Immunology and Infectious Disease Grants
The Immunology Research Program Area is combined with the Infectious Disease Research Program Area because there is substantial overlap in protection against and resolution of pathogenic infection and immunity against pathogens. This research seeks to define unique and evolutionarily conserved features of canine immune response pathways and determine how these pathways initiate, sustain, moderate, and resolve immune responses in dogs.
Active Grants:
| 03209 | Discovery of Major Antigenic Determinants of Antibody Responses to Colonizing and Infecting Canine Staphylococcus pseudintermedius |
| 03212-A | Wolbachia-targeting qPCR for Detection of Heartworm Infection in Dogs |
| 03147 | Improving Treatment of Canine Blastomycosis through Therapeutic Drug Monitoring |
| 03137 | Targeted Next Generation Sequencing Panel for Comprehensive Testing for Reproductive and Neurologic Pathogens of Dogs |
| 03087 | Epidemiology of Trypanosoma cruzi and Other Vector-borne Pathogens in Hunting Dogs in Virginia and West Virginia |
| 03118 | MicroRNAs as Novel Fluid Biomarkers of Rabies in Naturally Infected Dogs |
| 03090 | Leishmaniasis in Imported Dogs |
| 03083-A | Investigation into the Prevalence and Clinical Significance of Vector-borne Pathogen Coinfections in a Population of Trypanosoma cruzi-infected Dogs from Texas |
| 03169 | Characterization of Hookworm Resistance in Dogs with a Novel Diagnostic Test for Early Intervention |
| 02983 | Enhanced Detection and Characterization of Spotted Fever Group Rickettsia Species in Dogs and Ticks with Focus on a Novel Rickettsia Species Infecting Clinically Ill Dogs in the U.S. |
Previously Awarded Grants:
| 02986 | Catechol O-Methyltransferase as a Molecular Drug Target in Heartworm |
| 02980 | Canine Systemic Insecticides as a Novel Intervention to Protect Dogs from Triatomine Insect Vectors of Chagas Disease |
| 02841 | Antigen Discovery for an Improved Serologic Diagnostic of Trypanosoma cruzi Infection in Dogs |
| 02838 | Standardization of rLiNTPDase2 and Derived Chimeras as Antigens on Immunochromatographic Assay for Diagnosis of Canine Visceral Leishmaniasis |
| 02404-A | The Impact of Lidocaine Administration on Natural Killer Cell Populations in Canine Sepsis |
| 02821-A | Investigating the Role of Aedes aegypti in Dog Heartworm Transmission in Communities along the U.S.-Mexico Border |
| 02681-A | Analysis of Canine Herpesvirus Isolates Using Next-Generation Sequencing |
| 02408 | Predicting the Outcome of Coccidioidomycosis in Naturally Infected Dogs |
| 02633 | Validation and Diagnostic Performance of a Novel Monoclonal Antibody based Histoplasma Urine Immunoassay in Dogs with Histoplasmosis |
| 02448 | Canine Chagas Disease: Characterizing Cardiac Abnormalities, Vector Infection and Control Strategies, and Parasite Strains in Kennel Environments |
| 02532-A | Canine Influenza: Occurrence, Spatial and Temporal Trends and Identifying Modifiable Factors to Reduce Transmission at Events in the United States |
| 02458-A | A Laboratory Test for Detecting Drug Resistance in Canine Heartworm Disease |
| 02380-A | Estimating Prevalence and Identifying Risk Factors for Canine Leptospirosis in North America |
| 02407-A | In vitro Efficacy of Nano-sulfur Against Planktonic and Biofilm State of Resistant Bacteria |
| 02647-A | Investigation of Cytokine Biomarkers for the Diagnosis of Canine Tuberculosis |
| 02441 | Evaluation of a New Vaccine for Canine Brucellosis |
| 02404-A | The Impact of Lidocaine Administration on Natural Killer Cell Populations in Canine Sepsis |
| 02461-A | Innate immune response to Leptospira in naturally exposed dogs |
| 02245-MOU | Genetic Predisposition to Avian Tuberculosis in Miniature Schnauzers and Bassets Hounds |
| 01699-A | Preventing Inaccurate Diagnosis of Brucellosis |
| 02299-A | Investigating Recovery of the Skin Microbiota after Surgery |
| 1771 | Defining the Unique Genetic Markers in Dogs That Define Immune Function, Disease Resistance and Tissue Transplantation |
| 1988 | Identification of a Safe Storage Time for Canine Blood Used In the Treatment of Anemia |
| 2002 | Defining the Genetic Basis of Inflammatory Bowel Disease |
| 02180-A | Exploring the Canine Immune System for New Treatments |
The AKC Canine Health Foundation funds research in 23 different Research Program Areas for the health of all dogs. These program areas enable the Foundation to create depth in our research portfolio and help us to be responsive to the health concerns of our constituents.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
