02880: Enhanced Surgical Margin Imaging with Polarization-sensitive Optical Coherence Tomography in Canine Soft Tissue Sarcoma and Mammary Tumors

Grant Status: Open

Grant Amount: $49,226
Laura Selmic, BVetMed, MPH; The Ohio State University
June 1, 2021 - May 31, 2023

Sponsor(s):

Breed(s): -All Dogs
Research Program Area: Oncology
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Abstract

Surgery is the most common treatment used for skin and mammary cancer in dogs. Currently, a pathologist determines whether surgery has removed all cancer cells many days after the procedure. However, rapid and accurate testing during surgery is needed to detect residual cancer to decrease cancer recurrence and the necessity for repeated surgery or treatments. Polarization-sensitive optical coherence tomography (PS-OCT) is a new imaging technology that uses near-infrared light waves to generate real-time, high-resolution images of the microscopic structure of tissues, specifically looking at the organization of the tissues. Investigators have performed initial evaluations using this optical coherence tomography for detection of residual cancer (including CHF grants 02758 and 02204-T), which has had very encouraging results. This study will focus on assessing whether PS-OCT could help us improve the accuracy to detect residual cancer in dogs following soft tissue sarcoma or mammary cancer removal. This project will open the door to veterinarians having the technology to allow accurate, real-time interpretation of surgical margins to minimize the necessity for additional surgeries or other treatments and to decrease tumor recurrence.

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