02811: Prospective View Into the Use of Antimicrobials in Canine Pyometra and Prognostic Risk Factors for Postoperative Infection and Hospitalization

Grant Status: Open

Grant Amount: $47,342
Sari Mölsä, DVM, PhD; University of Helsinki
September 1, 2020 - August 31, 2024

Sponsor(s):

Breed(s): -All Dogs
Research Program Area: Reproductive Conditions
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Abstract

Increasing antimicrobial resistance is one of the biggest threats to human and animal welfare and refraining from the use of unnecessary antimicrobials is the only way to control this challenge. This study evaluates the use of antimicrobials in canine pyometra and risk factors for postoperative infection and hospitalization. Pyometra is a common disease of the reproductive tract. Ovariectomy or ovariohysterectomy are surgical procedures commonly used to prevent reproduction and uterine infectious diseases in female dogs. Medication is commonly prescribed postoperatively but there are no reliable data on its necessity. Emerging resistance in Escherichia coli-bacteria associated with pyometra is known to hamper the antimicrobial effect. Further, some dogs require prolonged hospitalization postoperatively, however, the predictive factors for hospitalization are unknown.

The aims of the study are to identify the dogs that benefit from antimicrobial treatment after surgery of uncomplicated pyometra, and to determine whether there is a difference in occurrences of postoperative surgical site infections (SSIs) or urinary tract infections (UTIs) in dogs that receive a course of antimicrobials postoperatively and those that do not. Further aims are to identify and characterize the bacterial strains; compare the antimicrobial resistance and virulence among bacterial isolates from the uterus and urine as well as the bacteria causing postoperative surgical site infection; and evaluate the utility of a recently validated scoring system in predicting the need for prolonged hospitalization in canine pyometra patients. Based on the findings, the use of antimicrobials may be minimized in patients that would not benefit from the medication and targeted to the patients that actually need it, improving suitability as well as cost in the treatment of canine pyometra.

Publication(s)

None at this time.

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