In continuation of our strong support of canine cancer research, the Oncology Research Program remains committed to the promotion of innovative research that will aid in the discovery of advanced diagnostic technology and therapeutic target identification.
There is new evidence that we must deepen our understanding of the heterogeneous nature of tumors in order to make progress in the battle against canine cancer. Included in tumor heterogeneity is the presence of cancer stem cells which are thought to support tumor progression, metastasis and impair susceptibility to chemotherapeutic intervention. In order to make sense of the complexity of cancer, new approaches are needed to provide comprehensive characterization of tumors. These approaches will likely require broad bioinformatic analyses, high throughput methodologies and systems biology tools.
Recently funded grant titles:
- Mechanistic Relationship of IL-8 in Cell Proliferation and Survival of Canine Hemangiosarcoma
- Isolation and Characterization of Tumor Initiating Cells in Canine Osteosarcoma Cell Lines
- Investigating a Biomarker and Novel Therapeutic Target for Canine Diffuse Large B Cell Lymphoma
- Integrating Cutting Edge Science with Scientific Training to Defeat Hemangiosarcoma
- Innovations in Prevention, Diagnosis, and Treatment of Cancer - Goldens Lead the Way
- Increasing the Effectiveness of Radiation Therapy in Treatment of Mast Cell Tumors
- Improving Resection of Tumors through Enhanced Imaging
- Identifying the Genes That Confer Risk for Osteosarcoma
- Identifying the Genes Conferring Risk for Transitional Cell Carcinoma
- Identifying the cause of drug resistance in canine lymphoma
- Identifying Growth Factors That Promote the Spread of Osteosarcoma
- Identifying Drugs That Will Kill Cancer Stem Cells
- Identification of genetic mutations in anal sac carcinoma in English Cocker Spaniels
- Identification and Characterization of a Canine Derived Single Chain Antibody that Binds and Neutralizes Canine VEGF
- Histiocytic Sarcoma in Bernese Mountain Dogs: Novel Approaches To Treatment
- Harnessing a Dog's Own Immune System to Kill Lymphoma Tumor Cells
- Genetic Risk Factors for Canine T zone Lymphoma
- Genetic Background and the Angiogenic Phenotype in Cancer
- Genetic and Environmental Risk for Lymphoma in Boxer Dogs
- Further Investigation of the Genes Controlling Canine Leukemia to Properly Diagnose and Control the Disease
The AKC Canine Health Foundation funds research in 18 different Research Program Areas. These program areas enable the Foundation to create depth in our research portfolio and help us to be responsive to the health concerns of our constituents.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.