Displaying results 31 - 40 of 61 items found.

31. 2002 Dog Owners and Breeders Symposium Summaries

(File; Tue Nov 16 07:43:00 CST 2010)

Dog Owners and Breeders SymposiumJuly 27, 2002University of FloridaCollege of Veterinary MedicineSponsored by*Cancer Treatment Update*Endocrine Update*Neurological Emergencies*Ten Steps to Breeding Better Dogs*Ear Disease Update*Canine P...

Description: Summaries of the presentions made at the 2002 Dog Owners and Breeders Symposium at the University of Florida College of Veterinary Medicine.

32. Tufts Canine and Feline Breeding and Genetics Conference Summaries

(File; Fri Nov 12 09:59:00 CST 2010)

September 30 – October 1, 2005Tufts' Canine and FelineThank Breeding you to our generoand us Genetics sponsorsSturbridge, MAConferenceTufts’ Canine and Feline Breeding and Genetics ConferenceSturbridge, MassachusettsSeptember 30 – Oc...

Description: Presenation summaries from the 2005 Tufts Canine and Feline Breeding and Genetics Conference.

33. Microbiology and Histopathological Features of Canine Acral Lick Dermatitis

(Web Page; Wed Aug 21 09:05:00 CDT 2019)

None at this time.

Description: Acral lick dermatitis is a common, frustrating disease of dogs, characterized by chronic, obsessive licking to the point of self-trauma. Most past research has focused on behavioral problems, such as boredom and anxiety. However, many other causes can start the process Regardless of initiating cause, nearly all lesions become deeply infected by bacteria, worsening disease and perpetuating stimulus to lick Complete resolution requires both identification of initiating cause and successful treatment of secondary infection. Current literature suggests routine use of common antibiotics, such as Cephalexin, to treat these lesions; however, dermatologists have observed an increase in resistant bacteria, no longer susceptible to suggested antibiotics. No publication describes presence of resistant bacteria or need for culture of acral lick dermatitis. If treatment is based on current literature, then failure is likely. The purpose of the study is to better characterize the histopathological and microbiological features of acral lick dermatitis. The results should aid in the treatment of this frustrating disease. Thirty client-owned dogs with acral lick dermatitis will be enrolled. Tissue biopsies will be collected for histopathology, bacterial, and fungal culture. Surface samples will be submitted to determine if differences exist between superficial and deep cultures. Breed predispositions will also be determined.

34. Treatment of Canine Atopic Dermatitis with a Novel Immune Modulating Vaccine

(Web Page; Wed Aug 21 09:05:00 CDT 2019)

None at this time.

Description: One of the most frustrating and common canine dermatological conditions is atopic dermatitis, an immune mediated disorder. Unfortunately, there are few effective therapies and many dogs require prolonged administration of steroids and other immunosuppressive drugs. In addition, current therapies often have a host of side effects and compliance to therapy can be challenging for most owners. Immune suppression is only partially effective, prompting newer approaches in selective immune modulation. Immune modulation holds the promise of effective and safe treatment without the side effects or complications of traditional therapy. A new vaccine has been developed that proposes to reduce the severity of canine atopic dermatitis. This vaccine re-adjusts the immune system without causing immune suppression and proposes to be both cost effective and safe. The vaccine has already entered trials in veterinary medicine with encouraging results. If successful, this vaccine would be a cost effective and safe approach to treating this common disease.

35. Screening of Healthy Dogs and Dogs with Chronic Allergic Dermatitis for Colonization of the Skin by Methicillin-Resistant Strains of Staphylococci

(Web Page; Wed Aug 21 09:05:00 CDT 2019)

None at this time.

Description: Bacterial skin infection (pyoderma) is the most common skin disease occurring in dogs. Greater than 90 percent of pyoderma in dogs is caused by Staphylococcus spp. bacteria, and canine skin is more susceptible to staphylococcal infections than the skin of human beings or any other domestic species. In dogs with allergic skin diseases (which may represent up to 15 percent of the total canine population), staphylococcal skin and ear canal infections are especially common. Breeds with the greatest relative risk (propensity to develop allergic skin disease) include Golden and Labrador Retrievers, German Shepherds, English, Irish and Gordon Setters, Boxers, Miniature Schnauzers, Dalmatians, Lhasa Apsos, Shiba Inus, Chinese Shar-Pei, and many terrier breeds (Scotties, Westies, Cairns, Yorkies, and Wirehaired Fox Terriers among others). Historically, successful treatment of staphylococcal infections with oral and/or topical antibiotics have been achieved, however the evolution of multi-drug resistant strains of staphylococci has resulted in less predictable outcomes for a large portion of affected patients. The healthy skin of dogs is naturally colonized by S. intermedius, but S. aureus and S. schleiferi are thought to be only transient inhabitants of canine skin that are usually associated with overt infections. However, in light of the increased frequency of isolation of methicillin-resistant S. aureus and S. schleiferi from canine infections, it is possible that the status of resident bacterial colonization of dogs has changed. We propose to screen healthy dogs with normal skin, and dogs with chronic allergic dermatitis, for methicillin-resistant strains of these three species of staphylococci. This epidemiological survey will serve to educate veterinarians and the dog-owning public of the current status of canine staphylococcal carriage, explore its implications for canine and public health, and fulfill the need for a more scientific approach to the diagnosis and treatment of canine pyoderma.

36. Development of Anti-IgE Peptide for Treatment of Canine Allergy

(Web Page; Tue May 04 15:07:00 CDT 2021)

Hammerberg, B., Olivry, T., & Orton, S. M. (2001). Skin mast cell histamine release following stem cell factor and high-affinity immunoglobulin E receptor cross-linking in dogs with atopic dermatitis. Veterinary Dermatology, 12(6), 3...

Description:

Treatment of chronic allergic diseases in dogs, often seen as recurring dermatitis, frequently results in less than optimal outcomes. When the disease can be linked to exposure to specific allergens, such house dust mites, desensitization injections can be effective in some individuals when carried out over an extended time; however, most cases are not resolved by desensitization and require a combination of allergen avoidance and anti-inflammatory drugs. The prolonged use of these drugs, such as corticosteroids, can result in severe side effects. These same challenges exist for human allergy suffers, but recently there has been a major breakthrough in the development of a new, safe and effective therapy using a monoclonal antibody that specifically binds and neutralizes human IgE that is responsible for activating inflammation-producing cells. This new product is called Xolair� and it has been used safely by millions of allergy patients for more than 5 years. Our laboratory has developed a monoclonal antibody that specifically binds canine IgE in the same manner as the monoclonal antibody used to develop Xolair�. There are two obstacles remaining in providing the canine equivalent to Xolair� for treatment of allergies in dogs and they are the Objectives of this proposal: 1. Modifying the monoclonal antibody to reduce the dog's natural response to clear this protein; and, 2. Developing cost effective production of the modified antibody. Our Approach is to: 1. Generate a single chain recombinant peptide from the IgE-binding region of our canine IgE-specific monoclonal antibody that is small in size and of limited antigenic potential; and 2. Develop a transgenic plant (eg. tobacco) containing the gene for this recombinant peptide using well established techniques that will allow production of the therapeutic peptide in kilogram quantities. The expected outcome will be to provide a new, safe and highly effective treatment option for canine allergic diseases that is affordable to use for maintenance therapy.

37. Evaluation of the Serum and Cutaneous Levels of Chemokines in Atopic Dogs

(Web Page; Mon Feb 28 09:57:00 CST 2022)

Santoro, D., Archer, L., & Chong, E. (2022). Evaluation of cutaneous and circulating (serum and exosomes) levels of chemokines (CCL17, CCL22, CCL27 and CCL28) in atopic dogs and their correlation with severity of the disease. Veterin...

Description:

Atopic dermatitis (AD) is very common in dogs and children. AD is affected by complex and yet incompletely understood interactions between many factors such as environment, different types of white blood cells, and immunological factors. Chemokines are one of the factors that are used to modulate the immune system, leading to AD. Specific inflammatory chemokines were chosen for this study based on their relevance to AD from previously published studies in human and veterinary medicine. This study will evaluate the levels of these chemokines in blood, exosomes (a small pouch from cells that is used for communication between cells via blood), and skin of dogs with AD. In addition, the investigators will look for a correlation between the levels of these chemokines and severity of AD with a long-term goal to find a potential tool for monitoring and treating AD in dogs and humans.

38. CHF Awards 21 Research Grants for 2012

(Web Page; Tue Nov 15 08:32:00 CST 2011)

The AKC Canine Health Foundation (CHF) is committing more than $1.5 million in 2012 on research grants to help dogs live longer, healthier lives. CHF approved 21 OAK grants to 14 research institutions and universities to conduct researc...

Description: The AKC Canine Health Foundation (CHF) is committing more than $1.5 million in 2012 on research grants to help dogs live longer, healthier lives. CHF approved 21 OAK grants to 14 research institutions and universities to conduct research covering canine health issues such as cataracts, carcinoma, dermatitis, epilepsy, liver disease, lymphoma, melanoma, and osteosarcoma.

39. Basophil/Mast Cell Response to Lectins as a Predictor for Risk of Allergic Disease in Genetically Susceptible Dogs

(Web Page; Wed Aug 21 09:05:00 CDT 2019)

None at this time.

Description: Atopic dermatitis or skin allergies is a chronic debilitating disease that is widely distributed among the breeds of dogs. This inherited disease is listed as a high research priority for the following breeds: Bichon Frise, Boston Terrier, Bull Terrier, Cairn Terrier , Dalmatian, Vizsla, Welsh Terrier and West Highland White Terrier. The skin mast cell and circulating basophil are the cells mainly responsible for itching and skin damage seen in atopic dermatitis. This laboratory has just recently discovered that mast cells from atopic dogs release significantly more of the inflammatory mediator, tumor necrosis factor alpha (TNF-?), than normal dog mast cells when stimulated with lectins that bind glycoproteins on the surface of mast cells. If there is an inherited difference in how surface glycoproteins signal release of TNF-?, then knowledge of the molecular basis for this difference will lead to being able to identify dogs that will have a higher risk of developing atopic dermatitis. To accomplish this, atopic and nonatopic dogs will be compared with regard to the identity and quantity of the cell surface glycoproteins on basophils that are responsible for signaling immediate TNF-? release stimulated by lectins.

40. Studies of the Host (Canine) Immune Response to the Opportunistic Pathogen Malassezia pachydermatis

(Web Page; Tue Aug 27 14:52:00 CDT 2019)

Morris, D. O., Clayton, D. J., Drobatz, K. J., & Felsburg, P. J. (2002). Response to Malassezia pachydermatis by peripheral blood mononuclear cells from clinically normal and atopic dogs. American Journal of Veterinary Research, 63(3...

Description:

This study confirmed that the immune system of allergic dogs recognizes a specific yeast as a contributor to allergies that the dog's body is mounting an allergic response to the yeast, not just reacting to a yeast infection. The yeast, Malassezia pachydermatis, is present in many dogs with skin allergies, causing itching, infection and sometimes licking to the point of self-mutilation. The most common symptoms of the yeast are ear canal infections and paw licking. Dogs with the yeast allergy can react to a quantity of yeast that would be considered within normal limits for healthy dogs. This discovery provides evidence and hope that it might be possible to manage that allergic reaction through the development of yeast-specific allergy shots, rather than relying on anti-fungal medications, which carry a possibility of side effects and don't stop the allergic reaction from recurring.

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