02237-A: Capturing Tumor Cells in Canine Blood

Grant Status: Open

Grant Amount: $10,239
Dr. Tracy Stokol, Ph.D., Cornell University
January 1, 2016 - December 31, 2016
Sponsor(s): American Boxer Charitable Foundation, Portuguese Water Dog Foundation
Breed(s): -All Dogs
Research Program Area: Oncology

Abstract

Just like their human owners, many dogs suffer from cancer, which is often malignant, spreading through the body via blood. Once tumors have spread, they usually result in a poor outcome, including death. The tumor cells in circulation (CTCs) can be counted in the blood of people with cancer using immunocapture devices. The number of CTCs in blood can tell the clinician how aggressive the tumor is, its potential to spread, and how long a patient might survive. There is currently no such way of detecting CTCs in our canine companions. Development of an assay for counting CTCs in canine blood would be of tremendous benefit to our canine patients because, from a simple blood test, we could detect hidden tumors and gather information on tumor severity and the likelihood of spread or metastasis. The investigators will test a novel immunocapture microdevice - the GEDI - for counting tumor cells in canine blood. This device can capture CTCs from blood in human patients with various cancers. This study will test its potential to do the same for dogs. In this pilot study, blood samples from healthy dogs will be manipulated to test the ability to count how many added tumor cells are captured by the GEDI device. If the GEDI does capture the tumor cells, the next step will be to determine if the device can capture CTCs from the blood of dogs that are known to have cancer, paving a path to early detection of cancer in dogs.

Publication(s)

None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Make an Investment Today:

  • $40
  • $60
  • $100
  • $250
  • Give Now
Connect With Us:
Get Canine Health News:
Please leave this field empty

© 2016 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software