02290-MOU: Further Studies to Identify the Mutation Responsible for DUNGd

Grant Status: Closed

Grant Amount: $14,904
Dennis O'Brien; University of Missouri
July 1, 2016 - December 31, 2017

Sponsor(s): Gordon Setter Club of America

Breed(s): Gordon Setter
Research Program Area: Neurology
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Abstract

A hereditary disease that the breeders called DUNGd was recognized in Gordon Setters in the early 1990s and reported in the veterinary literature in 2000 (Journal of Veterinary Diagnostic Investigation 12:570–573). Affected pups develop normally until 3-4 weeks of age when they show progressive behavioral changes, gait abnormalities and weakness. By 5-6 weeks of age, they are recumbent and must be euthanized. The investigators will utilize the latest genomic techniques (next-generation whole genome sequencing and gene mapping) to identify genes associated with the disease. If a mutation that appears to cause the disease is found, they will develop a DNA test to identify carriers of the mutation, and thus permit breeders to avoid producing affected pups in the future.

Funding for the research is provided through the efforts and generosity of the Gordon Setter Club of America. The AKC Canine Health Foundation supports the funding of this effort and will oversee administration of funds and scientific progress.

Publication(s)

None at this time.

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