366: Molecular Control of COX-2 Expression and Regulation of Prostaglandin Transport in Canine Mammary Tumors

Grant Status: Closed

Grant Amount: $107,182
Dr. Monique Dore, DVM PhD, University of Montreal
January 1, 2005 - December 31, 2006
Sponsor(s): Florida Association of Mastiff Exhibitors, Mary and Peter Hayes, Poodle Club of America Foundation
Breed(s): -All Dogs
Research Program Area: Prevention

Abstract

Tumors originating from the mammary gland represent one of the most frequent forms of cancer in female dogs. However, very little information is known about the mechanisms involved in the development of this cancer. In dogs, the growth of mammary tumors can recur following surgical excision or cancerous cells can appear in distant organs. Cyclooxygenase-2 (COX-2), an enzyme that is essential in the production of prostaglandins, has been implicated in various forms of cancer in humans, including breast cancer. We have recently reported for the first time that COX-2 is induced in the majority of canine malignant mammary tumors. The objective of this proposal is to study the molecular mechanisms involved in the regulation of COX-2 gene expression in canine mammary tumors. We will also characterize the expression of a novel prostaglandin transporter in these tumors. It is expected that a better comprehension of the mechanisms involved in COX-2 expression and prostaglandin transport in canine mammary cancer will help design new strategies for cancer therapy and prevention in dogs.

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