00709-A: A DNA Marker for Neonatal Encephalopathy in Standard Poodles

Grant Status: Closed

Grant Amount: $12,933.6
Dr. Dennis P. O'Brien, DVM PhD, University of Missouri, Columbia
January 1, 2006 - June 30, 2006
Breed(s): Standard Poodle
Research Program Area: Prevention

Abstract

We first recognized a progressive, fatal brain disease (neonatal encephalopathy) in a litter of Standard Poodle pups in 1997. Subsequently, we identified a total of 18 pups from throughout the US who died of the condition. With the help of the breeders and the Poodle Club of America, we collected DNA samples from the affected pups and family members and have mapped the gene responsible to a small segment of canine chromosome 36. We propose further narrowing the location of the gene to a reasonable number of potential candidates by developing additional microsatellite markers within the target region and identifying recombinations. We will then sequence the genes within this region, beginning with the genes that are most likely to affect nervous system function. When the disease causing mutation is found, we will develop an assay to detect the mutant gene and screen all the families that have had DNA submitted to identify carriers. We will then publish the mutation so that the test will become readily available for breeders and the gene can be eliminated from the breed.

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Make an Investment Today:

  • $50
  • $100
  • $250
  • $1000
  • Give Now
Connect With Us:
Get Canine Health News:
Please leave this field empty

© 2016 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software