In continuation of our strong support of canine cancer research, the Oncology Research Program remains committed to the promotion of innovative research that will aid in the discovery of advanced diagnostic technology and therapeutic target identification.
There is new evidence that we must deepen our understanding of the heterogeneous nature of tumors in order to make progress in the battle against canine cancer. Included in tumor heterogeneity is the presence of cancer stem cells which are thought to support tumor progression, metastasis and impair susceptibility to chemotherapeutic intervention. In order to make sense of the complexity of cancer, new approaches are needed to provide comprehensive characterization of tumors. These approaches will likely require broad bioinformatic analyses, high throughput methodologies and systems biology tools.
Recently funded grant titles:
- Validation of a general method for enrichment of canine cancer stem cells
- Using Ultrasound as a Cost Effective and Non-Invasive Technique for Early Diagnosis of Solid Tumors
- Using Enhanced Imaging to Evaluate Tumor Margins for Canine Mammary Cancer and Soft Tissue Sarcoma
- The Role of Complex Translocations Associated with TP53 Somatic Mutations for Aiding Prognosis of Canine Diffuse Large B cell Lymphoma
- Targeting the Cell's Activation Machinery to Halt Tumor Metastasis in Canine Osteosarcoma
- Targeting the Cancer Epigenome: The Effect of Specific Histone Lysine Methyltransferase Inhibition in Canine B-Cell Lymphoma
- Targeting iNOS in Canine Oral Melanoma
- Serum Antibody Reactivity Profiling for Canine Lymphoma Detection and Monitoring
- Sequencing Histiocytic Sarcoma (HS) loci identified by Genetic Association studies in the Bernese Mountain Dog (BMD)
- Preventing Heart Damage during Chemotherapy through Early Detection of Cardiotoxicity
- Positional Cloning of the Gene(s) for Gastric Cancer in the Chow Chow
- Pilot Study to Assess Folate Receptor Expression in Canine High-Grade Multicentric Lymphoma
- Personalized Medicine for the Treatment of Canine Mast Cell Tumors
- Novel Therapy for Melanoma, Lymphoma, Meningioma and Nephroblastoma
- Narrowing the Search for the Genetic Basis of Histiocytic Malignancies
- Mutation Detection and Functional Analysis of Multiple Loci for Osteosarcoma
- MicroRNA Profiling and MicroRNA-Based Treatment of Canine Cancers
- Mechanistic Relationship of IL-8 in Cell Proliferation and Survival of Canine Hemangiosarcoma
- Isolation and Characterization of Tumor Initiating Cells in Canine Osteosarcoma Cell Lines
- Investigating a Biomarker and Novel Therapeutic Target for Canine Diffuse Large B Cell Lymphoma
The AKC Canine Health Foundation funds research in 18 different Research Program Areas. These program areas enable the Foundation to create depth in our research portfolio and help us to be responsive to the health concerns of our constituents.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.