Oncology Grants

In continuation of CHF’s strong support of canine cancer research, the Oncology Research Program Area remains committed to innovative research that will aid in the discovery of advanced diagnostic technology and therapeutic target identification.

To make sense of the complexity of cancer, new approaches are needed to provide comprehensive characterization of tumors and other canine cancers. These approaches will likely require broad bioinformatic analyses, high throughput methodologies and systems biology tools.

Active Grants:

 02595-A  Defining the Flow Cytometric Characteristics of Normal and Diseased Canine Spleen and Visceral Lymph Nodes
 02643-A  Examination of the Effects of Cannabidiol on Canine Neoplastic Cell Apoptosis/Autophagy and Potential for Chemotherapy Resistance or Sensitivity
 02636-A  Development of RNA in-situ Hybridization to Identify T Regulatory Cells and their Function within the Tumor Microenvironment of Canine Oral Malignant Melanoma
 02446  Development of Genetic Biomarkers to Improve Diagnosis and Treatment of Canine Histiocytic Sarcoma
 02522-A  The Investigation of Lypoxigenase-5 Expression in Canine Normal, Hyperplastic and Neoplastic Urinary Bladder Epithelium
 2489  Tumor-permissive Collagen Signatures in Canine Mammary Gland Tumors: Development of Prognostic Markers and Targeted Therapies for Improved Outcomes
 2487  OX40 Checkpoint Molecule Targeted Antibodies for Cancer Immunotherapy in Dogs
 02500  Immune Targeting of the V600E B-Raf Neoantigen in Canine Urothelial Carcinoma
 02456-A  The Impact of Intravenous Anesthetic Agents on Canine Natural Killer Cell
 02455-A  Identification of genetic mutations in anal sac carcinoma in English Cocker Spaniels

Previously Awarded Grants:

 02405-A  Transcriptome Based Diagnostics in Canine Soft Tissue Sarcoma
 2217  A Novel Mechanism to Regulate the Growth of Canine Hemangiosarcoma
 02237-A  Capturing Tumor Cells in Canine Blood
 02171-MOU  Histiocytic Sarcoma in Bernese Mountain Dogs: Novel Approaches To Treatment
 1826  A Novel Treatment for Brain Tumors Using a One Medicine Approach
 02244-A  Beyond Peto's Paradox with the Geriatric Peromyscus
 01689-A  Increasing the Effectiveness of Radiation Therapy in Treatment of Mast Cell Tumors
 2071  Development of a Therapeutic Brain Tumor Vaccine
 02091-A  Differentiating between Localized and Disseminated Histiocytic Sarcoma in Bernese Mountain Dogs
 02093-A  Sequencing Histiocytic Sarcoma (HS) loci identified by Genetic Association studies in the Bernese Mountain Dog (BMD)
 1843  Further Investigation of the Genes Controlling Canine Leukemia to Properly Diagnose and Control the Disease
 1822  Beyond the Genome: The Intersection of Genes and the Environment in Canine Cancer
 01872-A  Using Ultrasound as a Cost Effective and Non-Invasive Technique for Early Diagnosis of Solid Tumors
 1557  Narrowing the Search for the Genetic Basis of Histiocytic Malignancies
 1633  Novel Therapy for Melanoma, Lymphoma, Meningioma and Nephroblastoma
 1577  Identifying the Genes Conferring Risk for Transitional Cell Carcinoma
 1426  Personalized Medicine for the Treatment of Canine Mast Cell Tumors
 01914-A  Defining the Genes That Contribute to the Development of Soft Tissue Sarcomas
 01669-A  Determining the Role of Bacterial Infection in Complications after Chemotherapy
 01861-A  Preventing Heart Damage during Chemotherapy through Early Detection of Cardiotoxicity
 01683-A  Improving Resection of Tumors through Enhanced Imaging
 01703-A  Enhancing Natural Anti-Tumor Immune Responses during Chemotherapy
 01929-A  Arginine Dependence: Identification of Cancer's Achilles Heel
 01686-A  Identifying Drugs That Will Kill Cancer Stem Cells
 01912-A  Enhancing the Safety and Efficacy of Anti-Cancer Drugs in Dogs

The AKC Canine Health Foundation funds research in 23 different Research Program Areas for the health of all dogs. These program areas enable the Foundation to create depth in our research portfolio and help us to be responsive to the health concerns of our constituents.

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