02653-A: Evaluation of the Serum and Cutaneous Levels of Chemokines in Atopic Dogs

Grant Status: Open

Grant Amount: $14,967
Domenico Santoro, DVM, MS, DrSc, PhD; University of Florida
February 1, 2019 - January 31, 2021

Sponsor(s): Bichon Frise Club of America, Inc., Westie Foundation of America, Inc.

Breed(s): -All Dogs
Research Program Area: Dermatology and Allergic Disease
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One Health: Yes


Atopic dermatitis (AD) is very common in dogs and children. AD is affected by complex and yet incompletely understood interactions between many factors such as environment, different types of white blood cells, and immunological factors. Chemokines are one of the factors that are used to modulate the immune system, leading to AD. Specific inflammatory chemokines were chosen for this study based on their relevance to AD from previously published studies in human and veterinary medicine. This study will evaluate the levels of these chemokines in blood, exosomes (a small pouch from cells that is used for communication between cells via blood), and skin of dogs with AD. In addition, the investigators will look for a correlation between the levels of these chemokines and severity of AD with a long-term goal to find a potential tool for monitoring and treating AD in dogs and humans.


Santoro, D., Archer, L., & Chong, E. (2022). Evaluation of cutaneous and circulating (serum and exosomes) levels of chemokines (CCL17, CCL22, CCL27 and CCL28) in atopic dogs and their correlation with severity of the disease. Veterinary Dermatology. https://doi.org/10.1111/vde.13061

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