03158: The Associations between Circulating Saturated and Unsaturated Fatty Acids and the Fecal Microbiome and Metabolome with the Development and Severity of Canine Acute Pancreatitis
Grant Status: Open
Abstract
Pancreatitis, inflammation of the pancreas, occurs when safety mechanisms responsible for preventing intra-pancreatic activation of digestive enzymes fail, allowing pancreatic auto-digestion. Acute pancreatitis (AP) is common in dogs, and may progress into a severe, fatal disease. Increased serum fatty acid (sFAs) concentrations (‘hyperlipidemia’) and obesity are risk factors for AP; however, additional factors determine AP occurrence and severity. Data in humans and mice with AP suggest that unsaturated FAs (UFAs) mediate pancreatic autodigestion, leading to tissue necrosis, consequent severe inflammatory reactions, potential systemic complications, and death. High UFAs consumption is associated with higher death rates in humans with AP. Additionally, humans and mice with AP sustain alterations in the intestinal microbiome and metabolome composition (“dysbiosis”), some of which may be induced by dietary UFAs, and may contribute to reduced intestinal function and systemic complications in AP. Yet, the serum FAs profile and related intestinal microbial alterations in dogs with AP are unknown.
Publication(s)
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.
