0001626T: Significance of Tumor Suppressor Genes in Canine Cancer

Grant Status: Closed

Grant Amount: $93,570.63
Jaime F Modiano, VMD, PhD; University of Colorado
November 12, 1999 - August 31, 2000

Sponsor(s): American Boxer Charitable Foundation, Golden Retriever Foundation, Great Dane Club of America, Medallion Rottweiler Club, Rottweiler Health Foundation, Scottish Terrier Club of America

Breed(s): Rottweiler, Boxer, Golden Retriever
Research Program Area: Oncology
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Project Summary

The research conducted in this study will provide the basis for future research that may, ultimately, lead to scientists being able to provide a better assessment of individuals' risks for cancer (or for cancer in progeny), as well as determine whether a given dog is a good candidate for a given therapy. This project has helped to broaden the understanding of why tumors happen, so that the abnormalities can be targeted and better therapies devised. Researchers developed and tested gene therapy for melanoma. In a clinical trial involving five dogs with facial or oral melanoma, they found that the gene therapy, in which tumors were injected with modified genes, was both free of adverse effects and effective.

Publication(s)

Bianco, S. R., Sun, J., Fosmire, S. P., Hance, K., Padilla, M. L., Ritt, M. G., … Modiano, J. F. (2003). Enhancing antimelanoma immune responses through apoptosis. Cancer Gene Therapy, 10(9), 726–736. https://doi.org/10.1038/sj.cgt.7700625
 
Koenig, A., Bianco, S. R., Fosmire, S., Wojcieszyn, J., & Modiano, J. F. (2002). Expression and Significance of p53, Rb, p21/waf-1, p16/ink-4a, and PTEN Tumor Suppressors in Canine Melanoma. Veterinary Pathology, 39(4), 458–472. https://doi.org/10.1354/vp.39-4-458
 
Koenig, A., Wojcieszyn, J., Weeks, B. R., & Modiano, J. F. (2001). Expression of S100a, Vimentin, NSE, and Melan A/MART-1 in Seven Canine Melanoma Cell Lines and Twenty-nine Retrospective Cases of Canine Melanoma. Veterinary Pathology, 38(4), 427–435. https://doi.org/10.1354/vp.38-4-427

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