02825-A: Effect(s) of Atopic Dermatitis-associated Cytokines on Staphylococcus pseudintermedius

Grant Status: Open

Grant Amount: $14,999
Domenico Santoro, DVM, MS, DrSc, PhD; University of Florida
August 1, 2020 - July 31, 2021

Sponsor(s):

Breed(s): -All Dogs
Research Program Area: Dermatology and Allergic Disease
Donate to Support this Research Program Area

Abstract

Allergies are extremely common in dogs, with environmental allergy being one of the most common. The exact cause of allergies is unknown but does present with an abnormal immune response. An immune response is a complex mechanism by which the body fights infections. A major component of this mechanism is made of small signaling proteins called cytokines. In healthy individuals, cytokines are important to maintain a balance between clearing infection and controlling inflammation. However, in allergic dogs, an abnormal immune response may be associated with tissue damage and microbial imbalance. Most of the times, treating the infection results in controlling the allergic flare, but that may not always be sufficient. Recurrent, resistant infections are very difficult to treat in dogs. The lack of response to treatments could be due to the direct effects of the body’s inflammatory response (cytokines) on bacterial growth (alone or in biofilm structures). This phenomenon is well known in human medicine but no studies have been published in veterinary medicine yet. The aim of this study is to understand the relationship between cytokines, associated with allergies and bacteria. If there is an association between immune response and increase in bacterial growth, these findings could open new therapeutic options for controlling bacterial infections in allergic dogs. Such results will pose the basis for new therapies to increase the quality of life of affected pets as well as decreasing the amount of bacterial resistance.

Publication(s)

None at this time.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Connect With Us:
Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617
(888)-682-9696

Tax ID# 13-3813813

   2020 GuideStar logo

© 2020 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software