00339-A: Expression of Vascular Endothelial Growth Factor (VEGF) and Basic Fibroblast Growth Factor (bFGF) in Canine Oral Malignant Melanoma

Grant Status: Closed

Grant Amount: $8,288.03
Kathryn Taylor, DVM; Auburn University
October 1, 2004 - September 30, 2005


Breed(s): Cocker Spaniel, English Cocker Spaniel, Miniature Poodle, Chow Chow, Standard Poodle, Dachshund, Scottish Terrier
Research Program Area: Oncology
Donate to Support this Research Program Area


The purpose of this investigation is to determine the level of Vascular Endothelial Growth Factor (VEGF) and basic Fibroblast Growth Factor (bFGF) expression in dogs with oral malignant melanoma. Serum and plasma levels of these growth factors will be determined for 20 dogs with oral melanoma and 20 control dogs using validated ELISA testing. Immunohistochemistry will be performed on 20 canine oral malignant melanomas to determine tumor expression of VEGF and bFGF. Statistical analysis will be performed to establish the association between the clinical stage of melanoma in each patient and the level of growth factor expression. These data may be correlated to survival time to determine if growth factor expression is a measurable prognostic factor and a potential target for future treatment.


Taylor, K. H., Smith, A. N., Higginbotham, M., Schwartz, D. D., Carpenter, D. M., & Whitley, E. M. (2007). Expression of vascular endothelial growth factor in canine oral malignant melanoma. Veterinary and Comparative Oncology, 5(4), 208–218. https://doi.org/10.1111/j.1476-5829.2007.00130.x

Help Future Generations of Dogs

Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.

Learn How to Help

Connect With Us:
Get Canine Health News:
Please leave this field empty
American Kennel Club Canine Health Foundation, Inc

8051 Arco Corporate Dr.
Suite 300
Raleigh, NC 27617

Tax ID# 13-3813813

   2020 GuideStar logo

© 2020 AKC Canine Health Foundation | Privacy Policy | Site Map

Site by Blackbaud, Inc.

Powered by Blackbaud
nonprofit software