02417-A: Serum total histones in dogs with acute pancreatitis, their association with laboratory findings, markers of inflammation and outcome: a prospective longitudinal study

Grant Status: Closed

Grant Amount: $14,200
Ran Nivy, DVM; The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem
December 1, 2017 - November 30, 2018

Sponsor(s):

Breed(s): Miniature Schnauzer
Research Program Area: Endocrinology
Donate to Support this Research Program Area

Abstract

Acute pancreatitis (AP) is a common, potentially fatal, inflammatory disease in dogs. Miniature Schnauzers and several Terrier and non-sporting breeds are predisposed to develop AP. The spectrum of clinical signs greatly varies, from transient inappetence in mild cases, to intractable gastro-intestinal signs and jaundice in severe ones. The result of aberrant activation of pancreatic digestive enzymes, the ensuing inflammatory reaction within the pancreas and its surrounding tissues induces edema formation and tissue necrosis. In severe cases, inflammation spreads to other organs, leading to hemostatic disturbances, multi-organ dysfunction and ultimately, to death. Several measurable inflammation markers increase in canine pancreatitis. Recently, studies of human and murine AP have demonstrated significant increases in extracellular serum histones. Histones are evolutionally conserved nuclear proteins, constituting the basic structure with which DNA interacts. Histones exert proinflammatory properties, with many deleterious effects on various body cells, and hemostasis. Interestingly, their pernicious effects can be partly or completely abrogated therapeutically (e.g., administering heparin or activated protein C). Recently, circulating histones have shown excellent performance in predicting persistent organ failure and mortality in humans with AP. The investigators will measure, free total serum histones in dogs with naturally occurring AP, and examine their association with other laboratory analytes, and with the prognosis. Should serum histones be found to increase in canine AP, as in humans, this may open up new therapeutic and research avenues for this serious disease.

Publication(s)

Nivy, R., Kuzi, S., Yochai, A., Aroch, I., & Bruchim, Y. (2021). Evaluation of serum histone concentrations and their associations with hemostasis, markers of inflammation, and outcome in dogs with naturally occurring acute pancreatitis. American Journal of Veterinary Research, 82(9), 701–711. https://doi.org/10.2460/ajvr.82.9.701

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617
(888)-682-9696

Tax ID# 13-3813813

  

© 2021 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.