Kidney and Urological Disease Grants

The AKC Canine Health Foundation supports basic science discovery and clinical research into the treatment of renal and urologic disorders through the Kidney and Urological Disease Research Program Area. This program supports research into the pathophysiology of disease, the identification of unique/emerging risk factors for the development of renal disease, genetic/epigenetic/proteomic/metabolomic factors associated with disease development, predictors (biomarkers) of kidney damage and recovery, and identification of potential therapeutic drugs that reduce the pathology associated with disease.

Active Grants:

 02556-MOU Identification of the Molecular Genetic Cause for Cystinuria in Irish Terriers
 02437-MOU Characterization of Renal Disease in American Boxer Dogs
 02263-MOU Characterization of Kidney Disease in Dalmatians
 02152 Translation of MicroRNA into an Early Diagnostic Test for Chronic Kidney Disease
 02066 Identification of Novel Biomarkers and Therapeutic Targets for Chronic Kidney Disease in Dogs
 01844 Treatment of Urinary Incontinence with Multipotent Muscle Cells: A Regenerative Medicine Approach to a Common Canine Health Problem

Previously Awarded Grants:

 02110-A Investigating the Effects of an Infusion of Fenoldopam on Kidney Function to Improve Outcomes of Acute Kidney Injury Patients
 1766 Identification and Validation of the Genes That Define Abnormal Development of the Kidney in Dogs
 1658 Early Detection of Chronic Kidney Disease to Prevent Kidney Damage
 01354-A Heritability of Calcium Oxalate Urolithiasis in Miniature Schnauzers
 01535-A DNA Sequence Examination of a Gene Region Associated with Mastiff Cystine Stone Formation
 01363-A Comparison of Vitamin B6 levels in a Breed (the Bichon Frise dog) Predisposed to Calcium Oxalate Stones versus Healthy Dogs
 01388-A Validation of a SNP Haplotype Associated with Mastiff Cystine Stone Formation for Use in Genetic Testing
 919 Molecular Genetic Characterization of Canine Cystinuria for the Development of Carrier Tests
 386 Elucidation of the Genetic Defect in Familial Renal Disease in the Norwegian Elkhound
 639 Molecular Genetic Characterization of Canine Cystinuria for the Development of Carrier Tests
 00873-A Preliminary Disease Gene Mapping of Juvenile Renal Dysplasia in the Boxer Dog
 00801-A Characterization of the Mutation Responsible for Fanconi Syndrome in Basenjis
 248 Use of an Artificial Urethral Sphincter in Dogs with Urethral Sphincter Mechanism Incompetence
 460 Measurement of Acute Phase Reactants as a Diagnostic Tool in Shar-Pei Fever
 2458 Molecular Genetic Characterization of Canine Cystinuria for the Development of Carrier Tests
 00311-A A Continued Molecular Genetic Study of Fanconi Syndrome in Basenjis
 2462 Molecular Genetic Study of Fanconi Syndrome in Basenjis
 2020 Inheritance of Urinary Stone Formation in the Dalmatian
 1946 Molecular Genetic Characterization of Canine Cystinuria for the Development of Carrier Tests
 1858 Identifying the Genetic Causes of Renal Dysplasia in Shih Tzu, Lhasa Apso and Soft Coated Wheaten Terriers
 1276 Molecular Genetic Characterization of Canine Cystinuria for the Development of Carrier Tests
 1301 Development of DNA Markers for Shar-Pei Fever
 1270 Hereditary Nephritis in English Cocker Spaniels
 1445 Evaluation of the Canine HNF1 and HNF2 Genes as Candidates for the Locus Causing Fanconi Syndrome in Basenjis

The AKC Canine Health Foundation funds research in 23 different Research Program Areas for the health of all dogs. These program areas enable the Foundation to create depth in our research portfolio and help us to be responsive to the health concerns of our constituents.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

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