Displaying results 51 - 60 of 68 items found.
51. AKC Canine Health Foundation Announces 2015 National Parent Club Canine Health Conference August 7-9
(Web Page; Thu Aug 27 20:24:00 CDT 2015)
Description: The AKC Canine Health Foundation is pleased to announce it is hosting the 2015 National Parent Club Canine Health Conference August 7-9.
52. Laura Bryan, DVM
(Web Page; Wed Aug 21 07:52:00 CDT 2019)
Description: Laura Bryan is the 2014 AKC Canine Health Foundation Clinician-Scientist Fellow from Texas A&M University.
53. AKC Canine Health Foundation Holds its First Virtual National Parent Club Canine Health Conference
(Web Page; Sat Aug 14 15:47:00 CDT 2021)
Description: The AKC Canine Health Foundation hosts its National Parent Club Canine Health Conference this weekend, August 13-15, virtually for the first time in the conference’s 24-year history
54. AKC Canine Health Foundation Receives Champion Sponsorship from The Kennel Club of Philadelphia
(Web Page; Thu Feb 17 15:34:00 CST 2022)
Description: The AKC Canine Health Foundation (CHF), a non-profit organization dedicated to advancing the health of all dogs, announces a Champion Sponsor level gift from The Kennel Club of Philadelphia.
(Web Page; Tue Jun 04 13:33:00 CDT 2024)
Description:
Dermatomyositis (DMS) is a chronic inflammatory and autoimmune disorder affecting primarily skin and muscle in both humans and dogs. Familial canine DMS is mainly described in predisposed breeds, such as Collies and Shetland Sheepdogs, and is characterized by severe inflammatory lesions leading to skin scarring with disfiguration, increased morbidity and decreased quality of life. Full clinical remission of DMS skin lesions can be difficult to achieve, reflecting a poor understanding of the pathogenesis of skin lesions in this disease. The transcriptome (gene expression analysis) investigation of human DMS tissues has revolutionized the understanding of the molecular fingerprint of DMS, further defining pathogenic immune pathways and identifying disease-specific biomarkers. Recently, a novel mechanism-based treatment using Janus kinase (JAK) inhibitors has led to a significant clinical and molecular improvement in refractory cutaneous DMS in humans. Oclacitinib is a safe and well-tolerated JAK inhibitor that has been used for the treatment of allergic dermatitis in dogs; however, the therapeutic effect of oclacitinib on canine immune-mediated diseases, such as DMS, has not been investigated. The main objective of this study is to perform a large-scale molecular signature analysis of canine familial DMS. Investigators hypothesize that integrating deep sequencing-based transcriptome profiling with systems biology analysis will identify novel pathogenic pathways and inflammatory biomarkers as canine DMS disease drivers, with potential for the development of novel targeted therapeutics. Furthermore, they will evaluate the effect of oclacitinib, a novel veterinary JAK inhibitor, on the modulation of the cutaneous DMS clinical signs in dogs. These results may suggest that JAK inhibition has the potential to reverse canine DMS pathomechanisms, opening the door to a new era of targeted treatment for this debilitating inflammatory skin disease.
Funding for the research is provided through the collaborative efforts and generosity of the Collie Health Foundation and American Shetland Sheepdog Association. The AKC Canine Health Foundation supports the funding of this effort and will oversee grant administration and scientific progress.
Learn how you can participate in this research!
56. Diet-Related Dilated Cardiomyopathy in Dogs
(Web Page; Wed Jan 15 08:05:00 CST 2020)
Description: Several research studies are underway to explore factors influencing the apparent increase in incidence of diet-related dilated cardiomyopathy in dogs, including a multi-institutional, prospective study supported by the AKC Canine Health Foundation (CHF).
57. AKC Canine Health Foundation Awards 2021 Clinician-Scientist Fellowships
(Web Page; Tue Dec 01 13:46:00 CST 2020)
Description: The AKC Canine Health Foundation awards three Clinician-Scientist Fellowships for 2021 to encourage and support the next generation of canine health researchers.
58. AKC Canine Health Foundation Celebrates $3.29 Million in Canine Health Grants Awarded in 2020
(Web Page; Mon Dec 21 12:45:00 CST 2020)
Description: The AKC Canine Health Foundation celebrates continued growth in its canine health investments, awarding $3.29 million in 53 new grants during 2020.
59. AKC Canine Health Foundation Awards 2022 Clinician-Scientist Fellowships
(Web Page; Wed Nov 24 13:46:00 CST 2021)
Description: The AKC Canine Health Foundation (CHF), a non-profit organization dedicated to advancing the health of all dogs, awards three Clinician-Scientist Fellowships for 2022.
60. AKC Canine Health Foundation Awards 2023 Clinician-Scientist Fellowships
(Web Page; Thu Dec 08 08:18:00 CST 2022)
Description: The AKC Canine Health Foundation (CHF), a non-profit organization dedicated to advancing the health of all dogs, awards four Clinician-Scientist Fellowships for 2023.
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
