772: Autoimmune Disease Susceptibility in Dogs: Evaluation of Fcy-receptor Candidate Genes for (Auto-) Immune Mediated Anemia and Thrombocytopenia

Grant Status: Closed

Grant Amount: $35,000
Dr. Ina Pfeiffer,, University of Kassel
April 1, 2007 - March 31, 2008
Sponsor(s): Akita Club of America, Inc., American Bullmastiff Association, Flat-Coated Retriever Foundation, Golden Retriever Foundation, Great Dane Club of America, Great Dane Club of America Charitable Trust, Hoffman Miniature Schnauzer Donor Advised Fund, Orthopedic Foundation for Animals, Rottweiler Health Foundation, Samoyed Club of America Education & Research Foundation, Starlight Fund
Breed(s): Cocker Spaniel, Irish Setter
Research Program Area: Prevention

Abstract

This research will open a new perspective in canine autoimmune diseases if, similar to humans, a genetic correlation between affected animals and certain FcR-alleles are identified. With the established Fc-receptor primer set, screening of other autoimmune disease with a genetic background will be possible. If our experimental approach is successful, Cocker Spaniel and Irish Red Setter breeders will have a genetic test to identify dogs with a predisposition for immune-mediated diseases. Furthermore, for other dog breeds, a genetic testing might be possible because of a high identity of relevant genes.

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