01346-A: Genetic Basis of Sebaceous Adenitis in Dogs
Grant Status: Closed
Project SummarySebaceous adenitis (SA) is an inflammatory skin disease of unknown cause. There seems to be a genetic predisposition in SA; however, the exact mode of inheritance remains unknown. The clustering of SA in Havanese dogs indicates that there is very likely a significant genetic component and possibly a related gene of major effect. The purpose of this study was to enroll 25 SA affected and 25 non-affected Havanese dogs in order to develop a DNA bank and hopefully determine the mode of inheritance of SA in this breed. Definitive diagnosis was based on biopsy confirmation of SA. We enrolled a total of 92 purebred Havanese dogs. Forty dogs were diagnosed with SA and 52 dogs were not SA affected and were enrolled as control dogs. These dogs were enrolled from different parts of the United States. There were 59 female dogs and 33 male dogs. The SA affected dogs included 27 female and 13 male dogs. The non-affected dogs included 32 female and 20 male dogs. The age of the SA affected dogs at the time of inclusion in the study ranged from 2.5-15 years-old (average: 6.8). The age of onset of SA was known in 30 of the 40 dogs and ranged from 0.5-6 years-old (average: 2.4). One of the 40 dogs was asymptomatic for SA but had SA confirmed via biopsy (subclinically affected). The age of the non-affected dogs at the time of inclusion in the study ranged from 6.4-15.3 years-old (average: 8.4). Blood samples were collected from all 92 dogs and a DNA bank was generated. Pedigree analysis revealed that the inheritance of SA is most consistent with autosomal recessive inheritance with partial penetrance or polygenic recessive inheritance. The ultimate goal of this study is to provide preliminary data for future studies for identification of the genes causing susceptibility to SA in Havanese dogs and potentially for production of a DNA-based marker test to assist breeders in reducing the incidence of SA. We hope to receive future financial support for analysis of the available DNA bank.
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