02855-A: Repurposing Drugs to Modulate Myeloid-derived Suppressor Cells (MDSCs) in Canine Soft Tissue Sarcomas

Grant Status: Open

Grant Amount: $13,782
Sita Withers, BVSc, PhD; Louisiana State University
March 1, 2021 - February 28, 2022

Sponsor(s):

Breed(s): -All Dogs
Research Program Area: Oncology
Donate to Support this Research Program Area

Abstract

This proposal addresses the need for a deeper understanding of how canine soft tissue sarcomas (STS) inhibit the anti-tumor immune response. The overarching goal is to define the effects of a particularly immunosuppressive cell type, myeloid-derived suppressor cells (MDSCs), on the host immune response within canine STSs, and to explore the ability of readily-available drugs to alter this activity. Investigators will address this goal by pursuing two objectives: 1) to define the types of immune cells and their function within the tumor and peripheral blood of dogs with STS; 2) to determine the ability of repurposed drugs (sildenafil, all-trans retinoic acid, and ranolazine) to decrease the immunosuppressive forces provided of tumor-infiltrating MDSCs in canine STS.  Investigators hypothesize that MDSCs will concentrate within the canine STS tumor and will display greater immunosuppressive functions in the tumor compared to peripheral blood, and that repurposed drugs can be used to decrease the immunosuppressive activity of MDSCs. Findings will be directly translatable to future clinical trials for canine STS.

Publication(s)

None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Connect With Us:
Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617
(888)-682-9696

Tax ID# 13-3813813

   2020 GuideStar logo

© 2020 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software