00859-A: Canine Immune-Mediated Hemolytic Anemia

Grant Status: Closed

Grant Amount: $12,960
Lorna J. Kennedy, PhD; University of Manchester
January 1, 2007 - December 31, 2008

Sponsor(s): American Cavalier King Charles Spaniel Club Charitable Trust

Breed(s): -All Dogs
Research Program Area: Immunology and Infectious Disease
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Project Summary

We have previously identified a set of genes associated with Immune Mediated Haemolytic Anaemia (IMHA) in a region of the genome that is rich in immune genes. We have now performed a whole genome scan comparing 35 Cocker and Springer Spaniels having IMHA with 49 unaffected control dogs, which has revealed 91 SNPs that are significantly associated with IMHA, and are spread over 33 different canine chromosomes. Eight of these SNP associations are highly significant and give us great hope that we will be able to identify other genes/loci associated with this disease. If we can identify such genes, it may be possible to start selective breeding to reduce the risk of Cocker and Springer Spaniels developing IMHA.


Ke, X., Kennedy, L. J., Short, A. D., Seppälä, E. H., Barnes, A., Clements, D. N., … Ollier, W. E. R. (2011). Assessment of the functionality of genome-wide canine SNP arrays and implications for canine disease association studies. Animal Genetics, 42(2), 181–190. https://doi.org/10.1111/j.1365-2052.2010.02132.x

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