Peer-Reviewed Publications Resulting from CHF-funded Grants
We invite you to learn about publications resulting from the Foundation's investments in research. One way CHF measures success in grantmaking is through the production of peer-reviewed publications. CHF-supported research has been published in 218 different peer-reviewed journals, including Nature Genetics and Science and frequently in journals such as the Journal of Veterinary Internal Medicine, Animal Genetics and the American Journal of Veterinary Research. By consistently funding the most innovative research, the AKC Canine Health Foundation is realizing both small milestones and major breakthroughs in canine health.
You may search the complete list of peer-reviewed publications by research program area, breed and/or disease associated with the grant.
To browse publications by year you may also wish to view our Impact Report.
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Grant Number: 03137 Research Program Area: Immunology and Infectious Disease |
Targeted Next Generation Sequencing Panel for Comprehensive Testing for Reproductive and Neurologic Pathogens of Dogs None at this time. |
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Grant Number: 02284-A Research Program Area: Tick-Borne Disease Initiative |
Lyme Disease in Dogs: Prevalence, Clinical Illness, and Prognosis None at this time. |
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Grant Number: 1604 Research Program Area: Immunology and Infectious Disease |
Antibody Response and Duration of Immunity in Dogs Vaccinated with Attenuated Canine Distemper Virus, Canine Adenovirus Type 2 and Canine Parvovirus Vaccines from Commercial Sources None at this time. |
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Grant Number: 02147 Research Program Area: Cardiology |
Use of MicroRNA Profiles in the Serum of Dogs for Early Diagnosis of Mitral Valve Disease and Dilated Cardiomyopathy None at this time. |
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Grant Number: 02759-T Research Program Area: Oncology - Hemangiosarcoma |
Reprogramming the Tumor Immune Niche in Canine Hemangiosarcoma Jong Hyuk Kim, Ashley J. Schulte, Aaron L. Sarver, Donghee Lee, Mathew G. Angelos, Aric M. Frantz, Colleen L. Forster, Timothy D O'Brien, Ingrid Cornax, M. Gerard O'Sullivan, Nuojin Cheng, Mitzi Lewellen, LeAnn Oseth, Sunil Kumar, Susan Bullman, Chandra Sekhar Pedamallu, Sagar M. Goyal, Matthew Meyerson, Troy C. Lund, Matthew Breen, Kerstin Lindblad-Toh, Erin B. Dickerson, Dan S. Kaufman, Jaime F. Modiano; Hemangiosarcoma Cells Promote Conserved Host-Derived Hematopoietic Expansion. Cancer Research Communications 2024; https://doi.org/10.1158/2767-9764 |
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Grant Number: 02317 Research Program Area: Oncology - Lymphoma |
The Role of Complex Translocations Associated with TP53 Somatic Mutations for Aiding Prognosis of Canine Diffuse Large B cell Lymphoma None at this time. |
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Grant Number: 02907 Research Program Area: Oncology |
Ultrasound-guided Histotripsy Ablation of Canine Brain Tumors through an Acoustically Transparent Cranial Window Vezza C, Ruger L, Langman M, et al. First-In-DOg HISTotripsy for Intracranial Tumors Trial: The FIDOHIST Study. Technology in Cancer Research & Treatment. 2024;23. doi:10.1177/15330338241285158 |
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Grant Number: 2217 Research Program Area: Oncology, Oncology - Hemangiosarcoma |
A Novel Mechanism to Regulate the Growth of Canine Hemangiosarcoma None at this time. |
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Grant Number: 02636-A Research Program Area: Oncology |
Development of RNA in-situ Hybridization to Identify T Regulatory Cells and their Function within the Tumor Microenvironment of Canine Oral Malignant Melanoma None at this time. |
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Grant Number: 00728-A Research Program Area: General Canine Health |
The Role of Genetics in the Widely Differing Life Spans of the Domestic Dog None at this time. |
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Grant Number: 2031 Research Program Area: Ophthalmology |
Investigation of Candidate Loci for Progressive Retinal Atrophy in the Old English Sheepdog and Papillon Breeds of Dog None at this time. |
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Grant Number: 03143 Research Program Area: Hepatic Disease |
Causative Role of Xenobiotic Exposures in Canine Gallbladder Mucocele Formation None at this time. |
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Grant Number: 02237-A Research Program Area: Oncology |
Capturing Tumor Cells in Canine Blood None at this time. |
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Grant Number: 01660 Research Program Area: Oncology - Osteosarcoma |
Identifying the Genes That Confer Risk for Osteosarcoma
Eyre, Alexander W., Isain Zapata, Elizabeth Hare, James A. Serpell, Cynthia M. Otto, and Carlos E. Alvarez. “Machine Learning Prediction and Classification of Behavioral Selection in a Canine Olfactory Detection Program.” Scientific Reports 13, no. 1 (August 1, 2023): 12489. https://doi.org/10.1038/s41598-023-39112-7. Alvarez, C. E. (2014). Naturally Occurring Cancers in Dogs: Insights for Translational Genetics and Medicine. ILAR Journal, 55(1), 16–45. https://doi.org/10.1093/ilar/ilu010 Clemente-Vicario, F., Alvarez, C. E., Rowell, J. L., Roy, S., London, C. A., Kisseberth, W. C., & Lorch, G. (2015). Human Genetic Relevance and Potent Antitumor Activity of Heat Shock Protein 90 Inhibition in Canine Lung Adenocarcinoma Cell Lines. PLOS ONE, 10(11), e0142007. https://doi.org/10.1371/journal.pone.0142007
Lutful Kabir, F. M., Alvarez, C. E., & Bird, R. C. (2015). Canine Mammary Carcinomas: A Comparative Analysis of Altered Gene Expression. Veterinary Sciences, 3(1). https://doi.org/10.3390/vetsci3010001
Zaldívar-López, S., Rowell, J. L., Fiala, E. M., Zapata, I., Couto, C. G., & Alvarez, C. E. (2017). Comparative genomics of canine hemoglobin genes reveals primacy of beta subunit delta in adult carnivores. BMC Genomics, 18(1). https://doi.org/10.1186/s12864-017-3513-0
Zapata, I., Moraes, L. E., Fiala, E. M., Zaldivar-Lopez, S., Couto, C. G., Rowell, J. L., & Alvarez, C. E. (2019). Risk-modeling of dog osteosarcoma genome scans shows individuals with Mendelian-level polygenic risk are common. BMC Genomics, 20(1), 226. https://doi.org/10.1186/s12864-019-5531-6
Zapata, I., Serpell, J. A., & Alvarez, C. E. (2016). Genetic mapping of canine fear and aggression. BMC Genomics, 17(1). https://doi.org/10.1186/s12864-016-2936-3
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Grant Number: 02658 Research Program Area: Neurology |
Characterization of Sensory Neuronal and Muscle Pathology in Canine Degenerative Myelopathy to Identify Targets for Therapeutic Intervention None at this time. |
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
