Oncology - Osteosarcoma Grants

The Oncology - Osteosarcoma Research Program Area remains a focus of the AKC Canine Health Foundation through support of research into the pathophysiology of osteosarcoma, as well as the genetic basis and identification of potential therapeutic drugs.

Active Grants:

 02768 Defining the Functional Consequences and Therapeutic Vulnerability of Dystrophin Alterations in Canine Osteosarcoma
 02773 Histotripsy for Treatment of Canine Appendicular Osteosarcoma
 02782 Genetic Contribution to Early-onset Osteosarcoma
 01660 Identifying the Genes That Confer Risk for Osteosarcoma

Previously Awarded Grants:

 02642-A NF-kappaB Inactivation Enhances Apoptosis in Canine Osteosarcoma Cells
 02215 A Cancer Vaccine for Canine Osteosarcoma
 1806 A Novel Virus-Based Anti-Tumor Treatment for Canine Osteosarcoma
 01949-A Targeting the Cell's Activation Machinery to Halt Tumor Metastasis in Canine Osteosarcoma
 01903-A Defining the Anti-Tumor Activity of Monocytes in Osteosarcoma
 01726-A Identifying Growth Factors That Promote the Spread of Osteosarcoma
 01672-A Isolation and Characterization of Tumor Initiating Cells in Canine Osteosarcoma Cell Lines
 01704-A Expression and distribution of Receptor Activator of Nuclear factor kB Ligand (RANK-L) and its receptor RANK in canine osteosarcoma
 01317 Mutation Detection and Functional Analysis of Multiple Loci for Osteosarcoma
 01503-A Rational Development of Targeted Therapy - Aurora Kinase Inhibition in Osteosarcoma
 01542-A The Effects of Baicalein on Canine Osteosarcoma Cells
 00947B Heritable and Sporadic Genetic Lesions in Canine Osteosarcoma
 982 Evaluation of Efficacy of Fasaret in Dogs with Osteosarcoma
 976 Investigating the Role of STAT3 Activation in Canine Osteosarcoma
 01192-A Metabolism and Action of Gemcitabine in Canine Osteosarcoma Cell Lines
 778 Role of Regulatory T Cells in Dogs with Osteosarcoma
 00757A Hereditary Mutations in Genes Associated with Osteosarcoma in Large Dog Breeds
 01046-A The Relevance of Ezrin in the Metastatic Progression of Canine Osteosarcoma
 00757B Hereditary Mutations in Genes Associated with Osteosarcoma in Large Dog Breeds
 01178-A Radiosensitization of Canine Osteosarcoma with Rapamycin
 00826-A Percutaneous Cryoablation in Canine Osteosarcoma
 00373A Mapping Genes Associated with Osteosarcoma in Large Dog Breeds
 00373B Mapping Genes Associated with Osteosarcoma in Large Dog Breeds
 2629 Clinical and Immunological Outcomes in Dogs with Osteosarcoma Treated with Intratumoral Interleukin-12 Microspheres

The AKC Canine Health Foundation funds research in 23 different Research Program Areas for the health of all dogs. These program areas enable the Foundation to create depth in our research portfolio and help us to be responsive to the health concerns of our constituents.

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