02217: A Novel Mechanism to Regulate the Growth of Canine Hemangiosarcoma

Grant Status: Open

Grant Amount: $86,206
Dr. Erin B. Dickerson, PhD, University of Minnesota
January 1, 2016 - December 31, 2017
Sponsor(s): American Bouvier des Flandres Club - Bouvier Health Foundation, American German Shepherd Dog Charitable Foundation, Inc., Clumber Spaniel Health Foundation, English Cocker Spaniel Club of America, Greater Swiss Mountain Dog Club of America, Inc., Keeshond Club of America, Labrador Retriever Club, Inc., Saluki Health Research, Inc., Siberian Husky Club of America, Inc., Vizsla Club of America Welfare Foundation
Breed(s): -All Dogs
Research Program Area: Oncology, Oncology - Hemangiosarcoma

Abstract

Hemangiosarcoma is an extremely aggressive cancer that is rapidly fatal in dogs. While the lifetime risk is alarmingly high for some breeds such as Golden Retrievers and German Shepherd Dogs, the disease does not discriminate, and it can strike any dog at any time. Despite considerable efforts by veterinarians and scientists to find effective treatments, the outcome for dogs with hemangiosarcoma has changed very little over the past few decades. Recent evidence provides essential clues into how these tumors grow and progress, generating new ideas for treatment approaches. Such new evidence suggests that hemangiosarcoma cells rely on the metabolism of lipids or fatty acids to supply energy for tissue invasion or continued tumor growth. To obtain these lipids, hemangiosarcomas may take over the metabolic machinery of neighboring cells, forcing them to produce nutrients for the tumor cells to help them proliferate and grow. This study will verify that tumor cells rely on lipid metabolism for growth, and determine if tumor cells alter the metabolism of fat cells to obtain cellular nutrients and accelerate tumor cell lipid metabolism. Identifying and exploiting a novel mechanism that may disrupt this process by inhibiting the interactions between tumor cells and cells in the tumor environment will speed clinical investigations, and ultimately lead to improved outcomes for dogs with this devastating disease.

Publication(s)

None at this time.

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