0001626T: Significance of Tumor Suppressor Genes in Canine Cancer
Grant Status: Closed
Project SummaryThe research conducted in this study will provide the basis for future research that may, ultimately, lead to scientists being able to provide a better assessment of individuals� risks for cancer (or for cancer in progeny), as well as determine whether a given dog is a good candidate for a given therapy. This project has helped to broaden the understanding of why tumors happen, so that the abnormalities can be targeted and better therapies devised. Researchers developed and tested gene therapy for melanoma. In a clinical trial involving five dogs with facial or oral melanoma, they found that the gene therapy, in which tumors were injected with modified genes, was both free of adverse effects and effective.
Publication(s)- Koenig A BS, Fosmire S, Wojcieszyn J, Modiano JF. Expression and significance of p53, rb, p21/waf-1, p16/ink-4a, and PTEN tumor suppressors in canine melanoma. Vet Pathol 2002;39:458-472. - Bianco SR, Sun J, Fosmire SP, et al. Enhancing antimelanoma
Help Future Generations of Dogs
Participate in canine health research by providing samples or by enrolling in a clinical trial. Samples are needed from healthy dogs and dogs affected by specific diseases.