In continuation of our strong support of canine cancer research, the Oncology Research Program remains committed to the promotion of innovative research that will aid in the discovery of advanced diagnostic technology and therapeutic target identification.
There is new evidence that we must deepen our understanding of the heterogeneous nature of tumors in order to make progress in the battle against canine cancer. Included in tumor heterogeneity is the presence of cancer stem cells which are thought to support tumor progression, metastasis and impair susceptibility to chemotherapeutic intervention. In order to make sense of the complexity of cancer, new approaches are needed to provide comprehensive characterization of tumors. These approaches will likely require broad bioinformatic analyses, high throughput methodologies and systems biology tools.
Recently funded grant titles:
- Further Investigation of the Genes Controlling Canine Leukemia to Properly Diagnose and Control the Disease
- Expression and distribution of Receptor Activator of Nuclear factor kB Ligand (RANK-L) and its receptor RANK in canine osteosarcoma
- Evaluation of a Novel Drug to Treat Canine Cutaneous Lymphoma
- Evaluating a Safer, Less Toxic Radiation Therapy in the Treatment of Lymphoma
- Ensuring That Emerging Stem Cell Treatments Do Not Activate or Exacerbate Cancer in Dogs
- Enhancing the Safety and Efficacy of Anti-Cancer Drugs in Dogs
- Enhancing Natural Anti-Tumor Immune Responses during Chemotherapy
- Enhanced Killing of Malignant Histiocytosis with a Novel Combination of Anti-Tumor Drugs
- Enhanced Hemangiosarcoma Therapy Using a Novel Combination of Drugs That Target Tumor Proliferation
- Disrupting the Differentiation of Cancer Stem Cells to Prevent the Spread of Hemangiosarcoma
- Discovery of Novel Micro-Ribonucleic Acids for Diagnosis and Prognosis of Canine Hemangiosarcoma
- Discovery of Biomarkers to Detect Lymphoma Risk, Classify For Treatment, and Predict Outcome in Golden Retrievers
- Discovering Peptide Targets for Development of Adoptive Cell Therapy for Peripheral T-Cell Lymphoma
- Differentiating between Localized and Disseminated Histiocytic Sarcoma in Bernese Mountain Dogs
- Development of a Therapeutic Brain Tumor Vaccine
- Developing the Use of a Novel Imaging Technique to Define a Dog's Potential Responsiveness to Chemotherapy
- Determining the Role of Bacterial Infection in Complications after Chemotherapy
- Defining the Genes That Contribute to the Development of Soft Tissue Sarcomas
- Defining the Anti-Tumor Activity of Monocytes in Osteosarcoma
- Clinical Advancement of a Cancer Vaccine in Dogs
The AKC Canine Health Foundation funds research in 18 different Research Program Areas. These program areas enable the Foundation to create depth in our research portfolio and help us to be responsive to the health concerns of our constituents.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.