03124: Synbiotic-IgY modulates microRNA expression and microbiota in dogs with chronic enteropathy
Grant Status: Open
Abstract
Chronic intestinal disease is a common cause for persistent diarrhea, vomiting, and weight loss in dogs.Recent scientific evidence has documented that disturbances in intestinal bacterial composition are associated with gut inflammation. Probiotics are live microbial cultures that are thought to restore normal microbial balance in the intestines. While studies have shown that probiotics are beneficial in dogs with gastroenteritis, how probiotics mediate their effects in the host is not known. Using archived intestinal biopsies collected from a previous probiotic trial, researchers will investigate the molecular mechanisms that influence probiotic actions. The team hypothesizes that probiotics regulate small molecules in the body (microRNAs) to improve canine health by reducing intestinal inflammation and promoting healthful bacterial composition in the intestines. Results from this study will provide a greater understanding of how probiotics work to maintain gut health and mitigate or prevent chronic gastrointestinal diseases in dogs.
Publication(s)
None at this time.
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Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
