Sparks, C. R., Woelfel, C., Robertson, I., & Olby, N. J. (2021). Association between filum terminale internum length and pain in Cavalier King Charles spaniels with and without syringomyelia. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16023 Sparks, C. R., Cerda‐Gonzalez, S., Griffith, E. H., Lascelles, B. D. X., & Olby, N. J. (2018). Questionnaire-based Analysis of Owner-reported Scratching and Pain Signs in Cavalier King Charles Spaniels Screened for Chiari-like Malformation and Syringomyelia. Journal of Veterinary Internal Medicine, 32(1), 331–339. https://doi.org/10.1111/jvim.14856 Sparks, C. R., Robertson, I., & Olby, N. J. (2019). Morphometric analysis of spinal cord termination in Cavalier King Charles Spaniels. Journal of Veterinary Internal Medicine, 1–9. https://doi.org/10.1111/jvim.15437 Sparks, Courtney R., Gorney, A., Williams, K., Griffith, E. H., Cerda‐Gonzalez, S., Lascelles, B. D. X., & Olby, N. J. (2018). Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari-like malformations and syringomyelia. Journal of Veterinary Internal Medicine, 32(6), 2021–2028. https://doi.org/10.1111/jvim.15297 |
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Grant Number: 02368 Research Program Area: Cardiology |
Identification of Mitral Valve Disease DNA variants in Miniature Schnauzers Williams, B., Friedenberg, S. G., Keene, B. W., Tou, S. P., DeFrancesco, T. C., & Meurs, K. M. (2021). Use of whole genome analysis to identify shared genomic variants across breeds in canine mitral valve disease. Human Genetics. https://doi.org/10.1007/s00439-021-02297-w |
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Grant Number: 02232-MOU Research Program Area: Lung and Respiratory Disease |
Characterization of Upper Airway Syndrome in Norwich Terriers Johnson, L. R., Mayhew, P. D., Culp, W. T. N., & Stanley, B. J. (2021). Results of owner questionnaires describing long-term outcome in Norwich terriers with upper airway syndrome: 2011-2018. Journal of Veterinary Internal Medicine, (1-7). https://doi.org/10.1111/jvim.16180 |
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Grant Number: 02066 Research Program Area: Kidney & Urological Disease |
Identification of Novel Biomarkers and Therapeutic Targets for Chronic Kidney Disease in Dogs Chu, C. P., Liu, S., Song, W., Xu, E. Y., & Nabity, M. B. (2021). Small RNA sequencing evaluation of renal microRNA biomarkers in dogs with X-linked hereditary nephropathy. Scientific Reports, 11(1), 17437. https://doi.org/10.1038/s41598-021-96870-y Hokamp, J. A., Cianciolo, R. E., Boggess, M., Lees, G. E., Benali, S. L., Kovarsky, M., & Nabity, M. B. (2016). Correlation of Urine and Serum Biomarkers with Renal Damage and Survival in Dogs with Naturally Occurring Proteinuric Chronic Kidney Disease. J Vet Intern Med, 30(2), 591-601. doi:10.1111/jvim.13832 Chu, C. P., & Nabity, M. B. (2019). Comparison of RNA isolation and library preparation methods for small RNA sequencing of canine biofluids. Veterinary Clinical Pathology, 0(0). https://doi.org/10.1111/vcp.12743 |
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Grant Number: 02187-MOU Research Program Area: Immunology and Infectious Disease |
Investigating Symmetrical Lupoid Onychodystrophy in Bearded Collies Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2021). Whole Genome Sequencing Reveals Multiple Linked Genetic Variants on Canine Chromosome 12 Associated with Risk for Symmetrical Lupoid Onychodystrophy (SLO) in the Bearded Collie. Genes, 12(8), 1265. https://doi.org/10.3390/genes12081265 Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., Famula, T. R., & Oberbauer, A. M. (2020). Genetic characterization of Addison’s disease in Bearded Collies. BMC Genomics, 21(1), 833. https://doi.org/10.1186/s12864-020-07243-0 Gershony, L. C., Belanger, J. M., Short, A. D., Le, M., Hytönen, M. K., Lohi, H., … Oberbauer, A. M. (2019). DLA class II risk haplotypes for autoimmune diseases in the bearded collie offer insight to autoimmunity signatures across dog breeds. Canine Genetics and Epidemiology, 6(1), 2. https://doi.org/10.1186/s40575-019-0070-7 Gershony, L. C., Belanger, J. M., Hytönen, M. K., Lohi, H., & Oberbauer, A. M. (2019). Novel Locus Associated with Symmetrical Lupoid Onychodystrophy in the Bearded Collie. Genes, 10(9), 635. doi.org/10.3390/genes10090635 |
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Grant Number: 02380-A Research Program Area: Immunology and Infectious Disease |
Estimating Prevalence and Identifying Risk Factors for Canine Leptospirosis in North America Smith, A. M., Stull, J. W., Evason, M. D., Weese, J. S., Wittum, T. E., Szlosek, D., & Arruda, A. G. (2021). Investigation of spatio-temporal clusters of positive leptospirosis polymerase chain reaction test results in dogs in the United States, 2009 to 2016. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.16060 -Leptospirosis Information for Dog Owners Smith, A. M., Arruda, A. G., Evason, M. D., Weese, J. S., Wittum, T. E., Szlosek, D., & Stull, J. W. (2019). A cross-sectional study of environmental, dog, and human-related risk factors for positive canine leptospirosis PCR test results in the United States, 2009 to 2016. BMC Veterinary Research, 15(1), 412. doi.org/10.1186/s12917-019-2148-6 |
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Grant Number: 02456-A Research Program Area: Oncology |
The Impact of Intravenous Anesthetic Agents on Canine Natural Killer Cell Barr, C. A., Alvarado, F., Chang, Y.-M., Luo, J., & Garden, O. A. (2021). The impact of alfaxalone, propofol and ketamine on canine peripheral blood lymphocyte cytotoxicity in vitro. Research in Veterinary Science, 136, 182–184. https://doi.org/10.1016/j.rvsc.2021.02.019 |
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Grant Number: 02528 Research Program Area: Tick-Borne Disease Initiative |
Developing a Next Generation Sequencing Diagnostic Platform for Tickborne Diseases Oney, K., Koo, M., Roy, C., Ren, S., Qurollo, B., Juhasz, N. B., Vasconcelos, E. J. R., Oakley, B., & Diniz, P. P. V. P. (2021). Evaluation of a commercial microbial enrichment kit used prior DNA extraction to improve the molecular detection of vector-borne pathogens from naturally infected dogs. Journal of Microbiological Methods, 106163. https://doi.org/10.1016/j.mimet.2021.106163 Vasconcelos, E. J. R., Roy, C., Geiger, J. A., Oney, K. M., Koo, M., Ren, S., Oakley, B. B., & Diniz, P. P. V. P. (2021). Data analysis workflow for the detection of canine vector-borne pathogens using 16 S rRNA Next-Generation Sequencing. BMC Veterinary Research, 17(1), 262. https://doi.org/10.1186/s12917-021-02969-9 |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
