01868-A: Development of a Novel System for Controlled Drug Delivery in the Dog

Grant Status: Closed

Grant Amount: $12,960
Lei Kerr, PhD; Miami University
August 1, 2012 - July 31, 2013


Breed(s): -All Dogs
Research Program Area: General Canine Health
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Titanium (Ti) implant is a widely used implant materials. There are numerous Ti implant surgeries performed in both human and animals each year. In this proposal, Dr. Kerr will develop an innovative drug carrier to control drug release for canine implant surgery applications (e.g. orthopedic and dental). The drugs under investigation in this proposal are gemcitabine, carpofen and lidocaine due to their importance in canine implant surgeries. This innovative drug carrier will be synthesized by developing a coating of biodegradable polymer filled TiO2 nanotubes on Ti implant surface. If this novel drug carrier is successful, it will have broad application for treatment of common canine diseases such as hip and elbow dysplasia, osteosarcoma and enhanced wound healing after surgery.


Jia, H., & Kerr, L. L. (2013). Sustained Ibuprofen Release Using Composite Poly(Lactic-co-Glycolic Acid)/Titanium Dioxide Nanotubes from Ti Implant Surface. Journal of Pharmaceutical Sciences, 102(7), 2341–2348. https://doi.org/10.1002/jps.23580
Jia, H., & Kerr, L. L. (2015). Kinetics of drug release from drug carrier of polymer/TiO 2 nanotubes composite-pH dependent study. Journal of Applied Polymer Science, 132(7), n/a-n/a. https://doi.org/10.1002/app.41570

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