00837-A: Prognostic Significance of Ezrin Expression in Canine High-Grade Soft Tissue Sarcoma

Grant Status: Closed

Grant Amount: $8,165
Dr. Kathryn Vickery, VMD, Colorado State University
September 1, 2006 - August 31, 2007
Breed(s): -All Dogs
Research Program Area: Treatment

Abstract

"Soft tissue sarcomas (STS) are a group of malignant cancers arising from the skin and structures below the skin (connective tissues, muscles, and other structures), in predominately large breed dogs. These tumors tend to infiltrate through surrounding structures and destroy the normal tissue architecture. Low and intermediate grade STS are unlikely to spread to other organs whereas 44 percent of the high grade STS may spread to organs such as the lungs and lymph nodes. It is currently impossible to predict which high grade STS will go on to spread and therefore which patients might benefit from treatment (such as chemotherapy) to attempt to delay or prevent spread. Ezrin is a protein found on cell surfaces that has been shown to promote the spread of cancer. Recent studies have demonstrated the correlation between ezrin expression and cancer spread in canine osteosarcoma (bone cancer) as well as in human STS. The purpose of this study is to evaluate the expression of ezrin and its usefulness as a prognostic marker in canine high grade STS. This information may provide a more accurate prediction of tumor behavior and help determine the need for post-surgical therapies to address potential spread."

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